{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294849/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294849"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part13]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294849","cross_references":{"GSM":["GSM8926180","GSM8926184","GSM8926183","GSM8926182","GSM8926181","GSM8926188","GSM8926187","GSM8926186","GSM8926185","GSM8926189","GSM8926191","GSM8926190","GSM8926195","GSM8926194","GSM8926193","GSM8926192","GSM8926199","GSM8926198","GSM8926197","GSM8926196","GSM8926162","GSM8926161","GSM8926160","GSM8927014","GSM8926166","GSM8927015","GSM8926165","GSM8926164","GSM8927016","GSM8927017","GSM8926163","GSM8927010","GSM8927011","GSM8926169","GSM8927012","GSM8926168","GSM8926167","GSM8927013","GSM8927018","GSM8927019","GSM8927020","GSM8926173","GSM8926172","GSM8926171","GSM8926170","GSM8926177","GSM8926176","GSM8926175","GSM8926174","GSM8927021","GSM8927022","GSM8926179","GSM8926178","GSM8926382","GSM8926140","GSM8926381","GSM8926380","GSM8926144","GSM8926386","GSM8926385","GSM8926143","GSM8926384","GSM8926142","GSM8926141","GSM8926383","GSM8926148","GSM8926147","GSM8926389","GSM8926388","GSM8926146","GSM8926387","GSM8926145","GSM8926149","GSM8926393","GSM8926151","GSM8926150","GSM8926392","GSM8926391","GSM8926390","GSM8926155","GSM8927003","GSM8926397","GSM8926396","GSM8927004","GSM8926154","GSM8927005","GSM8926153","GSM8926395","GSM8926152","GSM8927006","GSM8926394","GSM8926159","GSM8926158","GSM8927000","GSM8926399","GSM8927001","GSM8926157","GSM8927002","GSM8926156","GSM8926398","GSM8927007","GSM8927008","GSM8927009","GSM8926360","GSM8926364","GSM8926122","GSM8926121","GSM8926363","GSM8926362","GSM8926120","GSM8926361","GSM8926368","GSM8926126","GSM8926367","GSM8926125","GSM8926124","GSM8926366","GSM8926365","GSM8926123","GSM8926129","GSM8926128","GSM8926127","GSM8926369","GSM8926371","GSM8926370","GSM8926133","GSM8926375","GSM8926132","GSM8926374","GSM8926373","GSM8926131","GSM8926130","GSM8926372","GSM8926379","GSM8926137","GSM8926378","GSM8926136","GSM8926135","GSM8926377","GSM8926376","GSM8926134","GSM8926139","GSM8926138","GSM8926580","GSM8926342","GSM8926100","GSM8926584","GSM8926341","GSM8926583","GSM8926582","GSM8926340","GSM8926581","GSM8926588","GSM8926104","GSM8926346","GSM8926587","GSM8926345","GSM8926103","GSM8926344","GSM8926102","GSM8926586","GSM8926101","GSM8926585","GSM8926343","GSM8926108","GSM8926107","GSM8926349","GSM8926348","GSM8926106","GSM8926347","GSM8926105","GSM8926589","GSM8926109","GSM8926591","GSM8926590","GSM8926353","GSM8926111","GSM8926595","GSM8926594","GSM8926110","GSM8926352","GSM8926593","GSM8926351","GSM8926350","GSM8926592","GSM8926599","GSM8926115","GSM8926357","GSM8926356","GSM8926598","GSM8926114","GSM8926597","GSM8926113","GSM8926355","GSM8926112","GSM8926596","GSM8926354","GSM8926119","GSM8926118","GSM8926359","GSM8926117","GSM8926358","GSM8926116","GSM8926562","GSM8926320","GSM8926561","GSM8926560","GSM8926324","GSM8926566","GSM8926565","GSM8926323","GSM8926322","GSM8926564","GSM8926321","GSM8926563","GSM8926328","GSM8926327","GSM8926569","GSM8926568","GSM8926326","GSM8926567","GSM8926325","GSM8926329","GSM8926573","GSM8926331","GSM8926330","GSM8926572","GSM8926571","GSM8926570","GSM8926577","GSM8926335","GSM8926576","GSM8926334","GSM8926333","GSM8926575","GSM8926574","GSM8926332","GSM8926339","GSM8926338","GSM8926579","GSM8926337","GSM8926336","GSM8926578","GSM8926783","GSM8926540","GSM8926784","GSM8926785","GSM8926786","GSM8926302","GSM8926544","GSM8926301","GSM8926780","GSM8926543","GSM8926542","GSM8926781","GSM8926300","GSM8926782","GSM8926541","GSM8926548","GSM8926306","GSM8926547","GSM8926305","GSM8926304","GSM8926546","GSM8926545","GSM8926303","GSM8926787","GSM8926788","GSM8926309","GSM8926789","GSM8926308","GSM8926307","GSM8926549","GSM8926794","GSM8926551","GSM8926550","GSM8926795","GSM8926796","GSM8926797","GSM8926313","GSM8926555","GSM8926790","GSM8926791","GSM8926554","GSM8926312","GSM8926553","GSM8926311","GSM8926792","GSM8926310","GSM8926552","GSM8926793","GSM8926559","GSM8926317","GSM8926316","GSM8926558","GSM8926557","GSM8926315","GSM8926556","GSM8926314","GSM8926798","GSM8926799","GSM8926319","GSM8926318","GSM8926761","GSM8926762","GSM8926763","GSM8926764","GSM8926522","GSM8926521","GSM8926520","GSM8926760","GSM8926526","GSM8926769","GSM8926525","GSM8926524","GSM8926523","GSM8926765","GSM8926766","GSM8926529","GSM8926528","GSM8926767","GSM8926527","GSM8926768","GSM8926772","GSM8926773","GSM8926774","GSM8926775","GSM8926533","GSM8926532","GSM8926531","GSM8926770","GSM8926530","GSM8926771","GSM8926537","GSM8926536","GSM8926535","GSM8926534","GSM8926776","GSM8926777","GSM8926539","GSM8926778","GSM8926779","GSM8926538","GSM8926981","GSM8926982","GSM8926740","GSM8926983","GSM8926741","GSM8926742","GSM8926984","GSM8926500","GSM8926980","GSM8926504","GSM8926989","GSM8926747","GSM8926748","GSM8926503","GSM8926502","GSM8926749","GSM8926501","GSM8926985","GSM8926508","GSM8926743","GSM8926507","GSM8926986","GSM8926744","GSM8926745","GSM8926506","GSM8926987","GSM8926988","GSM8926505","GSM8926746","GSM8926509","GSM8926992","GSM8926750","GSM8926751","GSM8926993",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