GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294722/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294722GEOGSEfalseTranscriptomic profiling of a human iPSC-derived blood-brain barrier-on-chip model of ischemic strokeIschemic stroke is a leading cause of death and disability worldwide, characterized by reduced cerebral perfusion and blood-brain barrier (BBB) disruption. To model the human-specific pathophysiology of ischemic stroke, we developed a fully iPSC-derived blood-brain barrier-on-chip (iBBB-on-chip) comprising brain microvascular endothelial cells (iBMECs), pericytes (iPericytes), and astrocytes (iAstrocytes). After establishing a functional BBB structure, we induced ischemic injury by exposing the chip to oxygen-glucose deprivation (OGD) under static conditions. Transcriptome profiling of brain side ande endothelial side was performed to investigate molecular responses to ischemic stress.2026/04/15GSE294722GSM8917780GSM8917778GSM8917789GSM8917779GSM8917787GSM8917788GSM8917785GSM8917786GSM8917783GSM8917784GSM8917781GSM891778229480294722Homo sapiens