{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294836/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294836"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice[part11]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294836","cross_references":{"GSM":["GSM8923911","GSM8923912","GSM8923910","GSM8923915","GSM8923916","GSM8923913","GSM8923914","GSM8923919","GSM8923917","GSM8923918","GSM8923922","GSM8923923","GSM8923920","GSM8923921","GSM8923926","GSM8923927","GSM8923924","GSM8923925","GSM8923928","GSM8923929","GSM8923900","GSM8923901","GSM8923904","GSM8923905","GSM8923902","GSM8923903","GSM8923908","GSM8923909","GSM8923906","GSM8923907","GSM8924182","GSM8924181","GSM8924180","GSM8924186","GSM8924185","GSM8924184","GSM8924183","GSM8924189","GSM8924188","GSM8924187","GSM8924193","GSM8924192","GSM8924191","GSM8924190","GSM8924197","GSM8924196","GSM8924195","GSM8924194","GSM8924199","GSM8924198","GSM8924160","GSM8924164","GSM8924163","GSM8924162","GSM8924161","GSM8924168","GSM8924167","GSM8924166","GSM8924165","GSM8924169","GSM8924171","GSM8924170","GSM8924175","GSM8924174","GSM8924173","GSM8924172","GSM8924179","GSM8924178","GSM8924177","GSM8924176","GSM8924380","GSM8924142","GSM8924384","GSM8924383","GSM8924141","GSM8924382","GSM8924140","GSM8924381","GSM8924388","GSM8924146","GSM8924145","GSM8924387","GSM8924144","GSM8924386","GSM8924385","GSM8924143","GSM8924149","GSM8924148","GSM8924147","GSM8924389","GSM8924391","GSM8924390","GSM8924153","GSM8924395","GSM8924394","GSM8924152","GSM8924393","GSM8924151","GSM8924150","GSM8924392","GSM8924399","GSM8924157","GSM8924156","GSM8924398","GSM8924397","GSM8924155","GSM8924396","GSM8924154","GSM8924159","GSM8924158","GSM8924362","GSM8924120","GSM8924361","GSM8924360","GSM8924124","GSM8924366","GSM8924365","GSM8924123","GSM8924122","GSM8924364","GSM8924363","GSM8924121","GSM8924128","GSM8924127","GSM8924369","GSM8924368","GSM8924126","GSM8924125","GSM8924367","GSM8924129","GSM8924373","GSM8924131","GSM8924130","GSM8924372","GSM8924371","GSM8924370","GSM8924377","GSM8924135","GSM8924376","GSM8924134","GSM8924133","GSM8924375","GSM8924374","GSM8924132","GSM8924139","GSM8924138","GSM8924379","GSM8924137","GSM8924136","GSM8924378","GSM8924582","GSM8924340","GSM8924581","GSM8924580","GSM8924102","GSM8924586","GSM8924344","GSM8924101","GSM8924585","GSM8924343","GSM8924342","GSM8924100","GSM8924584","GSM8924583","GSM8924341","GSM8924348","GSM8924106","GSM8924589","GSM8924105","GSM8924347","GSM8924104","GSM8924588","GSM8924346","GSM8924345","GSM8924587","GSM8924103","GSM8924109","GSM8924108","GSM8924107","GSM8924349","GSM8924351","GSM8924593","GSM8924592","GSM8924350","GSM8924591","GSM8924590","GSM8924113","GSM8924597","GSM8924355","GSM8924354","GSM8924112","GSM8924596","GSM8924353","GSM8924111","GSM8924595","GSM8924110","GSM8924594","GSM8924352","GSM8924359","GSM8924117","GSM8924116","GSM8924358","GSM8924357","GSM8924599","GSM8924115","GSM8924356","GSM8924114","GSM8924598","GSM8924119","GSM8924118","GSM8924560","GSM8924322","GSM8924564","GSM8924563","GSM8924321","GSM8924562","GSM8924320","GSM8924561","GSM8924568","GSM8924326","GSM8924325","GSM8924567","GSM8924566","GSM8924324","GSM8924565","GSM8924323","GSM8924329","GSM8924328","GSM8924569","GSM8924327","GSM8924571","GSM8924570","GSM8924333","GSM8924575","GSM8924574","GSM8924332","GSM8924331","GSM8924573","GSM8924330","GSM8924572","GSM8924337","GSM8924579","GSM8924336","GSM8924578","GSM8924577","GSM8924335","GSM8924334","GSM8924576","GSM8924339","GSM8924338","GSM8924780","GSM8924542","GSM8924300","GSM8924541","GSM8924540","GSM8924546","GSM8924304","GSM8924545","GSM8924303","GSM8924302","GSM8924786","GSM8924544","GSM8924543","GSM8924301","GSM8924308","GSM8924549","GSM8924307","GSM8924548","GSM8924306","GSM8924305","GSM8924547","GSM8924309","GSM8924311","GSM8924795","GSM8924553","GSM8924310","GSM8924794","GSM8924552","GSM8924551","GSM8924550","GSM8924557","GSM8924799","GSM8924315","GSM8924314","GSM8924798","GSM8924556","GSM8924313","GSM8924797","GSM8924555","GSM8924554","GSM8924312","GSM8924796","GSM8924319","GSM8924318","GSM8924559","GSM8924317","GSM8924316","GSM8924558","GSM8924520","GSM8924762","GSM8924761","GSM8924760","GSM8924766","GSM8924524","GSM8924523","GSM8924765","GSM8924522","GSM8924764","GSM8924763","GSM8924521","GSM8924528","GSM8924769","GSM8924527","GSM8924768","GSM8924526","GSM8924525","GSM8924767","GSM8924529","GSM8924531","GSM8924773","GSM8924772","GSM8924530","GSM8924771","GSM8924770","GSM8924777","GSM8924535","GSM8924534","GSM8924776","GSM8924775","GSM8924533","GSM8924774","GSM8924532","GSM8924539","GSM8924538","GSM8924537","GSM8924779","GSM8924778","GSM8924536","GSM8924740","GSM8923893","GSM8924502","GSM8923896","GSM8924744","GSM8924743","GSM8923897","GSM8924501","GSM8924500","GSM8923894","GSM8924742","GSM8923895","GSM8924741","GSM8924748","GSM8924506","GSM8924505","GSM8924747","GSM8923898","GSM8924746","GSM8924504","GSM8923899","GSM8924503","GSM8924745","GSM8924509","GSM8924508","GSM8924749","GSM8924507","GSM8924751","GSM8924750","GSM8924755","GSM8924513","GSM8924754","GSM8924512","GSM8924511","GSM8924753","GSM8924752","GSM8924510","GSM8924517","GSM8924759",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