{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294535"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice[part5]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294535","cross_references":{"GSM":["GSM8909840","GSM8909842","GSM8909841","GSM8909844","GSM8909843","GSM8909846","GSM8909845","GSM8909848","GSM8909847","GSM8909849","GSM8909831","GSM8909830","GSM8909833","GSM8909832","GSM8909835","GSM8909834","GSM8909837","GSM8909836","GSM8909839","GSM8909838","GSM8909862","GSM8909861","GSM8909864","GSM8909863","GSM8910613","GSM8909866","GSM8909865","GSM8910612","GSM8910611","GSM8909868","GSM8909867","GSM8910610","GSM8910617","GSM8910616","GSM8910615","GSM8910614","GSM8909860","GSM8910619","GSM8910618","GSM8909869","GSM8909851","GSM8909850","GSM8909853","GSM8909852","GSM8909855","GSM8910602","GSM8910601","GSM8909854","GSM8910600","GSM8909857","GSM8909856","GSM8910606","GSM8910605","GSM8910604","GSM8910603","GSM8910609","GSM8910608","GSM8910607","GSM8909859","GSM8909858","GSM8909800","GSM8909802","GSM8909801","GSM8909804","GSM8909803","GSM8909806","GSM8909805","GSM8909808","GSM8909807","GSM8909809","GSM8909820","GSM8909822","GSM8909821","GSM8909824","GSM8909823","GSM8909826","GSM8909825","GSM8909828","GSM8909827","GSM8909829","GSM8909811","GSM8909810","GSM8909813","GSM8909812","GSM8909815","GSM8909814","GSM8909817","GSM8909816","GSM8909819","GSM8909818","GSM8910199","GSM8910190","GSM8910194","GSM8910193","GSM8910192","GSM8910191","GSM8910198","GSM8910197","GSM8910196","GSM8910195","GSM8910189","GSM8910188","GSM8910183","GSM8910182","GSM8910181","GSM8910180","GSM8910187","GSM8910186","GSM8910185","GSM8910184","GSM8910158","GSM8910157","GSM8910399","GSM8910156","GSM8910398","GSM8910397","GSM8910155","GSM8910159","GSM8910392","GSM8910150","GSM8910391","GSM8910390","GSM8910154","GSM8910396","GSM8910153","GSM8910395","GSM8910394","GSM8910152","GSM8910151","GSM8910393","GSM8910389","GSM8910147","GSM8910388","GSM8910146","GSM8910145","GSM8910387","GSM8910386","GSM8910144","GSM8910149","GSM8910148","GSM8910381","GSM8910380","GSM8910385","GSM8910143","GSM8910142","GSM8910384","GSM8910383","GSM8910141","GSM8910382","GSM8910140","GSM8910179","GSM8910178","GSM8910177","GSM8910172","GSM8910171","GSM8910170","GSM8910176","GSM8910175","GSM8910174","GSM8910173","GSM8910169","GSM8910168","GSM8910167","GSM8910166","GSM8910161","GSM8910160","GSM8910165","GSM8910164","GSM8910163","GSM8910162","GSM8910598","GSM8910114","GSM8910356","GSM8910113","GSM8910597","GSM8910355","GSM8910354","GSM8910112","GSM8910596","GSM8910111","GSM8910595","GSM8910353","GSM8910118","GSM8910359","GSM8910117","GSM8910116","GSM8910358","GSM8910357","GSM8910115","GSM8910599","GSM8910119","GSM8910590","GSM8910110","GSM8910594","GSM8910352","GSM8910351","GSM8910593","GSM8910592","GSM8910350","GSM8910591","GSM8910345","GSM8910103","GSM8910587","GSM8910102","GSM8910586","GSM8910344","GSM8910343","GSM8910585","GSM8910101","GSM8910342","GSM8910100","GSM8910584","GSM8910349","GSM8910107","GSM8910348","GSM8910106","GSM8910589","GSM8910105","GSM8910347","GSM8910588","GSM8910346","GSM8910104","GSM8910109","GSM8910108","GSM8910583","GSM8910341","GSM8910340","GSM8910582","GSM8910581","GSM8910580","GSM8910136","GSM8910378","GSM8910377","GSM8910135","GSM8910134","GSM8910376","GSM8910133","GSM8910375","GSM8910139","