{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294892"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Impaired taurine transport contributes to the development of bronchopulmonary dysplasia","description":"Sprague-Dawley rat pups were used to study the effect of taurine supplementation on hyperoxia-exposed lungs. The study, which was conducted with meticulous attention to detail, found significant effects of taurine supplementation. Rat pups were randomly assigned to room air (NOX) and >90% oxygen (HOX) from postnatal day 1 (P1) to P10. Half of the pups of each group received a daily taurine (100 mg/kg) intraperitoneal injection or an equal volume of PBS (two by two design). The four groups were NOX-PBS, NOX-taurine, HOX-PBS, and HOX-taurine. At P10, a comprehensive range of methodologies was employed, including morphometrics, histology, metabolomics, and immunoblots. Two pups, one male and one female, were randomly selected for single-cell RNA sequencing at P10","dates":{"publication":"2026/04/15"},"accession":"GSE294892","cross_references":{"GSM":["GSM8927784","GSM8927781","GSM8927782","GSM8927783"],"GPL":["20084"],"GSE":["294892"],"taxon":["Rattus norvegicus"]}}