{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294826/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294826"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part9]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294826","cross_references":{"GSM":["GSM8921970","GSM8921972","GSM8921971","GSM8921974","GSM8922822","GSM8921973","GSM8922823","GSM8922820","GSM8921976","GSM8922821","GSM8921975","GSM8921978","GSM8922826","GSM8922827","GSM8921977","GSM8922824","GSM8922825","GSM8921979","GSM8922828","GSM8922829","GSM8921981","GSM8922830","GSM8921980","GSM8921983","GSM8921982","GSM8922833","GSM8921985","GSM8922834","GSM8921984","GSM8922831","GSM8921987","GSM8921986","GSM8922832","GSM8921989","GSM8922837","GSM8921988","GSM8922838","GSM8922835","GSM8922836","GSM8922839","GSM8921950","GSM8921952","GSM8922800","GSM8921951","GSM8922801","GSM8921954","GSM8921953","GSM8922804","GSM8921956","GSM8922805","GSM8921955","GSM8922802","GSM8921958","GSM8921957","GSM8922803","GSM8922808","GSM8922809","GSM8921959","GSM8922806","GSM8922807","GSM8921961","GSM8921960","GSM8921963","GSM8922811","GSM8921962","GSM8922812","GSM8921965","GSM8922810","GSM8921964","GSM8921967","GSM8922815","GSM8921966","GSM8922816","GSM8921969","GSM8922813","GSM8921968","GSM8922814","GSM8922819","GSM8922817","GSM8922818","GSM8921930","GSM8921932","GSM8921931","GSM8921934","GSM8921933","GSM8921936","GSM8921935","GSM8921938","GSM8921937","GSM8921939","GSM8921941","GSM8921940","GSM8921943","GSM8921942","GSM8921945","GSM8921944","GSM8921947","GSM8921946","GSM8921949","GSM8921948","GSM8921909","GSM8921908","GSM8921910","GSM8921912","GSM8921911","GSM8921914","GSM8921913","GSM8921916","GSM8921915","GSM8921918","GSM8921917","GSM8921919","GSM8921921","GSM8921920","GSM8921923","GSM8921922","GSM8921925","GSM8921924","GSM8921927","GSM8921926","GSM8921929","GSM8921928","GSM8921901","GSM8921900","GSM8921903","GSM8921902","GSM8921905","GSM8921904","GSM8921907","GSM8921906","GSM8922180","GSM8922183","GSM8922184","GSM8922181","GSM8922182","GSM8922187","GSM8922188","GSM8922185","GSM8922186","GSM8922189","GSM8922190","GSM8922191","GSM8922194","GSM8922195","GSM8922192","GSM8922193","GSM8922198","GSM8922199","GSM8922196","GSM8922197","GSM8922161","GSM8922162","GSM8922160","GSM8922165","GSM8922166","GSM8922163","GSM8922164","GSM8922169","GSM8922167","GSM8922168","GSM8922172","GSM8922173","GSM8922170","GSM8922171","GSM8922176","GSM8922177","GSM8922174","GSM8922175","GSM8922178","GSM8922179","GSM8922381","GSM8922140","GSM8922382","GSM8922380","GSM8922143","GSM8922385","GSM8922386","GSM8922144","GSM8922383","GSM8922141","GSM8922384","GSM8922142","GSM8922389","GSM8922147","GSM8922148","GSM8922387","GSM8922145","GSM8922146","GSM8922388","GSM8922149","GSM8922392","GSM8922150","GSM8922393","GSM8922151","GSM8922390","GSM8922391","GSM8922154","GSM8922396","GSM8922155","GSM8922397","GSM8922152","GSM8922394","GSM8922395","GSM8922153","GSM8922158","GSM8922159","GSM8922398","GSM8922156","GSM8922157","GSM8922399","GSM8922360","GSM8922363","GSM8922121","GSM8922364","GSM8922122","GSM8922361","GSM8922120","GSM8922362","GSM8922367","GSM8922125","GSM8922126","GSM8922368","GSM8922123","GSM8922365","GSM8922366","GSM8922124","GSM8922129","GSM8922369","GSM8922127","GSM8922128","GSM8922370","GSM8922371","GSM8922132","GSM8922374","GSM8922375","GSM8922133","GSM8922372","GSM8922130","GSM8922131","GSM8922373","GSM8922378","GSM8922136","GSM8922137","GSM8922379","GSM8922134","GSM8922376","GSM8922135","GSM8922377","GSM8922138","GSM8922139","GSM8922580","GSM8922341","GSM8922583","GSM8922584","GSM8922100","GSM8922581","GSM8922340","GSM8922582","GSM8922103","GSM8922587","GSM8922346","GSM8922104","GSM8922588","GSM8922101","GSM8922585","GSM8922586","GSM8922102","GSM8922107","GSM8922108","GSM8922589","GSM8922105","GSM8922106","GSM8922109","GSM8922590","GSM8922591","GSM8922352","GSM8922110","GSM8922594","GSM8922595","GSM8922111","GSM8922353","GSM8922592","GSM8922350","GSM8922593","GSM8922114","GSM8922598","GSM8922356","GSM8922115","GSM8922599","GSM8922357","GSM8922112","GSM8922596","GSM8922354","GSM8922355","GSM8922113","GSM8922597","GSM8922118","GSM8922119","GSM8922358","GSM8922116","GSM8922117","GSM8922359","GSM8922561","GSM8922320","GSM8922562","GSM8922560","GSM8922323","GSM8922565","GSM8922324","GSM8922566","GSM8922321","GSM8922563","GSM8922564","GSM8922322","GSM8922569","GSM8922327","GSM8922328","GSM8922567","GSM8922325","GSM8922326","GSM8922568","GSM8922329","GSM8922572","GSM8922330","GSM8922573","GSM8922331","GSM8922570","GSM8922571","GSM8922576","GSM8922334","GSM8922335","GSM8922577","GSM8922332","GSM8922574","GSM8922575","GSM8922333","GSM8922338","GSM8922339","GSM8922578","GSM8922336","GSM8922579","GSM8922337","GSM8922782","GSM8922540","GSM8922301","GSM8922543","GSM8922544","GSM8922302","GSM8922541","GSM8922300","GSM8922542","GSM8922547","GSM8922789","GSM8922305","GSM8922306","GSM8922548","GSM8922303","GSM8922787","GSM8922545","GSM8922304","GSM8922788","GSM8922546","GSM8922309","GSM8922549","GSM8922307","GSM8922308","GSM8922550","GSM8922792","GSM8922793","GSM8922551","GSM8922790","GSM8922791","GSM8922796","GSM8922312","GSM8922554","GSM8922555","GSM8922313",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