{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293352/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293352"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis","description":"SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker for redox-based and ferroptosis-combined therapies in HCC.","dates":{"publication":"2026/09/30"},"accession":"GSE293352","cross_references":{"GSM":["GSM8880706","GSM8880707"],"GPL":["35718"],"GSE":["293352"],"taxon":["Homo"]}}