{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293566/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293566"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis [RNA-Seq]","description":"SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker for redox-based and ferroptosis-combined therapies in HCC.","dates":{"publication":"2026/09/30"},"accession":"GSE293566","cross_references":{"GSM":["GSM8885619","GSM8885620","GSM8885618","GSM8885617","GSM8885616","GSM8885615"],"GPL":["24676"],"GSE":["293566"],"taxon":["Homo sapiens"]}}