{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294441/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294441"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Nanostring-Based Gene Expression Profiling of Melanoma Lymph Node Metastases","description":"This study investigates gene expression profiles in metastatic melanoma lymph node samples using the Nanostring nCounter platform. Samples were obtained from patients who were treatment-naïve, resistant, or responsive to immune checkpoint inhibitor (ICI) therapy. We applied both the PanCancer Immune Profiling Panel and a custom tissue-resident memory (TRM) T cell panel to assess immune cell composition and activation states. The dataset reveals transcriptional signatures associated with ICI response, including enrichment of TRM-associated genes and interferon-stimulated pathways in responders, and immunosuppressive features in resistant tumors. These data provide insights into the role of tumour-resident T cells and the tumour immune microenvironment in shaping response to immunotherapy.","dates":{"publication":"2026/06/08"},"accession":"GSE294441","cross_references":{"GSM":["GSM8905372","GSM8905361","GSM8905371","GSM8905360","GSM8905370","GSM8905369","GSM8905358","GSM8905357","GSM8905379","GSM8905368","GSM8905378","GSM8905367","GSM8905356","GSM8905377","GSM8905366","GSM8905365","GSM8905376","GSM8905364","GSM8905375","GSM8905374","GSM8905363","GSM8905373","GSM8905362","GSM8905359"],"GPL":["35751"],"GSE":["294441"],"taxon":["Homo sapiens"]}}