{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294300/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294300"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell gene expression profiles of cells from primary colorectal cancer and adjacent normal tissue [scRNA-Seq]","description":"Colorectal cancer (CRC) is the third malignancy worldwide. RAS mutant CRC has a worse prognosis and resistant to immune therapies. Current research on the tumor microenvironment of RAS-mutant CRC remains limited, with few studies systematically characterizing its cellular composition or functional dynamics. A total of 36 clinical surgical samples (tumors and paired adjacent normal tissues) from 18 patients with primary CRC were collected for single-cell transcriptome sequencing.At the same time, each patient underwent genome sequencing, and 18 patients were divided into RAS gene mutation group (n=10) and wild-type group (n=8). Therefore, revealing the functional cell types and mechanism of immune evasion in RAS mutant CRC by scRNA-seq may contribute to discover new therapeutic targets.","dates":{"publication":"2026/07/22"},"accession":"GSE294300","cross_references":{"GSM":["GSM8901921","GSM8901943","GSM8901942","GSM8901920","GSM8901945","GSM8901923","GSM8901944","GSM8901922","GSM8901941","GSM8901940","GSM8901929","GSM8901928","GSM8901947","GSM8901925","GSM8901924","GSM8901946","GSM8901927","GSM8901949","GSM8901948","GSM8901926","GSM8901932","GSM8901954","GSM8901953","GSM8901931","GSM8901934","GSM8901955","GSM8901933","GSM8901950","GSM8901930","GSM8901952","GSM8901951","GSM8901939","GSM8901936","GSM8901935","GSM8901938","GSM8901937"],"GPL":["18573"],"GSE":["294300"],"taxon":["Homo sapiens"],"PMID":["[42143353]"]}}