{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294722/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294722"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of a human iPSC-derived blood-brain barrier-on-chip model of ischemic stroke","description":"Ischemic stroke is a leading cause of death and disability worldwide, characterized by reduced cerebral perfusion and blood-brain barrier (BBB) disruption. To model the human-specific pathophysiology of ischemic stroke, we developed a fully iPSC-derived blood-brain barrier-on-chip (iBBB-on-chip) comprising brain microvascular endothelial cells (iBMECs), pericytes (iPericytes), and astrocytes (iAstrocytes). After establishing a functional BBB structure, we induced ischemic injury by exposing the chip to oxygen-glucose deprivation (OGD) under static conditions. Transcriptome profiling of brain side ande endothelial side was performed to investigate molecular responses to ischemic stress.","dates":{"publication":"2026/04/15"},"accession":"GSE294722","cross_references":{"GSM":["GSM8917780","GSM8917778","GSM8917789","GSM8917779","GSM8917787","GSM8917788","GSM8917785","GSM8917786","GSM8917783","GSM8917784","GSM8917781","GSM8917782"],"GPL":["29480"],"GSE":["294722"],"taxon":["Homo sapiens"]}}