GSM8910138","GSM8910137","GSM8910379","GSM8910370","GSM8910374","GSM8910132","GSM8910131","GSM8910373","GSM8910130","GSM8910372","GSM8910371","GSM8910125","GSM8910367","GSM8910366","GSM8910124","GSM8910365","GSM8910123","GSM8910122","GSM8910364","GSM8910129","GSM8910128","GSM8910369","GSM8910127","GSM8910368","GSM8910126","GSM8910363","GSM8910121","GSM8910362","GSM8910120","GSM8910361","GSM8910360","GSM8910554","GSM8910312","GSM8910311","GSM8910553","GSM8910552","GSM8910310","GSM8910551","GSM8910558","GSM8910316","GSM8910557","GSM8910315","GSM8910314","GSM8910556","GSM8910555","GSM8910313","GSM8910319","GSM8910318","GSM8910317","GSM8910559","GSM8910550","GSM8910543","GSM8909796","GSM8909795","GSM8910542","GSM8909798","GSM8910541","GSM8910540","GSM8909797","GSM8910305","GSM8910547","GSM8910546","GSM8909799","GSM8910303","GSM8910545","GSM8910544","GSM8910309","GSM8910308","GSM8909790","GSM8910549","GSM8910307","GSM8910548","GSM8910306","GSM8909792","GSM8909791","GSM8909794","GSM8909793","GSM8910334","GSM8910576","GSM8910575","GSM8910333","GSM8910574","GSM8910332","GSM8910331","GSM8910573","GSM8910338","GSM8910337","GSM8910579","GSM8910578","GSM8910336","GSM8910577","GSM8910335","GSM8910339","GSM8910572","GSM8910330","GSM8910571","GSM8910570","GSM8910323","GSM8910565","GSM8910322","GSM8910564","GSM8910563","GSM8910321","GSM8910320","GSM8910562","GSM8910569","GSM8910327","GSM8910568","GSM8910326","GSM8910325","GSM8910567","GSM8910566","GSM8910324","GSM8910329","GSM8910328","GSM8910561","GSM8910560","GSM8909763","GSM8910510","GSM8909762","GSM8909765","GSM8909764","GSM8910514","GSM8909767","GSM8909766","GSM8910513","GSM8910512","GSM8909769","GSM8910511","GSM8909768","GSM8910518","GSM8910517","GSM8910516","GSM8910515","GSM8909761","GSM8909760","GSM8910519","GSM8909994","GSM8909752","GSM8909993","GSM8909751","GSM8909996","GSM8909754","GSM8909753","GSM8909995","GSM8909756","GSM8910503","GSM8909998","GSM8909755","GSM8909997","GSM8910502","GSM8909758","GSM8910501","GSM8909999","GSM8910500","GSM8909757","GSM8910507","GSM8910506","GSM8910505","GSM8910504","GSM8909990","GSM8909750","GSM8910509","GSM8909992","GSM8910508","GSM8909991","GSM8909759","GSM8909785","GSM8910532","GSM8909784","GSM8909787","GSM8910530","GSM8909786","GSM8910536","GSM8909789","GSM8910535","GSM8909788","GSM8910534","GSM8910539","GSM8910538","GSM8910537","GSM8909781","GSM8909780","GSM8909783","GSM8909782","GSM8910521","GSM8909774","GSM8909773","GSM8910520","GSM8909776","GSM8909775","GSM8909778","GSM8910524","GSM8909777","GSM8909779","GSM8910522","GSM8910528","GSM8910526","GSM8909770","GSM8909772","GSM8909771","GSM8909961","GSM8909960","GSM8909721","GSM8909963","GSM8909962","GSM8909720","GSM8909965","GSM8909723","GSM8909964","GSM8909722","GSM8909967","GSM8909725","GSM8909724","GSM8909966","GSM8909727","GSM8909969","GSM8909968","GSM8909726","GSM8909729","GSM8909728","GSM8909950","GSM8909710","GSM8909952","GSM8909951","GSM8909954","GSM8909712","GSM8909953","GSM8909711","GSM8909956","GSM8909714","GSM8909713","GSM8909955","GSM8909716","GSM8909958","GSM8909715","GSM8909957","GSM8909718","GSM8909959","GSM8909717","GSM8909719","GSM8909741","GSM8909983","GSM8909982","GSM8909740","GSM8909985","GSM8909743","GSM8909984","GSM8909742","GSM8909987","GSM8909745","GSM8909744","GSM8909986","GSM8909747","GSM8909989","GSM8909988","GSM8909746","GSM8909981","GSM8909980","GSM8909749","GSM8909748","GSM8909730","GSM8909972","GSM8909971","GSM8909974","GSM8909732","GSM8909973","GSM8909731","GSM8909976","GSM8909734","GSM8909733","GSM8909975","GSM8909736","GSM8909978","GSM8909735","GSM8909977","GSM8909970","GSM8909738","GSM8909979","GSM8909737","GSM8909739","GSM8909921","GSM8909920","GSM8909923","GSM8909922","GSM8909925","GSM8909924","GSM8909927","GSM8909926","GSM8909929","GSM8909928","GSM8909910","GSM8909912","GSM8909911","GSM8909914","GSM8909913","GSM8909916","GSM8909915","GSM8909918","GSM8909917","GSM8909919","GSM8909941","GSM8909940","GSM8909701","GSM8909943","GSM8909942","GSM8909700","GSM8909945","GSM8909703","GSM8909944","GSM8909702","GSM8909947","GSM8909705","GSM8909704","GSM8909946","GSM8909707","GSM8909949","GSM8909948","GSM8909706","GSM8909709","GSM8909708","GSM8909930","GSM8909932","GSM8909931","GSM8909934","GSM8909933","GSM8909936","GSM8909935","GSM8909938","GSM8909937","GSM8909939","GSM8909901","GSM8909900","GSM8909903","GSM8909902","GSM8909905","GSM8909904","GSM8909907","GSM8909906","GSM8909909","GSM8909908","GSM8910079","GSM8910078","GSM8910073","GSM8910072","GSM8910071","GSM8910070","GSM8910077","GSM8910076","GSM8910075","GSM8910074","GSM8910069","GSM8910068","GSM8910067","GSM8910062","GSM8910061","GSM8910060","GSM8910066","GSM8910065","GSM8910064","GSM8910063","GSM8910091","GSM8910090","GSM8910095","GSM8910094","GSM8910093","GSM8910092","GSM8910099","GSM8910098","GSM8910097","GSM8910096","GSM8910089","GSM8910080","GSM8910084","GSM8910083","GSM8910082","GSM8910081","GSM8910088","GSM8910087","GSM8910086","GSM8910085","GSM8910279","GSM8910037","GSM8910036","GSM8910278","GSM8910277","GSM8910035","GSM8910276","GSM8910034","GSM8910039","GSM8910038","GSM8910271","GSM8910270","GSM8910033","GSM8910275","GSM8910274","GSM8910032","GSM8910031","GSM8910273","GSM8910030","GSM8910272","GSM8910268","GSM8910026","GSM8910025","GSM8910267","GSM8910266","GSM8910024","GSM8910265","GSM8910023","GSM8910029","GSM8910028","GSM8910027","GSM8910269","GSM8910260","GSM8910022","GSM8910264","GSM8910263","GSM8910021","GSM8910262","GSM8910020","GSM8910261","GSM8910059","GSM8910058","GSM8910057","GSM8910056","GSM8910051","GSM8910293","GSM8910050","GSM8910292","GSM8910291","GSM8910290","GSM8910297","GSM8910055","GSM8910054","GSM8910296","GSM8910053","GSM8910295","GSM8910294","GSM8910052","GSM8910048","GSM8910047","GSM8910289","GSM8910288","GSM8910046","GSM8910045","GSM8910287","GSM8910049","GSM8910282","GSM8910040","GSM8910281","GSM8910280","GSM8910286","GSM8910044","GSM8910285","GSM8910043","GSM8910042","GSM8910284","GSM8910283","GSM8910041","GSM8910477","GSM8910235","GSM8910234","GSM8910476","GSM8910475","GSM8910233","GSM8910474","GSM8910232","GSM8910239","GSM8910238","GSM8910237","GSM8910479","GSM8910236","GSM8910478","GSM8910231","GSM8910473","GSM8910472","GSM8910230","GSM8910471","GSM8910470","GSM8910466","GSM8910224","GSM8910465","GSM8910223","GSM8910222","GSM8910464","GSM8910463","GSM8910221","GSM8910228","GSM8910469","GSM8910227","GSM8910468","GSM8910226","GSM8910225","GSM8910467","GSM8910229","GSM8910220","GSM8910462","GSM8910461","GSM8910460","GSM8910257","GSM8910015","GSM8910499","GSM8910256","GSM8910014","GSM8910498","GSM8910013","GSM8910497","GSM8910255","GSM8910254","GSM8910496","GSM8