{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294402"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part1]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294402","cross_references":{"GSM":["GSM8904392","GSM8904150","GSM8904151","GSM8904393","GSM8904390","GSM8904391","GSM8904158","GSM8904159","GSM8904156","GSM8904398","GSM8904157","GSM8904399","GSM8904154","GSM8904396","GSM8904397","GSM8904155","GSM8904394","GSM8904152","GSM8904395","GSM8904153","GSM8904381","GSM8904140","GSM8904382","GSM8904380","GSM8904389","GSM8904147","GSM8904148","GSM8904145","GSM8904387","GSM8904388","GSM8904146","GSM8904385","GSM8904143","GSM8904386","GSM8904144","GSM8904383","GSM8904141","GSM8904142","GSM8904384","GSM8904149","GSM8904172","GSM8904173","GSM8904170","GSM8904171","GSM8904178","GSM8904179","GSM8904176","GSM8904177","GSM8904174","GSM8904175","GSM8904161","GSM8904162","GSM8904160","GSM8904169","GSM8904167","GSM8904168","GSM8904165","GSM8904166","GSM8904163","GSM8904164","GSM8904590","GSM8904591","GSM8904114","GSM8904598","GSM8904356","GSM8904357","GSM8904115","GSM8904599","GSM8904354","GSM8904596","GSM8904112","GSM8904597","GSM8904355","GSM8904113","GSM8904594","GSM8904352","GSM8904110","GSM8904595","GSM8904111","GSM8904353","GSM8904592","GSM8904350","GSM8904351","GSM8904593","GSM8904118","GSM8904119","GSM8904116","GSM8904358","GSM8904117","GSM8904359","GSM8904580","GSM8904345","GSM8904103","GSM8904587","GSM8904346","GSM8904104","GSM8904588","GSM8904343","GSM8904585","GSM8904101","GSM8904586","GSM8904102","GSM8904344","GSM8904583","GSM8904341","GSM8904100","GSM8904584","GSM8904342","GSM8904581","GSM8904340","GSM8904582","GSM8904109","GSM8904349","GSM8904107","GSM8904108","GSM8904105","GSM8904589","GSM8904347","GSM8904348","GSM8904106","GSM8904370","GSM8904371","GSM8904136","GSM8904378","GSM8904137","GSM8904379","GSM8904134","GSM8904376","GSM8904377","GSM8904135","GSM8904374","GSM8904132","GSM8904375","GSM8904133","GSM8904372","GSM8904130","GSM8904131","GSM8904373","GSM8904138","GSM8904139","GSM8904360","GSM8904125","GSM8904367","GSM8904368","GSM8904126","GSM8904365","GSM8904123","GSM8904366","GSM8904124","GSM8904363","GSM8904121","GSM8904122","GSM8904364","GSM8904361","GSM8904120","GSM8904362","GSM8904129","GSM8904369","GSM8904127","GSM8904128","GSM8904554","GSM8904312","GSM8904796","GSM8904555","GSM8904313","GSM8904797","GSM8904552","GSM8904310","GSM8904794","GSM8904311","GSM8904795","GSM8904553","GSM8904792","GSM8904550","GSM8904793","GSM8904551","GSM8904790","GSM8904791","GSM8904318","GSM8904319","GSM8904558","GSM8904316","GSM8904317","GSM8904559","GSM8904314","GSM8904798","GSM8904556","GSM8904557","GSM8904315","GSM8904799","GSM8904543","GSM8904301","GSM8904785","GSM8904302","GSM8904786","GSM8904544","GSM8904783","GSM8904541","GSM8904300","GSM8904784","GSM8904542","GSM8904781","GSM8904540","GSM8904782","GSM8904780","GSM8904309","GSM8904549","GSM8904307","GSM8904308","GSM8904305","GSM8904789","GSM8904547","GSM8904306","GSM8904548","GSM8904303","GSM8904787","GSM8904545","GSM8904546","GSM8904304","GSM8904788","GSM8904334","GSM8904576","GSM8904577","GSM8904335","GSM8904574","GSM8904332","GSM8904575","GSM8904333","GSM8904572","GSM8904330","GSM8904331","GSM8904573","GSM8904570","GSM8904571","GSM8904338","GSM8904339","GSM8904578","GSM8904336","GSM8904337","GSM8904579","GSM8904323","GSM8904565","GSM8904566","GSM8904324","GSM8904563","GSM8904321","GSM8904564","GSM8904322","GSM8904561","GSM8904320","GSM8904562","GSM8904560","GSM8904329","GSM8904569","GSM8904327","GSM8904328","GSM8904325","GSM8904567","GSM8904326","GSM8904568","GSM8904752","GSM8904510","GSM8904511","GSM8904753","GSM8904750","GSM8904751","GSM8904518","GSM8904519","GSM8904758","GSM8904516","GSM8904517","GSM8904759","GSM8904514","GSM8904756","GSM8904515","GSM8904757","GSM8904512","GSM8904754","GSM8904755","GSM8904513","GSM8904741","GSM8904500","GSM8904742","GSM8904740","GSM8904749","GSM8904507","GSM8904508","GSM8904747","GSM8904505","GSM8904506","GSM8904748","GSM8904503","GSM8904745","GSM8904746","GSM8904504","GSM8904743","GSM8904501","GSM8904744","GSM8904502","GSM8904509","GSM8904532","GSM8904774","GSM8904775","GSM8904533","GSM8904772","GSM8904530","GSM8904531","GSM8904773","GSM8904770","GSM8904771","GSM8904538","GSM8904539","GSM8904778","GSM8904536","GSM8904537","GSM8904779","GSM8904534","GSM8904776","GSM8904535","GSM8904777","GSM8904763","GSM8904521","GSM8904764","GSM8904522","GSM8904761","GSM8904520","GSM8904762","GSM8904760","GSM8904529","GSM8904769","GSM8904527","GSM8904528","GSM8904767","GSM8904525","GSM8904526","GSM8904768","GSM8904523","GSM8904765","GSM8904766","GSM8904524","GSM8904716","GSM8904717","GSM8904714","GSM8904715","GSM8904712","GSM8904713","GSM8904710","GSM8904711","GSM8904718","GSM8904719","GSM8904705","GSM8904706","GSM8904703","GSM8904704","GSM8904701","GSM8904702","GSM8904700","GSM8904709","GSM8904707","GSM8904708","GSM8904730","GSM8904731","GSM8904738","GSM8904739","GSM8904736","GSM8904737","GSM8904734","GSM8904735","GSM8904732","GSM8904733","GSM8904720","GSM8904727","GSM8904728","GSM8904725","GSM8904726","GSM8904723","GSM8904724",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