GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292838/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292838GEOGSEfalseDlx1&2 Directly Promote Expression of Cxcl14 to Control Synapse Development and Interneuron Survival [scRNA-seq]Dlx genes have fundamental roles in the generation, differentiation and functions of virtually all forebrain GABAergic neurons. Here we focused on defining the key genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature cortical GABAergic interneurons (CINs), and by identifying DLX-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs and for CIN survival.2026/05/01GSE292838GSM8866301GSM8866300GSM8866299GSM8866298GSM8866297GSM886629624247292838Mus musculus