{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294911/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294911"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294911","cross_references":{"GSM":["GSM8928360","GSM8928361","GSM8928362","GSM8928367","GSM8928368","GSM8928369","GSM8928363","GSM8928364","GSM8928365","GSM8928366","GSM8928370","GSM8928371","GSM8928372","GSM8928373","GSM8928378","GSM8928379","GSM8928374","GSM8928375","GSM8928376","GSM8928377","GSM8928580","GSM8928581","GSM8928340","GSM8928582","GSM8928345","GSM8928587","GSM8928346","GSM8928588","GSM8928589","GSM8928347","GSM8928348","GSM8928583","GSM8928341","GSM8928342","GSM8928584","GSM8928343","GSM8928585","GSM8928586","GSM8928344","GSM8928349","GSM8928590","GSM8928591","GSM8928592","GSM8928350","GSM8928351","GSM8928593","GSM8928598","GSM8928356","GSM8928357","GSM8928599","GSM8928358","GSM8928359","GSM8928594","GSM8928352","GSM8928595","GSM8928353","GSM8928354","GSM8928596","GSM8928597","GSM8928355","GSM8928560","GSM8928323","GSM8928565","GSM8928566","GSM8928324","GSM8928325","GSM8928567","GSM8928326","GSM8928568","GSM8928561","GSM8928320","GSM8928562","GSM8928563","GSM8928321","GSM8928322","GSM8928564","GSM8928569","GSM8928327","GSM8928328","GSM8928329","GSM8928570","GSM8928571","GSM8928334","GSM8928576","GSM8928577","GSM8928335","GSM8928578","GSM8928336","GSM8928337","GSM8928579","GSM8928572","GSM8928330","GSM8928331","GSM8928573","GSM8928574","GSM8928332","GSM8928575","GSM8928333","GSM8928338","GSM8928339","GSM8928543","GSM8928301","GSM8928302","GSM8928544","GSM8928303","GSM8928545","GSM8928546","GSM8928304","GSM8928540","GSM8928541","GSM8928300","GSM8928784","GSM8928542","GSM8928309","GSM8928305","GSM8928789","GSM8928547","GSM8928306","GSM8928548","GSM8928549","GSM8928307","GSM8928308","GSM8928790","GSM8928791","GSM8928554","GSM8928312","GSM8928796","GSM8928555","GSM8928797","GSM8928313","GSM8928314","GSM8928798","GSM8928556","GSM8928557","GSM8928315","GSM8928799","GSM8928792","GSM8928550","GSM8928551","GSM8928793","GSM8928552","GSM8928310","GSM8928794","GSM8928311","GSM8928795","GSM8928553","GSM8928558","GSM8928316","GSM8928317","GSM8928559","GSM8928318","GSM8928319","GSM8928763","GSM8928521","GSM8928522","GSM8928523","GSM8928524","GSM8928760","GSM8928520","GSM8928529","GSM8928525","GSM8928526","GSM8928768","GSM8928527","GSM8928528","GSM8928532","GSM8928533","GSM8928534","GSM8928535","GSM8928530","GSM8928531","GSM8928773","GSM8928778","GSM8928536","GSM8928537","GSM8928538","GSM8928539","GSM8928741","GSM8928983","GSM8928500","GSM8928984","GSM8928742","GSM8928743","GSM8928501","GSM8928985","GSM8928744","GSM8928502","GSM8928986","GSM8928980","GSM8928981","GSM8928740","GSM8928982","GSM8928749","GSM8928507","GSM8928508","GSM8928509","GSM8928503","GSM8928987","GSM8928745","GSM8928746","GSM8928504","GSM8928988","GSM8928989","GSM8928747","GSM8928505","GSM8928506","GSM8928748","GSM8928752","GSM8928510","GSM8928994","GSM8928511","GSM8928995","GSM8928753","GSM8928512","GSM8928996","GSM8928754","GSM8928755","GSM8928513","GSM8928997","GSM8928990","GSM8928991","GSM8928992","GSM8928750","GSM8928993","GSM8928751","GSM8928518","GSM8928519","GSM8928514","GSM8928998","GSM8928756","GSM8928515","GSM8928999","GSM8928757","GSM8928758","GSM8928516","GSM8928517","GSM8928759","GSM8928961","GSM8928720","GSM8928962","GSM8928721","GSM8928963","GSM8928964","GSM8928722","GSM8928960","GSM8928969","GSM8928727","GSM8928728","GSM8928729","GSM8928723","GSM8928965","GSM8928966","GSM8928724","GSM8928967","GSM8928725","GSM8928726","GSM8928968","GSM8928972","GSM8928730","GSM8928973","GSM8928731","GSM8928732","GSM8928974","GSM8928975","GSM8928733","GSM8928970","GSM8928971","GSM8928738","GSM8928739","GSM8928976","GSM8928734","GSM8928735","GSM8928977","GSM8928978","GSM8928736","GSM8928737","GSM8928979","GSM8928940","GSM8928941","GSM8928700","GSM8928942","GSM8928947","GSM8928705","GSM8928706","GSM8928948","GSM8928949","GSM8928707","GSM8928708","GSM8928701","GSM8928943","GSM8928944","GSM8928702","GSM8928703","GSM8928945","GSM8928946","GSM8928704","GSM8928709","GSM8928950","GSM8928951","GSM8928952","GSM8928710","GSM8928953","GSM8928711","GSM8928958","GSM8928716","GSM8928717","GSM8928959","GSM8928718","GSM8928719","GSM8928712","GSM8928954","GSM8928955","GSM8928713","GSM8928956","GSM8928714","GSM8928715","GSM8928957","GSM8928920","GSM8928925","GSM8928926","GSM8928927","GSM8928928","GSM8928921","GSM8928922","GSM8928923","GSM8928924","GSM8928929","GSM8928930","GSM8928931","GSM8928936","GSM8928937","GSM8928938","GSM8928939","GSM8928932","GSM8928933","GSM8928934","GSM8928935","GSM8928903","GSM8928904","GSM8928905","GSM8928906","GSM8928900","GSM8928901","GSM8928902","GSM8928907","GSM8928908","GSM8928909","GSM8928914","GSM8928915","GSM8928916","GSM8928917","GSM8928910","GSM8928911","GSM8928912","GSM8928913","GSM8928918","GSM8928919","GSM8929174","GSM8929173","GSM8929176","GSM8929175","GSM8929170","GSM8929172","GSM8929171","GSM8929178","GSM8929177","GSM8929179","GSM8929185","GSM8929184","GSM8929186","GSM8929181","GSM8929180","GSM8929183","GSM8929182","GSM8929152","GSM8929151","GSM8929154",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