{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294609/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294609"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Skin commensal Staphylococcus promotes systemic reconfiguration of Vγ6+ γδT cells","description":"Skin-resident Staphylococcus aureus, a common human commensal, can shape systemic immune responses without provoking inflammation in mice. This study demonstrates that topical skin colonization with live S. aureus robustly expands IL-17-producing Vγ6⁺ γδT17 cells both locally in the dermis and across distant tissues, including mucosal, lymphoid, and metabolic organs. This systemic reconfiguration is IL-1R-dependent yet independent of IL-23, TLR2, or the microbiota. Transcriptomic profiling reveals a transitional state in dermal Vγ6⁺ γδT cells, marked by changes in tissue-residency and migration-associated genes. Local proliferation, lymphatic trafficking and long-term recirculation sustain this response, even without systemic bacterial dissemination. These findings uncover a previously unrecognized allostatic process by which localized microbial signals recalibrate systemic immunological setpoints. The study expands our understanding of γδT17 cell dynamics and highlights their potential in tuning organismal fitness.","dates":{"publication":"2026/04/01"},"accession":"GSE294609","cross_references":{"GSM":["GSM8912458","GSM8912459","GSM8912454","GSM8912455","GSM8912456","GSM8912457","GSM8912460"],"GPL":["21103"],"GSE":["294609"],"taxon":["Mus musculus"]}}