{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294643/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294643"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part6]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294643","cross_references":{"GSM":["GSM8913290","GSM8913291","GSM8913292","GSM8913297","GSM8913298","GSM8913299","GSM8913293","GSM8913294","GSM8913295","GSM8913296","GSM8914119","GSM8914115","GSM8913268","GSM8914116","GSM8913269","GSM8914117","GSM8914118","GSM8914111","GSM8913264","GSM8914112","GSM8913265","GSM8913266","GSM8914113","GSM8914114","GSM8913267","GSM8913260","GSM8913261","GSM8913262","GSM8913263","GSM8914110","GSM8914108","GSM8914109","GSM8913499","GSM8914104","GSM8913257","GSM8914105","GSM8913258","GSM8913259","GSM8914106","GSM8914107","GSM8913490","GSM8913495","GSM8913253","GSM8914100","GSM8913496","GSM8914101","GSM8913254","GSM8914102","GSM8913255","GSM8913497","GSM8913498","GSM8914103","GSM8913256","GSM8913491","GSM8913492","GSM8913250","GSM8913493","GSM8913251","GSM8913252","GSM8913494","GSM8913280","GSM8913281","GSM8913286","GSM8913287","GSM8913288","GSM8913289","GSM8913282","GSM8913283","GSM8913284","GSM8913285","GSM8913279","GSM8914126","GSM8914127","GSM8913270","GSM8913275","GSM8914122","GSM8914123","GSM8913276","GSM8914124","GSM8913277","GSM8914125","GSM8913278","GSM8913271","GSM8913272","GSM8914120","GSM8913273","GSM8914121","GSM8913274","GSM8913228","GSM8913229","GSM8913224","GSM8913466","GSM8913467","GSM8913225","GSM8913226","GSM8913468","GSM8913469","GSM8913227","GSM8913220","GSM8913462","GSM8913221","GSM8913463","GSM8913464","GSM8913222","GSM8913223","GSM8913465","GSM8913460","GSM8913461","GSM8913459","GSM8913217","GSM8913218","GSM8913219","GSM8913455","GSM8913213","GSM8913697","GSM8913698","GSM8913456","GSM8913214","GSM8913215","GSM8913699","GSM8913457","GSM8913458","GSM8913216","GSM8913693","GSM8913451","GSM8913452","GSM8913694","GSM8913210","GSM8913453","GSM8913211","GSM8913695","GSM8913212","GSM8913696","GSM8913454","GSM8913690","GSM8913691","GSM8913450","GSM8913692","GSM8913246","GSM8913488","GSM8913247","GSM8913489","GSM8913248","GSM8913249","GSM8913484","GSM8913242","GSM8913243","GSM8913485","GSM8913244","GSM8913486","GSM8913487","GSM8913245","GSM8913480","GSM8913481","GSM8913482","GSM8913240","GSM8913241","GSM8913483","GSM8913239","GSM8913235","GSM8913477","GSM8913478","GSM8913236","GSM8913479","GSM8913237","GSM8913238","GSM8913473","GSM8913231","GSM8913232","GSM8913474","GSM8913475","GSM8913233","GSM8913476","GSM8913234","GSM8913470","GSM8913471","GSM8913472","GSM8913230","GSM8913668","GSM8913426","GSM8913427","GSM8913669","GSM8913428","GSM8913429","GSM8913664","GSM8913422","GSM8913665","GSM8913423","GSM8913424","GSM8913666","GSM8913667","GSM8913425","GSM8913660","GSM8913661","GSM8913662","GSM8913420","GSM8913421","GSM8913663","GSM8913899","GSM8913415","GSM8913657","GSM8913658","GSM8913416","GSM8913659","GSM8913417","GSM8913418","GSM8913653","GSM8913411","GSM8913895","GSM8913412","GSM8913896","GSM8913654","GSM8913413","GSM8913897","GSM8913655","GSM8913656","GSM8913898","GSM8913414","GSM8913419","GSM8913891","GSM8913650","GSM8913892","GSM8913893","GSM8913651","GSM8913410","GSM8913894","GSM8913652","GSM8913890","GSM8913206","GSM8913448","GSM8913449","GSM8913207","GSM8913208","GSM8913209","GSM8913444","GSM8913202","GSM8913686","GSM8913203","GSM8913687","GSM8913445","GSM8913204","GSM8913688","GSM8913446","GSM8913447","GSM8913205","GSM8913689","GSM8913682","GSM8913440","GSM8913441","GSM8913683","GSM8913684","GSM8913200","GSM8913442","GSM8913201","GSM8913685","GSM8913443","GSM8913680","GSM8913681","GSM8913679","GSM8913437","GSM8913438","GSM8913439","GSM8913675","GSM8913676","GSM8913677","GSM8913678","GSM8913436","GSM8913671","GSM8913672","GSM8913673","GSM8913674","GSM8913670","GSM8913624","GSM8913866","GSM8913867","GSM8913625","GSM8913868","GSM8913626","GSM8913627","GSM8913869","GSM8913862","GSM8913620","GSM8913621","GSM8913863","GSM8913622","GSM8913864","GSM8913865","GSM8913623","GSM8913628","GSM8913629","GSM8913860","GSM8913861","GSM8913613","GSM8913855","GSM8913856","GSM8913614","GSM8913615","GSM8913857","GSM8913616","GSM8913858","GSM8913851","GSM8913610","GSM8913852","GSM8913853","GSM8913611","GSM8913854","GSM8913612","GSM8913859","GSM8913617","GSM8913618","GSM8913619","GSM8913850","GSM8913404","GSM8913888","GSM8913646","GSM8913647","GSM8913889","GSM8913405","GSM8913648","GSM8913406","GSM8913407","GSM8913649","GSM8913642","GSM8913400","GSM8913884","GSM8913401","GSM8913885","GSM8913643","GSM8913644","GSM8913886","GSM8913402","GSM8913887","GSM8913645","GSM8913403","GSM8913408","GSM8913409","GSM8913880","GSM8913881","GSM8913882","GSM8913640","GSM8913641","GSM8913883","GSM8913877","GSM8913635","GSM8913636","GSM8913878","GSM8913879","GSM8913637","GSM8913638","GSM8913873","GSM8913631","GSM8913874","GSM8913632","GSM8913633","GSM8913875","GSM8913876","GSM8913634","GSM8913639","GSM8913870","GSM8913871","GSM8913630","GSM8913872","GSM8913822","GSM8913824","GSM8913826","GSM8913827","GSM8913828","GSM8913829","GSM8913811","GSM8913813","GSM8913819","GSM8913815","GSM8913817","GSM8913844","GSM8913602","GSM8913845","GSM8913603",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