GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293566/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293566GEOGSEfalseSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis [RNA-Seq]SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker for redox-based and ferroptosis-combined therapies in HCC.2026/09/30GSE293566GSM8885619GSM8885620GSM8885618GSM8885617GSM8885616GSM888561524676293566Homo sapiens