{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293706/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293706"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis in the prefrontal cortex of Shank3 KI heterozygous mice treated with drug","description":"Autism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.","dates":{"publication":"2026/07/28"},"accession":"GSE293706","cross_references":{"GSM":["GSM8888940","GSM8888941","GSM8888942","GSM8888943","GSM8888948","GSM8888904","GSM8888905","GSM8888949","GSM8888906","GSM8888907","GSM8888944","GSM8888945","GSM8888946","GSM8888947","GSM8888930","GSM8888931","GSM8888932","GSM8888937","GSM8888938","GSM8888939","GSM8888933","GSM8888934","GSM8888935","GSM8888936","GSM8888919","GSM8888962","GSM8888920","GSM8888921","GSM8888960","GSM8888961","GSM8888926","GSM8888927","GSM8888928","GSM8888929","GSM8888922","GSM8888923","GSM8888924","GSM8888925","GSM8888908","GSM8888909","GSM8888951","GSM8888952","GSM8888953","GSM8888954","GSM8888910","GSM8888950","GSM8888959","GSM8888915","GSM8888916","GSM8888917","GSM8888918","GSM8888911","GSM8888955","GSM8888956","GSM8888912","GSM8888957","GSM8888913","GSM8888914","GSM8888958"],"GPL":["24247"],"GSE":["293706"],"taxon":["Mus musculus"]}}