GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293352/primary200OKOtherHomoOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293352GEOGSEfalseSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 AxisSENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker for redox-based and ferroptosis-combined therapies in HCC.2026/09/30GSE293352GSM8880706GSM888070735718293352Homo