{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294665"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part7]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294665","cross_references":{"GSM":["GSM8915281","GSM8915280","GSM8915283","GSM8915041","GSM8915282","GSM8915040","GSM8915047","GSM8915289","GSM8915288","GSM8915046","GSM8915049","GSM8915048","GSM8915285","GSM8915043","GSM8915042","GSM8915284","GSM8915045","GSM8915287","GSM8915286","GSM8915044","GSM8915039","GSM8915270","GSM8915030","GSM8915272","GSM8915271","GSM8915036","GSM8915278","GSM8915277","GSM8915035","GSM8915038","GSM8915279","GSM8915037","GSM8915274","GSM8915032","GSM8915031","GSM8915273","GSM8915276","GSM8915034","GSM8915033","GSM8915275","GSM8915061","GSM8915060","GSM8915063","GSM8915062","GSM8915069","GSM8915068","GSM8915065","GSM8915064","GSM8915067","GSM8915066","GSM8915050","GSM8915292","GSM8915291","GSM8915294","GSM8915052","GSM8915051","GSM8915293","GSM8915290","GSM8915058","GSM8915299","GSM8915057","GSM8915059","GSM8915054","GSM8915296","GSM8915053","GSM8915295","GSM8915056","GSM8915298","GSM8915297","GSM8915055","GSM8915007","GSM8915249","GSM8915248","GSM8915006","GSM8915009","GSM8915008","GSM8915245","GSM8915003","GSM8915002","GSM8915244","GSM8915005","GSM8915247","GSM8915246","GSM8915004","GSM8915241","GSM8915240","GSM8915243","GSM8915001","GSM8915242","GSM8915000","GSM8915238","GSM8915237","GSM8915239","GSM8915470","GSM8915234","GSM8915476","GSM8915475","GSM8915233","GSM8915236","GSM8915478","GSM8915477","GSM8915235","GSM8915472","GSM8915230","GSM8915471","GSM8915474","GSM8915232","GSM8915231","GSM8915473","GSM8915029","GSM8915028","GSM8915261","GSM8915260","GSM8915025","GSM8915267","GSM8915266","GSM8915024","GSM8915027","GSM8915269","GSM8915268","GSM8915026","GSM8915263","GSM8915021","GSM8915262","GSM8915020","GSM8915265","GSM8915023","GSM8915022","GSM8915264","GSM8915018","GSM8915259","GSM8915017","GSM8915019","GSM8915250","GSM8915256","GSM8915014","GSM8915013","GSM8915255","GSM8915016","GSM8915258","GSM8915257","GSM8915015","GSM8915010","GSM8915252","GSM8915251","GSM8915254","GSM8915012","GSM8915011","GSM8915253","GSM8915209","GSM8915208","GSM8915205","GSM8914599","GSM8915447","GSM8915446","GSM8915204","GSM8915449","GSM8915207","GSM8915448","GSM8915206","GSM8914590","GSM8914595","GSM8915443","GSM8915201","GSM8915442","GSM8914596","GSM8915200","GSM8915445","GSM8915203","GSM8914597","GSM8914598","GSM8915202","GSM8915444","GSM8914591","GSM8914592","GSM8914593","GSM8915441","GSM8915440","GSM8914594","GSM8915439","GSM8914588","GSM8915436","GSM8914589","GSM8915435","GSM8915438","GSM8915437","GSM8914584","GSM8915432","GSM8915431","GSM8914585","GSM8915434","GSM8914586","GSM8914587","GSM8915433","GSM8914580","GSM8914581","GSM8914582","GSM8915430","GSM8914583","GSM8915469","GSM8915227","GSM8915468","GSM8915226","GSM8915229","GSM8915228","GSM8915465","GSM8915223","GSM8915222","GSM8915464","GSM8915225","GSM8915467","GSM8915466","GSM8915224","GSM8915461","GSM8915460","GSM8915463","GSM8915221","GSM8915220","GSM8915462","GSM8915219","GSM8915216","GSM8915458","GSM8915457","GSM8915215","GSM8915218","GSM8915217","GSM8915459","GSM8915454","GSM8915212","GSM8915211","GSM8915453","GSM8915214","GSM8915456","GSM8915213","GSM8915455","GSM8915450","GSM8915452","GSM8915210","GSM8915451","GSM8914559","GSM8915407","GSM8915406","GSM8915409","GSM8915408","GSM8914798","GSM8914555","GSM8915403","GSM8915402","GSM8914556","GSM8914797","GSM8915405","GSM8914557","GSM8914558","GSM8914799","GSM8915404","GSM8914794","GSM8914551","GSM8914552","GSM8914793","GSM8914796","GSM8914553","GSM8915401","GSM8915400","GSM8914554","GSM8914795","GSM8914790","GSM8914792","GSM8914550","GSM8914791","GSM8914548","GSM8914549","GSM8914787","GSM8914544","GSM8914545","GSM8914786","GSM8914546","GSM8914789","GSM8914547","GSM8914788","GSM8914783","GSM8914540","GSM8914541","GSM8914782","GSM8914785","GSM8914542","GSM8914784","GSM8914543","GSM8914781","GSM8914780","GSM8915429","GSM8915428","GSM8915425","GSM8914577","GSM8914578","GSM8915424","GSM8914579","GSM8915427","GSM8915426","GSM8914573","GSM8915421","GSM8915420","GSM8914574","GSM8914575","GSM8915423","GSM8915422","GSM8914576","GSM8914570","GSM8914571","GSM8914572","GSM8915418","GSM8915417","GSM8915419","GSM8915414","GSM8914566","GSM8914567","GSM8915413","GSM8914568","GSM8915416","GSM8914569","GSM8915415","GSM8914562","GSM8915410","GSM8914563","GSM8914564","GSM8915412","GSM8915411","GSM8914565","GSM8914560","GSM8914561","GSM8914758","GSM8914515","GSM8914999","GSM8914516","GSM8914757","GSM8914517","GSM8914518","GSM8914759","GSM8914996","GSM8914754","GSM8914511","GSM8914512","GSM8914753","GSM8914995","GSM8914756","GSM8914513","GSM8914998","GSM8914997","GSM8914514","GSM8914755","GSM8914519","GSM8914750","GSM8914992","GSM8914991","GSM8914994","GSM8914752","GSM8914993","GSM8914510","GSM8914751","GSM8914990","GSM8914747","GSM8914504","GSM8914989","GSM8914988","GSM8914505","GSM8914746","GSM8914506","GSM8914749","GSM8914507","GSM8914748","GSM8914985","GSM8914743","GSM8914500","GSM8914984","GSM8914501","GSM8914742","GSM8914987","GSM8914745","GSM8914502","GSM8914744","GSM8914986","GSM8914503","GSM8914508","GSM8914509","GSM8914981","GSM8914980","GSM8914741","GSM8914983","GSM8914982","GSM8914740","GSM8914537","GSM8914538","GSM8914779","GSM8914539","GSM8914776","GSM8914533","GSM8914534","GSM8914775","GSM8914778","GSM8914535","GSM8914536","GSM8914777","GSM8914772","GSM8914530","GSM8914771","GSM8914774","GSM8914531","GSM8914532","GSM8914773","GSM8914770","GSM8914526","GSM8914769","GSM8914527","GSM8914768","GSM8914528","GSM8914529","GSM8914765","GSM8914522","GSM8914764","GSM8914523","GSM8914767","GSM8914524","GSM8914525","GSM8914766","GSM8914761","GSM8914760","GSM8914763","GSM8914520","GSM8914521","GSM8914762","GSM8914956","GSM8914714","GSM8914713","GSM8914955","GSM8914716","GSM8914958","GSM8914715","GSM8914957","GSM8914710","GSM8914952","GSM8914951","GSM8914954","GSM8914712","GSM8914953","GSM8914711","GSM8914718","GSM8914959","GSM8914717","GSM8914719","GSM8914950","GSM8914945","GSM8914703","GSM8914944","GSM8914702","GSM8914947","GSM8914705","GSM8914704","GSM8914946","GSM8914941","GSM8914940","GSM8914701","GSM8914943","GSM8914942","GSM8914700","GSM8914707","GSM8914949","GSM8914948","GSM8914706","GSM8914709","GSM8914708","GSM8914736","GSM8914978","GSM8914735","GSM8914977","GSM8914738","GSM8914979","GSM8914737","GSM8914974","GSM8914732","GSM8914973","GSM8914731","GSM8914976","GSM8914734","GSM8914733","GSM8914975","GSM8914739","GSM8914970","GSM8914730","GSM8914972","GSM8914971","GSM8914967","GSM8914725","GSM8914724","GSM8914966","GSM8914727","GSM