{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293614/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293614"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis in the prefrontal cortex of Dyrk1a+/I48X heterozygous mice treated with drug","description":"Autism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.","dates":{"publication":"2026/07/28"},"accession":"GSE293614","cross_references":{"GSM":["GSM8886919","GSM8886918","GSM8886917","GSM8886923","GSM8886922","GSM8886889","GSM8886888","GSM8886921","GSM8886920","GSM8886887","GSM8886927","GSM8886926","GSM8886925","GSM8886924","GSM8886909","GSM8886908","GSM8886907","GSM8886906","GSM8886912","GSM8886911","GSM8886910","GSM8886916","GSM8886915","GSM8886914","GSM8886913","GSM8886939","GSM8886941","GSM8886940","GSM8886945","GSM8886901","GSM8886944","GSM8886900","GSM8886943","GSM8886942","GSM8886905","GSM8886904","GSM8886903","GSM8886902","GSM8886929","GSM8886928","GSM8886893","GSM8886892","GSM8886891","GSM8886890","GSM8886897","GSM8886930","GSM8886896","GSM8886895","GSM8886894","GSM8886934","GSM8886933","GSM8886899","GSM8886932","GSM8886931","GSM8886898","GSM8886938","GSM8886937","GSM8886936","GSM8886935"],"GPL":["24247"],"GSE":["293614"],"taxon":["Mus musculus"]}}