{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294926/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294926"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part15]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294926","cross_references":{"GSM":["GSM8929691","GSM8929690","GSM8929693","GSM8929692","GSM8929699","GSM8929457","GSM8929698","GSM8929459","GSM8929695","GSM8929694","GSM8929697","GSM8929696","GSM8930209","GSM8930208","GSM8930449","GSM8930207","GSM8930206","GSM8930448","GSM8930447","GSM8930205","GSM8930446","GSM8930204","GSM8930203","GSM8930445","GSM8930444","GSM8930202","GSM8930443","GSM8930201","GSM8930200","GSM8930442","GSM8930441","GSM8930440","GSM8929461","GSM8929467","GSM8929469","GSM8929463","GSM8929465","GSM8930219","GSM8930218","GSM8930217","GSM8930459","GSM8930458","GSM8930216","GSM8930215","GSM8930457","GSM8930214","GSM8930456","GSM8930455","GSM8930213","GSM8930212","GSM8930454","GSM8930453","GSM8930211","GSM8930452","GSM8930210","GSM8930451","GSM8930450","GSM8929671","GSM8929670","GSM8929677","GSM8929676","GSM8929679","GSM8929678","GSM8929673","GSM8929672","GSM8929675","GSM8929674","GSM8930429","GSM8930428","GSM8930427","GSM8930426","GSM8930425","GSM8930424","GSM8930423","GSM8930422","GSM8930421","GSM8930420","GSM8929680","GSM8929682","GSM8929681","GSM8929688","GSM8929687","GSM8929689","GSM8929684","GSM8929683","GSM8929686","GSM8929685","GSM8930439","GSM8930438","GSM8930437","GSM8930436","GSM8930435","GSM8930434","GSM8930433","GSM8930432","GSM8930431","GSM8930430","GSM8929891","GSM8929890","GSM8929897","GSM8929655","GSM8929654","GSM8929896","GSM8929657","GSM8929899","GSM8929656","GSM8929898","GSM8929651","GSM8929893","GSM8929892","GSM8929650","GSM8929653","GSM8929895","GSM8929894","GSM8929652","GSM8930409","GSM8930408","GSM8930407","GSM8930406","GSM8929659","GSM8929658","GSM8930405","GSM8930404","GSM8930403","GSM8930402","GSM8930401","GSM8930400","GSM8929660","GSM8929666","GSM8929665","GSM8929668","GSM8929667","GSM8929662","GSM8929661","GSM8929664","GSM8929663","GSM8930419","GSM8930418","GSM8930417","GSM8930416","GSM8929669","GSM8930415","GSM8930414","GSM8930413","GSM8930412","GSM8930411","GSM8930410","GSM8929633","GSM8929875","GSM8929874","GSM8929632","GSM8929877","GSM8929635","GSM8929634","GSM8929876","GSM8929871","GSM8929870","GSM8929631","GSM8929873","GSM8929630","GSM8929872","GSM8929879","GSM8929637","GSM8929636","GSM8929878","GSM8929639","GSM8929638","GSM8929880","GSM8929886","GSM8929644","GSM8929885","GSM8929643","GSM8929888","GSM8929646","GSM8929645","GSM8929887","GSM8929882","GSM8929640","GSM8929881","GSM8929642","GSM8929884","GSM8929883","GSM8929641","GSM8929648","GSM8929889","GSM8929647","GSM8929649","GSM8929611","GSM8929853","GSM8929610","GSM8929852","GSM8929613","GSM8929855","GSM8929854","GSM8929612","GSM8929851","GSM8929850","GSM8929619","GSM8929618","GSM8929857","GSM8929615","GSM8929614","GSM8929856","GSM8929859","GSM8929617","GSM8929616","GSM8929858","GSM8929622","GSM8929864","GSM8929863","GSM8929621","GSM8929866","GSM8929624","GSM8929865","GSM8929623","GSM8929860","GSM8929862","GSM8929620","GSM8929861","GSM8929629","GSM8929868","GSM8929626","GSM8929625","GSM8929867","GSM8929628","GSM8929869","GSM8929627","GSM8929831","GSM8929830","GSM8929833","GSM8929832","GSM8929838","GSM8929835","GSM8929834","GSM8929837","GSM8929836","GSM8929842","GSM8929600","GSM8929841","GSM8929602","GSM8929844","GSM8929843","GSM8929601","GSM8929840","GSM8929608","GSM8929849","GSM8929607","GSM8929609","GSM8929846","GSM8929604","GSM8929845","GSM8929603","GSM8929848","GSM8929606","GSM8929605","GSM8929847","GSM8929811","GSM8929810","GSM8929817","GSM8929816","GSM8929819","GSM8929818","GSM8929813","GSM8929812","GSM8929815","GSM8929814","GSM8929820","GSM8929822","GSM8929821","GSM8929828","GSM8929827","GSM8929829","GSM8929824","GSM8929823","GSM8929826","GSM8929825","GSM8929800","GSM8929806","GSM8929805","GSM8929808","GSM8929807","GSM8929802","GSM8929801","GSM8929804","GSM8929803","GSM8929809","GSM8930185","GSM8930184","GSM8930183","GSM8930182","GSM8930181","GSM8930180","GSM8930189","GSM8930188","GSM8930187","GSM8930186","GSM8930196","GSM8930195","GSM8930194","GSM8930193","GSM8930192","GSM8930191","GSM8930190","GSM8930199","GSM8930198","GSM8930197","GSM8930163","GSM8930162","GSM8930161","GSM8930160","GSM8930169","GSM8930168","GSM8930167","GSM8930166","GSM8930165","GSM8930164","GSM8930174","GSM8930173","GSM8930172","GSM8930171","GSM8930170","GSM8930179","GSM8930178","GSM8930177","GSM8930176","GSM8930175","GSM8930383","GSM8930141","GSM8930140","GSM8930382","GSM8930381","GSM8930380","GSM8930149","GSM8930148","GSM8930389","GSM8930147","GSM8930146","GSM8930388","GSM8930387","GSM8930145","GSM8930386","GSM8930144","GSM8930143","GSM8930385","GSM8930384","GSM8930142","GSM8930152","GSM8930394","GSM8930151","GSM8930393","GSM8930392","GSM8930150","GSM8930391","GSM8930390","GSM8930159","GSM8930158","GSM8930157","GSM8930399","GSM8930398","GSM8930156","GSM8930155","GSM8930397","GSM8930154","GSM8930396","GSM8930395","GSM8930153","GSM8930361","GSM8930360","GSM8930129","GSM8930128","GSM8930369","GSM8930127","GSM8930126","GSM8930368","GSM8930367","GSM8930125","GSM8930366",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