{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294686/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294686"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part8]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294686","cross_references":{"GSM":["GSM8916139","GSM8916370","GSM8916372","GSM8916130","GSM8916371","GSM8916378","GSM8916136","GSM8916135","GSM8916377","GSM8916138","GSM8916379","GSM8916137","GSM8916132","GSM8916374","GSM8916373","GSM8916131","GSM8916376","GSM8916134","GSM8916375","GSM8916133","GSM8916129","GSM8916128","GSM8916361","GSM8916360","GSM8916367","GSM8916125","GSM8916124","GSM8916366","GSM8916369","GSM8916127","GSM8916126","GSM8916368","GSM8916121","GSM8916363","GSM8916120","GSM8916362","GSM8916123","GSM8916365","GSM8916364","GSM8916122","GSM8916392","GSM8916150","GSM8916391","GSM8916152","GSM8916394","GSM8916393","GSM8916151","GSM8916390","GSM8916158","GSM8916399","GSM8916157","GSM8916159","GSM8916396","GSM8916154","GSM8916395","GSM8916153","GSM8916398","GSM8916156","GSM8916155","GSM8916397","GSM8916381","GSM8916380","GSM8916141","GSM8916383","GSM8916140","GSM8916382","GSM8916147","GSM8916389","GSM8916146","GSM8916388","GSM8916149","GSM8916148","GSM8916143","GSM8916385","GSM8916384","GSM8916142","GSM8916387","GSM8916145","GSM8916144","GSM8916386","GSM8916338","GSM8916579","GSM8916337","GSM8916339","GSM8916570","GSM8916576","GSM8916334","GSM8916333","GSM8916575","GSM8916578","GSM8916336","GSM8916335","GSM8916577","GSM8916330","GSM8916572","GSM8916571","GSM8916332","GSM8916574","GSM8916573","GSM8916331","GSM8916327","GSM8916569","GSM8916568","GSM8916326","GSM8916329","GSM8916328","GSM8916565","GSM8916323","GSM8916564","GSM8916322","GSM8916567","GSM8916325","GSM8916324","GSM8916566","GSM8916561","GSM8916560","GSM8916321","GSM8916563","GSM8916562","GSM8916320","GSM8916118","GSM8916359","GSM8916117","GSM8916119","GSM8916590","GSM8916350","GSM8916592","GSM8916591","GSM8916598","GSM8916356","GSM8916114","GSM8916355","GSM8916113","GSM8916597","GSM8916358","GSM8916116","GSM8916115","GSM8916599","GSM8916357","GSM8916352","GSM8916594","GSM8916110","GSM8916593","GSM8916351","GSM8916112","GSM8916596","GSM8916354","GSM8916353","GSM8916111","GSM8916595","GSM8916349","GSM8916107","GSM8916106","GSM8916348","GSM8916109","GSM8916108","GSM8916581","GSM8916580","GSM8916103","GSM8916587","GSM8916345","GSM8916344","GSM8916102","GSM8916586","GSM8916347","GSM8916105","GSM8916589","GSM8916104","GSM8916588","GSM8916346","GSM8916341","GSM8916583","GSM8916582","GSM8916340","GSM8916585","GSM8916101","GSM8916343","GSM8916584","GSM8916100","GSM8916342","GSM8916539","GSM8916536","GSM8916778","GSM8916777","GSM8916535","GSM8916538","GSM8916779","GSM8916537","GSM8916774","GSM8916532","GSM8916773","GSM8916531","GSM8916776","GSM8916534","GSM8916533","GSM8916775","GSM8916770","GSM8916530","GSM8916772","GSM8916771","GSM8916529","GSM8916528","GSM8916767","GSM8916525","GSM8916524","GSM8916766","GSM8916527","GSM8916769","GSM8916768","GSM8916526","GSM8916521","GSM8916763","GSM8916762","GSM8916520","GSM8916765","GSM8916523","GSM8916764","GSM8916522","GSM8916761","GSM8916760","GSM8916319","GSM8916558","GSM8916316","GSM8916315","GSM8916799","GSM8916557","GSM8916318","GSM8916559","GSM8916317","GSM8916790","GSM8916312","GSM8916796","GSM8916554","GSM8916553","GSM8916311","GSM8916795","GSM8916556","GSM8916314","GSM8916798","GSM8916313","GSM8916797","GSM8916555","GSM8916550","GSM8916792","GSM8916791","GSM8916310","GSM8916794","GSM8916552","GSM8916793","GSM8916551","GSM8916309","GSM8916308","GSM8916547","GSM8916789","GSM8916305","GSM8916304","GSM8916788","GSM8916546","GSM8916307","GSM8916549","GSM8916548","GSM8916306","GSM8916301","GSM8916785","GSM8916543","GSM8916542","GSM8916300","GSM8916784","GSM8916787","GSM8916545","GSM8916303","GSM8916544","GSM8916302","GSM8916786","GSM8916781","GSM8916780","GSM8916541","GSM8916783","GSM8916782","GSM8916540","GSM8916738","GSM8916737","GSM8916739","GSM8916734","GSM8916733","GSM8916736","GSM8916735","GSM8916730","GSM8916732","GSM8916731","GSM8916727","GSM8916726","GSM8916729","GSM8916728","GSM8916723","GSM8916722","GSM8916725","GSM8916724","GSM8916721","GSM8916720","GSM8916518","GSM8916759","GSM8916517","GSM8916519","GSM8916756","GSM8916514","GSM8916513","GSM8916755","GSM8916516","GSM8916758","GSM8916515","GSM8916757","GSM8916510","GSM8916752","GSM8916751","GSM8916754","GSM8916512","GSM8916753","GSM8916511","GSM8916750","GSM8916507","GSM8916749","GSM8916748","GSM8916506","GSM8916509","GSM8916508","GSM8916745","GSM8916503","GSM8916744","GSM8916502","GSM8916747","GSM8916505","GSM8916504","GSM8916746","GSM8916741","GSM8916740","GSM8916501","GSM8916743","GSM8916742","GSM8916500","GSM8916925","GSM8916924","GSM8916927","GSM8916926","GSM8916921","GSM8916920","GSM8916923","GSM8916922","GSM8916929","GSM8916928","GSM8916716","GSM8916715","GSM8916718","GSM8916717","GSM8916712","GSM8916711","GSM8916714","GSM8916713","GSM8916719","GSM8916710","GSM8916705","GSM8916704","GSM8916707","GSM8916706","GSM8916701","GSM8916700","GSM8916703","GSM8916702","GSM8916709","GSM8916708","GSM8916914","GSM8916913","GSM8916916","GSM8916915","GSM8916910","GSM8916912","GSM8916911",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