GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293627/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293627GEOGSEfalseTranscriptome analysis in the prefrontal cortex of Shank3 delta C heterozygous mice treated with drugAutism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.2026/07/28GSE293627GSM8887293GSM8887294GSM8887295GSM8887296GSM8887290GSM8887291GSM8887292GSM8887297GSM8887298GSM8887299GSM8887282GSM8887283GSM8887284GSM8887285GSM8887280GSM8887281GSM8887323GSM8887324GSM8887286GSM8887287GSM8887320GSM8887321GSM8887288GSM8887322GSM8887289GSM8887271GSM8887272GSM8887273GSM8887274GSM8887270GSM8887279GSM8887312GSM8887313GSM8887314GSM8887315GSM8887275GSM8887276GSM8887310GSM8887277GSM8887278GSM8887311GSM8887316GSM8887317GSM8887318GSM8887319GSM8887301GSM8887268GSM8887302GSM8887269GSM8887303GSM8887304GSM8887300GSM8887309GSM8887305GSM8887306GSM8887307GSM888730824247293627Mus musculus