{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293592/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Mus musculus"],"gds_type":["Methylation profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293592"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Maternal immune activation delays DNA methylation and physiological maturation of cortical excitatory neurons","description":"Elevated levels of maternal pro-inflammatory cytokines during gestation can disrupt offspring neural development, increasing the risk of neurodevelopmental disorders. We studied the effects of Poly(I:C)-induced maternal immune activation (PIC-MIA) during mid-gestation on the DNA methylation and transcriptome of developing cortical excitatory neurons. PIC-MIA disrupted the developmental regulation of synapse-related genes and of genes implicated in autism spectrum disorders. Genomic regions that gain or lose DNA methylation during normal development were altered following PIC-MIA, including neurodevelopmental transcription factor binding sites. The DNA methylation and transcriptional changes were consistent with a delay in excitatory neuron maturation. Whole-cell recordings showed that PIC-MIA preferentially altered the physiological development of layer 5 excitatory neurons. Taken together, present results suggest that alterations in the epigenome, through the disruption of circuit formation, may drive the long-term consequences of maternal infection during gestation.","dates":{"publication":"2026/07/27"},"accession":"GSE293592","cross_references":{"GSM":["GSM8886361","GSM8886360","GSM8886365","GSM8886364","GSM8886363","GSM8886362","GSM8886369","GSM8886402","GSM8886401","GSM8886368","GSM8886400","GSM8886367","GSM8886366","GSM8886406","GSM8886405","GSM8886404","GSM8886403","GSM8886409","GSM8886408","GSM8886407","GSM8886350","GSM8886354","GSM8886353","GSM8886352","GSM8886351","GSM8886358","GSM8886357","GSM8886356","GSM8886355","GSM8886359","GSM8886343","GSM8886342","GSM8886341","GSM8886340","GSM8886347","GSM8886346","GSM8886345","GSM8886344","GSM8886349","GSM8886348","GSM8886332","GSM8886331","GSM8886330","GSM8886336","GSM8886335","GSM8886334","GSM8886333","GSM8886339","GSM8886338","GSM8886337","GSM8886321","GSM8886320","GSM8886325","GSM8886324","GSM8886323","GSM8886322","GSM10024486","GSM8886329","GSM8886328","GSM8886327","GSM8886326","GSM8886390","GSM8886394","GSM8886393","GSM8886392","GSM8886391","GSM8886398","GSM8886397","GSM8886396","GSM8886395","GSM8886314","GSM8886399","GSM8886318","GSM8886317","GSM8886316","GSM8886315","GSM8886319","GSM8886383","GSM8886382","GSM8886381","GSM8886380","GSM8886387","GSM8886386","GSM8886385","GSM8886384","GSM8886389","GSM8886388","GSM10024485","GSM8886372","GSM8886371","GSM8886370","GSM8886376","GSM8886375","GSM8886374","GSM8886373","GSM8886413","GSM8886412","GSM8886379","GSM8886378","GSM8886411","GSM8886377","GSM8886410","GSM8886417","GSM8886416","GSM8886415","GSM8886414","GSM8886419","GSM8886418"],"GPL":["21103","17021","19057","24247"],"GSE":["293592"],"taxon":["Mus musculus"],"PMID":["[42686997]","[42255505]"]}}