GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294864/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294864GEOGSEfalseEngineered cytokine-secreting cells to prevent foreign body response against implantsForeign body response hinders the long-term functionality of implants such as microencapsulated cell therapies. To address this issue, we delivered encapsulated engineered cells that secrete targeted cytokines to mitigate fibrosis on microcapsules. Here, we quantify immune profile change due to these encapsulated cytokine-secreting cells in mice. We identified that IL10 prevents inflammatory response while IL12 impairs the TGF-beta pathway to mitigate fibrosis.2026/04/06GSE294864GSM8927234GSM8927235GSM8927236GSM8927237GSM8927231GSM8927232GSM892723324247294864Mus musculus