8914969","GSM8914968","GSM8914726","GSM8914721","GSM8914963","GSM8914962","GSM8914720","GSM8914965","GSM8914723","GSM8914964","GSM8914722","GSM8914729","GSM8914728","GSM8914961","GSM8914960","GSM8914912","GSM8914911","GSM8914914","GSM8914913","GSM8914910","GSM8914919","GSM8914916","GSM8914915","GSM8914918","GSM8914917","GSM8914901","GSM8914900","GSM8914903","GSM8914902","GSM8914909","GSM8914908","GSM8914905","GSM8914904","GSM8914907","GSM8914906","GSM8914934","GSM8914933","GSM8914936","GSM8914935","GSM8914930","GSM8914932","GSM8914931","GSM8914938","GSM8914937","GSM8914939","GSM8914923","GSM8914922","GSM8914925","GSM8914924","GSM8914921","GSM8914920","GSM8914927","GSM8914926","GSM8914929","GSM8914928","GSM8915193","GSM8915192","GSM8915195","GSM8915194","GSM8915191","GSM8915190","GSM8915197","GSM8915196","GSM8915199","GSM8915198","GSM8915160","GSM8915162","GSM8915161","GSM8915168","GSM8915167","GSM8915169","GSM8915164","GSM8915163","GSM8915166","GSM8915165","GSM8915391","GSM8915390","GSM8915151","GSM8915393","GSM8915392","GSM8915150","GSM8915157","GSM8915399","GSM8915156","GSM8915398","GSM8915159","GSM8915158","GSM8915153","GSM8915395","GSM8915394","GSM8915152","GSM8915397","GSM8915155","GSM8915154","GSM8915396","GSM8915182","GSM8915181","GSM8915184","GSM8915183","GSM8915180","GSM8915189","GSM8915186","GSM8915185","GSM8915188","GSM8915187","GSM8915171","GSM8915170","GSM8915173","GSM8915172","GSM8915179","GSM8915178","GSM8915175","GSM8915174","GSM8915177","GSM8915176","GSM8915128","GSM8915369","GSM8915127","GSM8915129","GSM8915360","GSM8915366","GSM8915124","GSM8915365","GSM8915123","GSM8915368","GSM8915126","GSM8915125","GSM8915367","GSM8915362","GSM8915120","GSM8915361","GSM8915122","GSM8915364","GSM8915363","GSM8915121","GSM8915359","GSM8915117","GSM8915116","GSM8915358","GSM8915119","GSM8915118","GSM8915113","GSM8915355","GSM8915354","GSM8915112","GSM8915357","GSM8915115","GSM8915114","GSM8915356","GSM8915351","GSM8915350","GSM8915111","GSM8915353","GSM8915110","GSM8915352","GSM8915149","GSM8915380","GSM8915382","GSM8915140","GSM8915381","GSM8915388","GSM8915146","GSM8915145","GSM8915387","GSM8915148","GSM8915389","GSM8915147","GSM8915142","GSM8915384","GSM8915383","GSM8915141","GSM8915386","GSM8915144","GSM8915385","GSM8915143","GSM8915139","GSM8915138","GSM8915371","GSM8915370","GSM8915377","GSM8915135","GSM8915134","GSM8915376","GSM8915137","GSM8915379","GSM8915136","GSM8915378","GSM8915131","GSM8915373","GSM8915130","GSM8915372","GSM8915133","GSM8915375","GSM8915374","GSM8915132","GSM8915329","GSM8915326","GSM8915325","GSM8914479","GSM8915328","GSM8915327","GSM8915322","GSM8915321","GSM8915324","GSM8915323","GSM8915320","GSM8915319","GSM8915318","GSM8915315","GSM8915314","GSM8915317","GSM8915316","GSM8915311","GSM8915310","GSM8915313","GSM8915312","GSM8915109","GSM8915348","GSM8915106","GSM8915105","GSM8915347","GSM8915108","GSM8915349","GSM8915107","GSM8914490","GSM8914491","GSM8915102","GSM8914496","GSM8915344","GSM8915343","GSM8914497","GSM8915101","GSM8914498","GSM8915346","GSM8915104","GSM8915345","GSM8914499","GSM8915103","GSM8914492","GSM8915340","GSM8914493","GSM8915342","GSM8915100","GSM8914494","GSM8914495","GSM8915341","GSM8914489","GSM8915337","GSM8915336","GSM8915339","GSM8915338","GSM8914480","GSM8914485","GSM8915333","GSM8914486","GSM8915