{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294777"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Early Intervention of the PKC-Hippo Signaling Alleviates Post-Traumatic Osteoarthritis","description":"Post-traumatic osteoarthritis (PTOA) is a progressive joint disease triggered by mechanical injury and characterized by inflammation and cartilage degradation. The Hippo signaling pathway and its upstream regulator PKCζ have emerged as key modulators of mechano-inflammatory responses in chondrocytes. This study aimed to investigate the dynamic regulation of the PKC-Hippo signaling axis following joint injury and to evaluate the therapeutic potential of targeting this pathway in early PTOA.","dates":{"publication":"2026/04/17"},"accession":"GSE294777","cross_references":{"GSM":["GSM8919385","GSM8919384","GSM8919383","GSM8919382","GSM8919381","GSM8919380","GSM8919379","GSM8919378","GSM8919377"],"GPL":["28457"],"GSE":["294777"],"taxon":["Mus musculus"]}}