{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294478/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294478"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [bulk RNA-seq]","description":"Extreme metabolic adaptations can elucidate genetic programs governing mammalian metabolism. Here we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory elements (CREs) and metabolic programs. We characterized mouse hypothalamus gene expression and chromatin dynamics across fed, fasted, and refed states, then used comparative genomics of hibernating versus non-hibernating lineages to identify cis-elements with convergent changes in hibernators. Multi-omics approaches pinpointed CREs, hub genes, regulatory programs, and cell types underlying lineage divergence. Hibernators accumulated loss-of-function effects for CREs regulating hypothalamic responses, and the refeeding period after fasting served as a key phase for molecular processes with convergent evolutionary changes. This work provides a genetic framework for harnessing hibernator adaptations to understand human metabolic control. Convergent signals define cis-regulatory mechanisms behind food scarcity responses and hibernator-homeotherm divergence.","dates":{"publication":"2026/04/01"},"accession":"GSE294478","cross_references":{"GSM":["GSM8907740","GSM8907741","GSM8907720","GSM8907742","GSM8907743","GSM8907721","GSM8907744","GSM8907722","GSM8907723","GSM8907745","GSM8907746","GSM8907724","GSM8907747","GSM8907725","GSM8907726","GSM8907748","GSM8907749","GSM8907727","GSM8907728","GSM8907729","GSM8907730","GSM8907731","GSM8907732","GSM8907733","GSM8907734","GSM8907735","GSM8907736","GSM8907737","GSM8907738","GSM8907739"],"GPL":["24247"],"GSE":["294478"],"taxon":["Mus musculus"]}}