332","GSM8914487","GSM8915335","GSM8915334","GSM8914488","GSM8914481","GSM8914482","GSM8915331","GSM8914483","GSM8914484","GSM8915330","GSM8914677","GSM8914676","GSM8914679","GSM8914678","GSM8914673","GSM8914672","GSM8914675","GSM8914674","GSM8914671","GSM8914670","GSM8914669","GSM8914666","GSM8914665","GSM8914668","GSM8914667","GSM8914662","GSM8914661","GSM8914664","GSM8914663","GSM8914660","GSM8915308","GSM8915307","GSM8915309","GSM8914699","GSM8915304","GSM8914698","GSM8915303","GSM8915306","GSM8915305","GSM8914695","GSM8915300","GSM8914694","GSM8915302","GSM8914697","GSM8914696","GSM8915301","GSM8914691","GSM8914690","GSM8914693","GSM8914692","GSM8914688","GSM8914687","GSM8914689","GSM8914684","GSM8914683","GSM8914686","GSM8914685","GSM8914680","GSM8914682","GSM8914681","GSM8914879","GSM8914637","GSM8914636","GSM8914878","GSM8914639","GSM8914638","GSM8914633","GSM8914875","GSM8914632","GSM8914874","GSM8914635","GSM8914877","GSM8914876","GSM8914634","GSM8914871","GSM8914870","GSM8914873","GSM8914631","GSM8914630","GSM8914872","GSM8914868","GSM8914626","GSM8914867","GSM8914625","GSM8914628","GSM8914627","GSM8914869","GSM8914864","GSM8914622","GSM8914621","GSM8914863","GSM8914624","GSM8914866","GSM8914865","GSM8914623","GSM8914629","GSM8914860","GSM8914862","GSM8914620","GSM8914861","GSM8914659","GSM8914658","GSM8914655","GSM8914897","GSM8914896","GSM8914654","GSM8914899","GSM8914657","GSM8914656","GSM8914898","GSM8914893","GSM8914651","GSM8914650","GSM8914892","GSM8914653","GSM8914895","GSM8914652","GSM8914894","GSM8914891","GSM8914890","GSM8914648","GSM8914647","GSM8914889","GSM8914649","GSM8914644","GSM8914886","GSM8914885","GSM8914643","GSM8914888","GSM8914646","GSM8914887","GSM8914645","GSM8914882","GSM8914640","GSM8914881","GSM8914884","GSM8914642","GSM8914641","GSM8914883","GSM8914880","GSM8914835","GSM8914834","GSM8914837","GSM8914836","GSM8914831","GSM8914830","GSM8914833","GSM8914832","GSM8914839","GSM8914838","GSM8914824","GSM8914823","GSM8914826","GSM8914825","GSM8914820","GSM8914822","GSM8914821","GSM8914828","GSM8914827","GSM8914829","GSM8914615","GSM8914857","GSM8914856","GSM8914614","GSM8914859","GSM8914617","GSM8914616","GSM8914858","GSM8914853","GSM8914611","GSM8914610","GSM8914852","GSM8914613","GSM8914855","GSM8914612","GSM8914854","GSM8914619","GSM8914618","GSM8914851","GSM8914850","GSM8914604","GSM8914846","GSM8914845","GSM8914603","GSM8914848","GSM8914606","GSM8914847","GSM8914605","GSM8914842","GSM8914600","GSM8914841","GSM8914844","GSM8914602","GSM8914601","GSM8914843","GSM8914608","GSM8914607","GSM8914849","GSM8914609","GSM8914840","GSM8914813","GSM8914812","GSM8914815","GSM8914814","GSM8914811","GSM8914810","GSM8914817","GSM8914816","GSM8914819","GSM8914818","GSM8914802","GSM8914801","GSM8914804","GSM8914803","GSM8914800","GSM8914809","GSM8914806","GSM8914805","GSM8914808","GSM8914807","GSM8915083","GSM8915082","GSM8915085","GSM8915084","GSM8915081","GSM8915080","GSM8915087","GSM8915086","GSM8915089","GSM8915088","GSM8915072","GSM8915071","GSM8915074","GSM8915073","GSM8915070","GSM8915079","GSM8915076","GSM8915075","GSM8915078","GSM8915077","GSM8915094","GSM8915093","GSM8915096","GSM8915095","GSM8915090","GSM8915092","GSM8915091","GSM8915098","GSM8915097","GSM8915099"],"GPL":["24247"],"GSE":["294665"],"taxon":["Mus musculus"]}}