GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293976/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293976GEOGSEfalseHiston lactylation drives HAS2 expression in gastric cancer tumorigensis after H.pylori infectionHistone lactylation, an epigenetic modification, promotes tumor growth and immune evasion in various cancers. Our study found increased pan-lysine lactylation and H3K18la in gastric tissues, linked to poor prognosis. Inhibiting glycolysis and silencing lactate dehydrogenase reduced H3K18la, boosting CD8+ T-cell activity against gastric cancer. H3K18la activated HAS2 transcription, enhancing MYC nuclear transport and PD-L1 expression..Our data provide a molecular framework for Histone lactylation in the process of gastric cancer.2026/04/09GSE293976GSM8895680GSM8895682GSM8895671GSM8895681GSM8895673GSM8895672GSM8895675GSM8895674GSM8895677GSM8895676GSM8895679GSM889567816791293976Homo sapiens