{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294832/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294832"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294832","cross_references":{"GSM":["GSM8923092","GSM8923093","GSM8923090","GSM8923091","GSM8923096","GSM8923097","GSM8923094","GSM8923095","GSM8923098","GSM8923099","GSM8923070","GSM8923071","GSM8923074","GSM8923075","GSM8923072","GSM8923073","GSM8923078","GSM8923079","GSM8923076","GSM8923077","GSM8923081","GSM8923082","GSM8923080","GSM8923085","GSM8923086","GSM8923083","GSM8923084","GSM8923089","GSM8923087","GSM8923088","GSM8923290","GSM8923291","GSM8923052","GSM8923294","GSM8923295","GSM8923053","GSM8923292","GSM8923050","GSM8923293","GSM8923051","GSM8923298","GSM8923056","GSM8923299","GSM8923057","GSM8923296","GSM8923054","GSM8923055","GSM8923297","GSM8923058","GSM8923059","GSM8923060","GSM8923063","GSM8923064","GSM8923061","GSM8923062","GSM8923067","GSM8923068","GSM8923065","GSM8923066","GSM8923069","GSM8923272","GSM8923030","GSM8923273","GSM8923031","GSM8923270","GSM8923271","GSM8923276","GSM8923034","GSM8923035","GSM8923277","GSM8923032","GSM8923274","GSM8923275","GSM8923033","GSM8923038","GSM8923039","GSM8923278","GSM8923036","GSM8923279","GSM8923037","GSM8923280","GSM8923041","GSM8923283","GSM8923284","GSM8923042","GSM8923281","GSM8923040","GSM8923282","GSM8923287","GSM8923045","GSM8923046","GSM8923288","GSM8923043","GSM8923285","GSM8923044","GSM8923286","GSM8923049","GSM8923289","GSM8923047","GSM8923048","GSM8923250","GSM8923492","GSM8923493","GSM8923251","GSM8923490","GSM8923491","GSM8923012","GSM8923496","GSM8923254","GSM8923255","GSM8923013","GSM8923497","GSM8923252","GSM8923010","GSM8923494","GSM8923253","GSM8923495","GSM8923011","GSM8923258","GSM8923016","GSM8923259","GSM8923017","GSM8923498","GSM8923256","GSM8923014","GSM8923015","GSM8923499","GSM8923257","GSM8923018","GSM8923019","GSM8923261","GSM8923020","GSM8923262","GSM8923260","GSM8923023","GSM8923265","GSM8923024","GSM8923266","GSM8923021","GSM8923263","GSM8923264","GSM8923022","GSM8923269","GSM8923027","GSM8923028","GSM8923267","GSM8923025","GSM8923026","GSM8923268","GSM8923029","GSM8923470","GSM8923471","GSM8923232","GSM8923474","GSM8923475","GSM8923233","GSM8923230","GSM8923472","GSM8923473","GSM8923231","GSM8923478","GSM8923236","GSM8923479","GSM8923237","GSM8923476","GSM8923234","GSM8923235","GSM8923477","GSM8923238","GSM8923239","GSM8923481","GSM8923482","GSM8923240","GSM8923480","GSM8923001","GSM8923485","GSM8923243","GSM8923244","GSM8923002","GSM8923486","GSM8923241","GSM8923483","GSM8923000","GSM8923484","GSM8923242","GSM8923247","GSM8923489","GSM8923005","GSM8923006","GSM8923248","GSM8923003","GSM8923487","GSM8923245","GSM8923004","GSM8923488","GSM8923246","GSM8923009","GSM8923249","GSM8923007","GSM8923008","GSM8923690","GSM8923691","GSM8923210","GSM8923694","GSM8923452","GSM8923453","GSM8923211","GSM8923695","GSM8923450","GSM8923692","GSM8923693","GSM8923451","GSM8923456","GSM8923214","GSM8923698","GSM8923215","GSM8923699","GSM8923457","GSM8923212","GSM8923696","GSM8923454","GSM8923455","GSM8923213","GSM8923697","GSM8923218","GSM8923219","GSM8923458","GSM8923216","GSM8923459","GSM8923217","GSM8923460","GSM8923221","GSM8923463","GSM8923464","GSM8923222","GSM8923461","GSM8923462","GSM8923220","GSM8923467","GSM8923225","GSM8923226","GSM8923468","GSM8923465","GSM8923223","GSM8923224","GSM8923466","GSM8923229","GSM8923227","GSM8923469","GSM8923228","GSM8923430","GSM8923672","GSM8923673","GSM8923431","GSM8923670","GSM8923671","GSM8923676","GSM8923434","GSM8923435","GSM8923677","GSM8923674","GSM8923432","GSM8923433","GSM8923675","GSM8923438","GSM8923439","GSM8923436","GSM8923678","GSM8923679","GSM8923437","GSM8923680","GSM8923441","GSM8923683","GSM8923684","GSM8923442","GSM8923200","GSM8923681","GSM8923682","GSM8923440","GSM8923687","GSM8923445","GSM8923203","GSM8923204","GSM8923688","GSM8923446","GSM8923685","GSM8923201","GSM8923443","GSM8923444","GSM8923202","GSM8923686","GSM8923207","GSM8923449","GSM8923208","GSM8923447","GSM8923205","GSM8923689","GSM8923206","GSM8923448","GSM8923209","GSM8923650","GSM8923651","GSM8923654","GSM8923412","GSM8923413","GSM8923655","GSM8923410","GSM8923652","GSM8923653","GSM8923411","GSM8923416","GSM8923658","GSM8923659","GSM8923417","GSM8923656","GSM8923414","GSM8923415","GSM8923657","GSM8923418","GSM8923419","GSM8923661","GSM8923662","GSM8923420","GSM8923660","GSM8923665","GSM8923423","GSM8923424","GSM8923666","GSM8923421","GSM8923663","GSM8923664","GSM8923422","GSM8923427","GSM8923669","GSM8923428","GSM8923667","GSM8923425","GSM8923668","GSM8923426","GSM8923429","GSM8923870","GSM8923871","GSM8923874","GSM8923632","GSM8923633","GSM8923875","GSM8923630","GSM8923872","GSM8923873","GSM8923631","GSM8923636","GSM8923878","GSM8923879","GSM8923637","GSM8923876","GSM8923634","GSM8923877","GSM8923635","GSM8923638","GSM8923639","GSM8923881","GSM8923882","GSM8923640","GSM8923880","GSM8923401","GSM8923885","GSM8923643","GSM8923644","GSM8923886","GSM8923402","GSM8923883","GSM8923641","GSM8923642","GSM8923884","GSM8923400","GSM8923647","GSM8923405",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