GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293706/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293706GEOGSEfalseTranscriptome analysis in the prefrontal cortex of Shank3 KI heterozygous mice treated with drugAutism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.2026/07/28GSE293706GSM8888940GSM8888941GSM8888942GSM8888943GSM8888948GSM8888904GSM8888905GSM8888949GSM8888906GSM8888907GSM8888944GSM8888945GSM8888946GSM8888947GSM8888930GSM8888931GSM8888932GSM8888937GSM8888938GSM8888939GSM8888933GSM8888934GSM8888935GSM8888936GSM8888919GSM8888962GSM8888920GSM8888921GSM8888960GSM8888961GSM8888926GSM8888927GSM8888928GSM8888929GSM8888922GSM8888923GSM8888924GSM8888925GSM8888908GSM8888909GSM8888951GSM8888952GSM8888953GSM8888954GSM8888910GSM8888950GSM8888959GSM8888915GSM8888916GSM8888917GSM8888918GSM8888911GSM8888955GSM8888956GSM8888912GSM8888957GSM8888913GSM8888914GSM888895824247293706Mus musculus