GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294730/primaryOK200Other Mus musculusEscherichia coliOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294730GEOGSEfalseTumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancerThe impact of cancer driving mutations in regulating immunosurveillance throughout tumor development remains poorly understood. To better understand the contribution of tumor genotype to immunosurveillance, We generated and validated lentiviral vectors that establish an epi-allelic series of increasingly immunogenic neoantigens, integrating them with autochthonous Cre-regulated cancer models, CRISPR/Cas9-mediated somatic genome editing, and tumor barcoding into a single system. Using this sytem, we show that in the context of KRAS-driven lung cancer and strong neoantigen expression, tumor suppressor genotype dictates the degree of immune cell recruitment, positive selection of tumors with neoantigen silencing, and tumor outgrowth.2026/04/02GSE294730GSM8917949GSM8917969GSM8917947GSM8917948GSM8917945GSM8917967GSM8917968GSM8917946GSM8917965GSM8917943GSM8917966GSM8917944GSM8917963GSM8917941GSM8917942GSM8917964GSM8917961GSM8917962GSM8917960GSM8917958GSM8917959GSM8917956GSM8917957GSM8917954GSM8917955GSM8917974GSM8917952GSM8917975GSM8917953GSM8917972GSM8917950GSM8917951GSM8917973GSM8917970GSM89179712143324247294730 Mus musculusEscherichia coli