{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293063/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293063"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Whole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole","description":"We previously reported that mebendazole is an effective anti-AML therapeutic and acts via induction of MYB degradation. The present experiemnt was performed in order to uncover pathways of potential resistance in AML cells to mebendazole exposure. A whole genome CRISPR drop-out screen was performed on THP-1 AML cells exposed to 1 micromolar mebendazole or DMSO in order to identify genes that decreased AML sensitivity to this drug.","dates":{"publication":"2026/04/01"},"accession":"GSE293063","cross_references":{"GSM":["GSM8875055","GSM8875054"],"GPL":["18573"],"GSE":["293063"],"taxon":["Homo sapiens"]}}