{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294845"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part12]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294845","cross_references":{"GSM":["GSM8925091","GSM8925090","GSM8925095","GSM8925094","GSM8925093","GSM8925092","GSM8925099","GSM8925098","GSM8925097","GSM8925096","GSM8925073","GSM8925072","GSM8925071","GSM8925070","GSM8925077","GSM8925076","GSM8925075","GSM8925074","GSM8925079","GSM8925078","GSM8925080","GSM8925084","GSM8925083","GSM8925082","GSM8925081","GSM8925088","GSM8925087","GSM8925086","GSM8925085","GSM8925089","GSM8925051","GSM8925293","GSM8925292","GSM8925050","GSM8925291","GSM8925290","GSM8925297","GSM8925055","GSM8925054","GSM8925296","GSM8925295","GSM8925053","GSM8925052","GSM8925294","GSM8925059","GSM8925058","GSM8925057","GSM8925299","GSM8925298","GSM8925056","GSM8925062","GSM8925061","GSM8925060","GSM8925066","GSM8925065","GSM8925064","GSM8925063","GSM8925069","GSM8925068","GSM8925067","GSM8925271","GSM8925270","GSM8925275","GSM8925033","GSM8925274","GSM8925032","GSM8925031","GSM8925273","GSM8925272","GSM8925030","GSM8925037","GSM8925279","GSM8925278","GSM8925036","GSM8925277","GSM8925035","GSM8925034","GSM8925276","GSM8925039","GSM8925038","GSM8925040","GSM8925282","GSM8925281","GSM8925280","GSM8925286","GSM8925044","GSM8925043","GSM8925285","GSM8925284","GSM8925042","GSM8925283","GSM8925041","GSM8925048","GSM8925289","GSM8925047","GSM8925046","GSM8925288","GSM8925045","GSM8925287","GSM8925049","GSM8925491","GSM8925490","GSM8925495","GSM8925011","GSM8925253","GSM8925252","GSM8925494","GSM8925010","GSM8925493","GSM8925251","GSM8925492","GSM8925250","GSM8925257","GSM8925015","GSM8925499","GSM8925014","GSM8925498","GSM8925256","GSM8925255","GSM8925013","GSM8925497","GSM8925254","GSM8925012","GSM8925496","GSM8925019","GSM8925018","GSM8925017","GSM8925259","GSM8925258","GSM8925016","GSM8925260","GSM8925264","GSM8925022","GSM8925263","GSM8925021","GSM8925020","GSM8925262","GSM8925261","GSM8925026","GSM8925268","GSM8925025","GSM8925267","GSM8925266","GSM8925024","GSM8925023","GSM8925265","GSM8925029","GSM8925028","GSM8925269","GSM8925027","GSM8925473","GSM8925231","GSM8925472","GSM8925230","GSM8925471","GSM8925470","GSM8925235","GSM8925477","GSM8925234","GSM8925476","GSM8925475","GSM8925233","GSM8925232","GSM8925474","GSM8925239","GSM8925238","GSM8925237","GSM8925479","GSM8925478","GSM8925236","GSM8925480","GSM8925484","GSM8925000","GSM8925242","GSM8925483","GSM8925241","GSM8925240","GSM8925482","GSM8925481","GSM8925246","GSM8925004","GSM8925488","GSM8925003","GSM8925487","GSM8925245","GSM8925486","GSM8925244","GSM8925002","GSM8925243","GSM8925485","GSM8925001","GSM8925008","GSM8925249","GSM8925007","GSM8925006","GSM8925248","GSM8925005","GSM8925489","GSM8925247","GSM8925009","GSM8925693","GSM8925451","GSM8925692","GSM8925450","GSM8925691","GSM8925690","GSM8925455","GSM8925213","GSM8925697","GSM8925212","GSM8925696","GSM8925454","GSM8925695","GSM8925453","GSM8925211","GSM8925452","GSM8925210","GSM8925694","GSM8925459","GSM8925458","GSM8925699","GSM8925215","GSM8925457","GSM8925214","GSM8925698","GSM8925456","GSM8925220","GSM8925462","GSM8925461","GSM8925460","GSM8925466","GSM8925224","GSM8925223","GSM8925465","GSM8925464","GSM8925222","GSM8925463","GSM8925228","GSM8925469","GSM8925227","GSM8925226","GSM8925468","GSM8925467","GSM8925225","GSM8925229","GSM8925671","GSM8925670","GSM8925675","GSM8925433","GSM8925432","GSM8925674","GSM8925673","GSM8925431","GSM8925672","GSM8925430","GSM8925679","GSM8925437","GSM8925678","GSM8925436","GSM8925435","GSM8925677","GSM8925676","GSM8925434","GSM8925439","GSM8925438","GSM8925682","GSM8925440","GSM8925681","GSM8925680","GSM8925444","GSM8925202","GSM8925686","GSM8925443","GSM8925201","GSM8925685","GSM8925200","GSM8925684","GSM8925442","GSM8925441","GSM8925683","GSM8925206","GSM8925448","GSM8925447","GSM8925689","GSM8925205","GSM8925446","GSM8925204","GSM8925688","GSM8925203","GSM8925687","GSM8925445","GSM8925209","GSM8925208","GSM8925449","GSM8925207","GSM8925891","GSM8925890","GSM8925653","GSM8925411","GSM8925895","GSM8925652","GSM8925410","GSM8925894","GSM8925893","GSM8925651","GSM8925650","GSM8925892","GSM8925899","GSM8925415","GSM8925657","GSM8925898","GSM8925656","GSM8925414","GSM8925655","GSM8925413","GSM8925897","GSM8925412","GSM8925896","GSM8925654","GSM8925419","GSM8925418","GSM8925659","GSM8925417","GSM8925658","GSM8925416","GSM8925660","GSM8925664","GSM8925422","GSM8925421","GSM8925663","GSM8925420","GSM8925662","GSM8925661","GSM8925426","GSM8925668","GSM8925667","GSM8925425","GSM8925424","GSM8925666","GSM8925423","GSM8925665","GSM8925429","GSM8925428","GSM8925669","GSM8925427","GSM8925873","GSM8925631","GSM8925630","GSM8925872","GSM8925871","GSM8925870","GSM8925635","GSM8925877","GSM8925876","GSM8925634","GSM8925633","GSM8925875","GSM8925632","GSM8925874","GSM8925639","GSM8925638","GSM8925879","GSM8925637","GSM8925878","GSM8925636","GSM8925880","GSM8925400","GSM8925884","GSM8925642","GSM8925641","GSM8925883","GSM8925882","GSM8925640","GSM8925881","GSM8925404","GSM8925888","GSM8925646",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