{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294583/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294583"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Cold-inducible RNA-binding protein promotes lung fibroblast activation via TLR2/4-dependent IL-6 signaling: implications in pulmonary fibrosis","description":"This study investigates the role of Cold-inducible RNA-binding protein (CIRBP) in the pathogenesis of pulmonary fibrosis. Using RNA-seq, we analyzed gene expression changes in primary mouse lung fibroblasts stimulated with recombinant CIRBP or PBS control. CIRBP significantly upregulated cytokine-related gene expression, including IL-6, and promoted collagen production and fibroblast proliferation via TLR2/4 pathways.","dates":{"publication":"2026/03/11"},"accession":"GSE294583","cross_references":{"GSM":["GSM8911845","GSM8911844","GSM8911843","GSM8911842","GSM8911847","GSM8911846"],"GPL":["24247"],"GSE":["294583"],"taxon":["Mus musculus"],"PMID":["[41667819]"]}}