GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294140/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294140GEOGSEfalsePFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [RNA-Seq]While there is significant progress in characterizing the pathogenesis of Parkinson's disease (PD), underlying cell biological events are less well-defined. Increasing evidence suggests that endolysosomal dysfunction is a critical driver of PD pathogenesis. In this study, we explored the impact of preformed α-synuclein fibrils (PFF) on endolysosomal function and on transcriptional reprogramming.2026/05/13GSE294140GSM8899375GSM8899369GSM8899368GSM8899370GSM8899374GSM8899373GSM8899372GSM889937124247294140Mus musculus[42120407]