GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294123/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294123GEOGSEfalseTranscriptome analysis in the prefrontal cortex of Shank2 heterozygous mice treated with drugAutism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.2026/07/28GSE294123GSM8898981GSM8898982GSM8898980GSM8898985GSM8898986GSM8898983GSM8898984GSM8898989GSM8898987GSM8898988GSM8899030GSM8899026GSM8899025GSM8899024GSM8899023GSM8898974GSM8899029GSM8898975GSM8899028GSM8899027GSM8898978GSM8898979GSM8898976GSM8898977GSM8899022GSM8899021GSM8899020GSM8899015GSM8899014GSM8899013GSM8899012GSM8899019GSM8899018GSM8899017GSM8899016GSM8899011GSM8899010GSM8898992GSM8899004GSM8899003GSM8898993GSM8898990GSM8899002GSM8898991GSM8899001GSM8899008GSM8898996GSM8898997GSM8899007GSM8898994GSM8899006GSM8899005GSM8898995GSM8898998GSM8899009GSM8898999GSM889900024247294123Mus musculus