{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294446"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part2]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294446","cross_references":{"GSM":["GSM8905482","GSM8905481","GSM8905480","GSM8906337","GSM8906336","GSM8905489","GSM8906335","GSM8905488","GSM8906334","GSM8905487","GSM8906333","GSM8905486","GSM8906332","GSM8905485","GSM8906331","GSM8905484","GSM8905483","GSM8906330","GSM8906339","GSM8906338","GSM8905471","GSM8905470","GSM8906326","GSM8905479","GSM8906325","GSM8905478","GSM8906324","GSM8905477","GSM8905476","GSM8906323","GSM8906322","GSM8905475","GSM8906321","GSM8905474","GSM8906320","GSM8905473","GSM8905472","GSM8906329","GSM8906328","GSM8906327","GSM8906351","GSM8906350","GSM8906359","GSM8906117","GSM8906116","GSM8906358","GSM8906357","GSM8906115","GSM8906356","GSM8906114","GSM8906113","GSM8906355","GSM8906354","GSM8906112","GSM8906111","GSM8906353","GSM8906110","GSM8906352","GSM8906119","GSM8906118","GSM8906340","GSM8905493","GSM8905492","GSM8905491","GSM8905490","GSM8906348","GSM8906106","GSM8906105","GSM8906347","GSM8906104","GSM8906346","GSM8905499","GSM8906345","GSM8905498","GSM8906103","GSM8906102","GSM8906344","GSM8905497","GSM8906343","GSM8905496","GSM8906101","GSM8906342","GSM8905495","GSM8906100","GSM8906341","GSM8905494","GSM8906109","GSM8906108","GSM8906107","GSM8906349","GSM8905680","GSM8905446","GSM8905688","GSM8905687","GSM8905445","GSM8905444","GSM8905686","GSM8905443","GSM8905685","GSM8905684","GSM8905442","GSM8905441","GSM8905683","GSM8905440","GSM8905682","GSM8905681","GSM8905449","GSM8905448","GSM8905689","GSM8905447","GSM8905435","GSM8905677","GSM8905676","GSM8905434","GSM8905675","GSM8905433","GSM8905432","GSM8905674","GSM8905673","GSM8905431","GSM8905672","GSM8905430","GSM8905671","GSM8905670","GSM8905439","GSM8905438","GSM8905679","GSM8905437","GSM8905678","GSM8905436","GSM8905460","GSM8906315","GSM8905468","GSM8906314","GSM8905467","GSM8905466","GSM8906313","GSM8906312","GSM8905465","GSM8906311","GSM8905464","GSM8905463","GSM8906310","GSM8905462","GSM8905461","GSM8906319","GSM8906318","GSM8906317","GSM8906316","GSM8905469","GSM8905691","GSM8905690","GSM8905699","GSM8905457","GSM8906304","GSM8905698","GSM8906303","GSM8905456","GSM8906302","GSM8905455","GSM8905697","GSM8905696","GSM8906301","GSM8905454","GSM8905695","GSM8906300","GSM8905453","GSM8905452","GSM8905694","GSM8905693","GSM8905451","GSM8905692","GSM8905450","GSM8906309","GSM8906308","GSM8906307","GSM8906306","GSM8905459","GSM8906305","GSM8905458","GSM8905644","GSM8905402","GSM8905886","GSM8905401","GSM8905885","GSM8905643","GSM8905400","GSM8905884","GSM8905642","GSM8905641","GSM8905883","GSM8905882","GSM8905640","GSM8905881","GSM8905880","GSM8905409","GSM8905408","GSM8905649","GSM8905407","GSM8905406","GSM8905648","GSM8905647","GSM8905405","GSM8905889","GSM8905646","GSM8905404","GSM8905888","GSM8905403","GSM8905887","GSM8905645","GSM8905875","GSM8905633","GSM8905632","GSM8905874","GSM8905873","GSM8905631","GSM8905630","GSM8905872","GSM8905871","GSM8905870","GSM8905639","GSM8905638","GSM8905879","GSM8905637","GSM8905878","GSM8905636","GSM8905635","GSM8905877","GSM8905876","GSM8905634","GSM8905424","GSM8905666","GSM8905423","GSM8905665","GSM8905664","GSM8905422","GSM8905421","GSM8905663","GSM8905420","GSM8905662","GSM8905661","GSM8905660","GSM8905429","GSM8905428","GSM8905669","GSM8905427","GSM8905426","GSM8905668","GSM8905667","GSM8905425","GSM8905655","GSM8905413","GSM8905897","GSM8905412","GSM8905896","GSM8905654","GSM8905653","GSM8905411","GSM8905895","GSM8905652","GSM8905410","GSM8905894","GSM8905893","GSM8905651","GSM8905650","GSM8905892","GSM8905891","GSM8905890","GSM8905419","GSM8905418","GSM8905417","GSM8905659","GSM8905658","GSM8905416","GSM8905415","GSM8905899","GSM8905657","GSM8905898","GSM8905656","GSM8905414","GSM8905842","GSM8905600","GSM8905841","GSM8905840","GSM8905608","GSM8905607","GSM8905849","GSM8905606","GSM8905848","GSM8905847","GSM8905605","GSM8905604","GSM8905846","GSM8905845","GSM8905603","GSM8905844","GSM8905602","GSM8905601","GSM8905843","GSM8905609","GSM8905831","GSM8905830","GSM8905839","GSM8905838","GSM8905837","GSM8905836","GSM8905835","GSM8905834","GSM8905833","GSM8905832","GSM8905864","GSM8905622","GSM8905621","GSM8905863","GSM8905862","GSM8905620","GSM8905861","GSM8905860","GSM8905629","GSM8905628","GSM8905627","GSM8905869","GSM8905626","GSM8905868","GSM8905867","GSM8905625","GSM8905624","GSM8905866","GSM8905865","GSM8905623","GSM8905853","GSM8905611","GSM8905610","GSM8905852","GSM8905851","GSM8905850","GSM8905619","GSM8905618","GSM8905859","GSM8905617","GSM8905858","GSM8905616","GSM8905615","GSM8905857","GSM8905856","GSM8905614","GSM8905855","GSM8905613","GSM8905612","GSM8905854","GSM8905806","GSM8905805","GSM8905804","GSM8905803","GSM8905802","GSM8905801","GSM8905800","GSM8905809","GSM8905808","GSM8905807","GSM8905820","GSM8905828","GSM8905827","GSM8905826","GSM8905825","GSM8905824","GSM8905823","GSM8905822","GSM8905821","GSM8905829","GSM8905817","GSM8905816","GSM8905815","GSM8905814","GSM8905813","GSM8905812","GSM8905811",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