910012","GSM8910019","GSM8910018","GSM8910259","GSM8910017","GSM8910016","GSM8910258","GSM8910491","GSM8910490","GSM8910495","GSM8910011","GSM8910253","GSM8910010","GSM8910494","GSM8910252","GSM8910251","GSM8910493","GSM8910492","GSM8910250","GSM8910488","GSM8910246","GSM8910004","GSM8910245","GSM8910487","GSM8910003","GSM8910002","GSM8910486","GSM8910244","GSM8910485","GSM8910243","GSM8910001","GSM8910008","GSM8910007","GSM8910249","GSM8910248","GSM8910006","GSM8910005","GSM8910489","GSM8910247","GSM8910009","GSM8910480","GSM8910242","GSM8910000","GSM8910484","GSM8910483","GSM8910241","GSM8910240","GSM8910482","GSM8910481","GSM8910675","GSM8910433","GSM8909686","GSM8910674","GSM8910432","GSM8909685","GSM8910431","GSM8909688","GSM8910673","GSM8909687","GSM8910672","GSM8910430","GSM8910437","GSM8910679","GSM8910678","GSM8909689","GSM8910436","GSM8910677","GSM8910435","GSM8910434","GSM8910676","GSM8909680","GSM8910439","GSM8910438","GSM8909682","GSM8909681","GSM8909684","GSM8909683","GSM8910671","GSM8910670","GSM8910422","GSM8910664","GSM8910663","GSM8910421","GSM8910420","GSM8910662","GSM8909677","GSM8910661","GSM8909679","GSM8910426","GSM8910668","GSM8910425","GSM8909678","GSM8910667","GSM8910666","GSM8910424","GSM8910423","GSM8910665","GSM8910429","GSM8910428","GSM8910669","GSM8910427","GSM8910660","GSM8910213","GSM8910455","GSM8910454","GSM8910212","GSM8910211","GSM8910453","GSM8910452","GSM8910210","GSM8910217","GSM8910459","GSM8910216","GSM8910458","GSM8910457","GSM8910215","GSM8910214","GSM8910456","GSM8910219","GSM8910218","GSM8910451","GSM8910450","GSM8910202","GSM8910686","GSM8910444","GSM8909697","GSM8910443","GSM8909696","GSM8910201","GSM8910685","GSM8910442","GSM8910200","GSM8909699","GSM8910684","GSM8909698","GSM8910683","GSM8910441","GSM8910448","GSM8910206","GSM8910205","GSM8910447","GSM8910446","GSM8910688","GSM8910204","GSM8910445","GSM8910687","GSM8910203","GSM8910209","GSM8910208","GSM8909691","GSM8909690","GSM8910449","GSM8910207","GSM8909693","GSM8909692","GSM8909695","GSM8909694","GSM8910440","GSM8910682","GSM8910681","GSM8910680","GSM8909884","GSM8910631","GSM8910630","GSM8909883","GSM8909886","GSM8909885","GSM8909888","GSM8910635","GSM8910634","GSM8909887","GSM8910633","GSM8910632","GSM8909889","GSM8910639","GSM8910638","GSM8910637","GSM8910636","GSM8909880","GSM8909882","GSM8909881","GSM8910620","GSM8909873","GSM8909872","GSM8909875","GSM8909874","GSM8910624","GSM8909877","GSM8910623","GSM8909876","GSM8909879","GSM8910622","GSM8910621","GSM8909878","GSM8910628","GSM8910627","GSM8910626","GSM8910625","GSM8909871","GSM8909870","GSM8910629","GSM8910411","GSM8910653","GSM8910652","GSM8910410","GSM8910651","GSM8910650","GSM8910657","GSM8910415","GSM8910414","GSM8910656","GSM8910655","GSM8910413","GSM8910654","GSM8910412","GSM8910419","GSM8910418","GSM8910417","GSM8910659","GSM8910658","GSM8910416","GSM8910400","GSM8910642","GSM8909895","GSM8909894","GSM8910641","GSM8910640","GSM8909897","GSM8909896","GSM8910646","GSM8909899","GSM8910404","GSM8910403","GSM8910645","GSM8909898","GSM8910402","GSM8910644","GSM8910643","GSM8910401","GSM8910408","GSM8910649","GSM8910407","GSM8910406","GSM8910648","GSM8910405","GSM8910647","GSM8909891","GSM8909890","GSM8909893","GSM8910409","GSM8909892"],"GPL":["24247"],"GSE":["294535"],"taxon":["Mus musculus"]}}