{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294083/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294083"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single cell transcriptomic analysis of splenic gamma delta T cells, thymic gamma delta T cells and thymic DN1-DN2-DN3 cells from WT and GFI1 KO mice.","description":"GFI1 is a transcription factor known to be essential for hematopoiesis and lymphoid cell generation. We have recently found that gamma delta T cells express GFI1 and its absence can impact gamma delta T cell formation. In order to identify how the lack of GFI1 can affect the development of thegamma delta T cell subsets, we have performed a single cell sequencing approach using 10X genomics scRNAseq on splenic gamma delta T cells, thymic gamma delta T cells and a pool of thymic DN1-2-3 (DN) cells from WT and GFI1 KO mice. The sc RNA-seq highlighted differential transcriptomic changes between WT and GFI1 KO cells showing enrichment or absence of specific subsets of gamma delta cells and their thymic progenitors.","dates":{"publication":"2026/07/23"},"accession":"GSE294083","cross_references":{"GSM":["GSM8898376","GSM8898377","GSM8898385","GSM8898386","GSM8898375","GSM8898378","GSM8898379","GSM8898380","GSM8898383","GSM8898384","GSM8898381","GSM8898382"],"GPL":["24247"],"GSE":["294083"],"taxon":["Mus musculus"],"PMID":["[42620748]"]}}