{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294936/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294936"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part16]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294936","cross_references":{"GSM":["GSM8930680","GSM8931539","GSM8931538","GSM8931537","GSM8931536","GSM8930689","GSM8931535","GSM8930688","GSM8930687","GSM8931534","GSM8931533","GSM8930686","GSM8931532","GSM8930685","GSM8930684","GSM8931531","GSM8931530","GSM8930683","GSM8930682","GSM8930681","GSM8930691","GSM8930690","GSM8931309","GSM8931308","GSM8931549","GSM8931307","GSM8931306","GSM8931548","GSM8931547","GSM8931305","GSM8931546","GSM8930699","GSM8931304","GSM8931303","GSM8931545","GSM8930698","GSM8930697","GSM8931544","GSM8931302","GSM8931543","GSM8930696","GSM8931301","GSM8931300","GSM8931542","GSM8930695","GSM8931541","GSM8930694","GSM8931540","GSM8930693","GSM8930692","GSM8931519","GSM8931518","GSM8931517","GSM8931516","GSM8930669","GSM8931515","GSM8930668","GSM8930667","GSM8931514","GSM8931513","GSM8930666","GSM8931512","GSM8930665","GSM8930664","GSM8931511","GSM8931510","GSM8930663","GSM8930662","GSM8930661","GSM8930660","GSM8931529","GSM8931528","GSM8931527","GSM8931526","GSM8930679","GSM8931525","GSM8930678","GSM8931524","GSM8930677","GSM8931523","GSM8930676","GSM8931522","GSM8930675","GSM8931521","GSM8930674","GSM8931520","GSM8930673","GSM8930672","GSM8930671","GSM8930670","GSM8930649","GSM8930648","GSM8930647","GSM8930889","GSM8930888","GSM8930646","GSM8930645","GSM8930887","GSM8930644","GSM8930886","GSM8930885","GSM8930643","GSM8930642","GSM8930884","GSM8930883","GSM8930641","GSM8930882","GSM8930640","GSM8930881","GSM8930880","GSM8931509","GSM8931508","GSM8931507","GSM8931506","GSM8930659","GSM8930658","GSM8931505","GSM8930899","GSM8931504","GSM8930657","GSM8931503","GSM8930656","GSM8930898","GSM8930897","GSM8930655","GSM8931502","GSM8930896","GSM8931501","GSM8930654","GSM8931500","GSM8930653","GSM8930895","GSM8930894","GSM8930652","GSM8930893","GSM8930651","GSM8930650","GSM8930892","GSM8930891","GSM8930890","GSM8930629","GSM8930628","GSM8930627","GSM8930869","GSM8930868","GSM8930626","GSM8930625","GSM8930867","GSM8930624","GSM8930866","GSM8930865","GSM8930623","GSM8930622","GSM8930864","GSM8930621","GSM8930863","GSM8930862","GSM8930620","GSM8930861","GSM8930860","GSM8930639","GSM8930638","GSM8930879","GSM8930637","GSM8930636","GSM8930878","GSM8930877","GSM8930635","GSM8930876","GSM8930634","GSM8930633","GSM8930875","GSM8930874","GSM8930632","GSM8930873","GSM8930631","GSM8930630","GSM8930872","GSM8930871","GSM8930870","GSM8930849","GSM8930848","GSM8930847","GSM8930846","GSM8930845","GSM8930844","GSM8930843","GSM8930842","GSM8930841","GSM8930840","GSM8930619","GSM8930618","GSM8930859","GSM8930617","GSM8930616","GSM8930858","GSM8930857","GSM8930615","GSM8930856","GSM8930614","GSM8930613","GSM8930855","GSM8930854","GSM8930612","GSM8930853","GSM8930611","GSM8930610","GSM8930852","GSM8930851","GSM8930850","GSM8930819","GSM8930818","GSM8930828","GSM8930827","GSM8930826","GSM8930825","GSM8930824","GSM8930823","GSM8930822","GSM8930821","GSM8930820","GSM8930829","GSM8930839","GSM8930838","GSM8930837","GSM8930836","GSM8930835","GSM8930834","GSM8930833","GSM8930832","GSM8930831","GSM8930830","GSM8930809","GSM8930808","GSM8930807","GSM8930817","GSM8930816","GSM8930815","GSM8930814","GSM8930813","GSM8930812","GSM8930811","GSM8930810","GSM8931098","GSM8931097","GSM8931096","GSM8931095","GSM8931094","GSM8931093","GSM8931092","GSM8931091","GSM8931090","GSM8931099","GSM8931076","GSM8931075","GSM8931074","GSM8931073","GSM8931072","GSM8931071","GSM8931070","GSM8931079","GSM8931078","GSM8931077","GSM8931087","GSM8931086","GSM8931085","GSM8931084","GSM8931083","GSM8931082","GSM8931081","GSM8931080","GSM8931089","GSM8931088","GSM8931054","GSM8931296","GSM8931295","GSM8931053","GSM8931294","GSM8931052","GSM8931051","GSM8931293","GSM8931292","GSM8931050","GSM8931291","GSM8931290","GSM8931059","GSM8931058","GSM8931057","GSM8931299","GSM8931298","GSM8931056","GSM8931297","GSM8931055","GSM8931065","GSM8931064","GSM8931063","GSM8931062","GSM8931061","GSM8931060","GSM8931069","GSM8931068","GSM8931067","GSM8931066","GSM8931274","GSM8931032","GSM8931031","GSM8931273","GSM8931272","GSM8931030","GSM8931271","GSM8931270","GSM8931039","GSM8931038","GSM8931037","GSM8931279","GSM8931278","GSM8931036","GSM8931277","GSM8931035","GSM8931034","GSM8931276","GSM8931275","GSM8931033","GSM8931043","GSM8931285","GSM8931042","GSM8931284","GSM8931283","GSM8931041","GSM8931040","GSM8931282","GSM8931281","GSM8931280","GSM8931049","GSM8931048","GSM8931289","GSM8931047","GSM8931288","GSM8931046","GSM8931045","GSM8931287","GSM8931286","GSM8931044","GSM8931252","GSM8931494","GSM8931010","GSM8931251","GSM8931493","GSM8931492","GSM8931250","GSM8931491","GSM8931490","GSM8931019","GSM8931018","GSM8931017","GSM8931259","GSM8931016","GSM8931258","GSM8931257","GSM8931015","GSM8931499","GSM8931014","GSM8931498","GSM8931256","GSM8931497","GSM8931255","GSM8931013","GSM8931254","GSM8931012","GSM8931496","GSM8931011","GSM8931495","GSM8931253","GSM8931263","GSM8931021","GSM8931020","GSM8931262",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