{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294958/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294958"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part17]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294958","cross_references":{"GSM":["GSM8932860","GSM8932861","GSM8932620","GSM8932862","GSM8932621","GSM8932863","GSM8932864","GSM8932622","GSM8932623","GSM8932865","GSM8932866","GSM8932624","GSM8932867","GSM8932625","GSM8932626","GSM8932868","GSM8932869","GSM8932627","GSM8932628","GSM8932629","GSM8932870","GSM8932871","GSM8932872","GSM8932630","GSM8932873","GSM8932631","GSM8932632","GSM8932874","GSM8932875","GSM8932633","GSM8932876","GSM8932634","GSM8932635","GSM8932877","GSM8932878","GSM8932636","GSM8932637","GSM8932879","GSM8932638","GSM8932639","GSM8932840","GSM8932841","GSM8932600","GSM8932842","GSM8932601","GSM8932843","GSM8932844","GSM8932602","GSM8932603","GSM8932845","GSM8932846","GSM8932604","GSM8932847","GSM8932605","GSM8932606","GSM8932848","GSM8932849","GSM8932607","GSM8932608","GSM8932609","GSM8931999","GSM8931998","GSM8931997","GSM8931996","GSM8931995","GSM8931994","GSM8931993","GSM8931992","GSM8931991","GSM8931990","GSM8932850","GSM8932851","GSM8932852","GSM8932610","GSM8932853","GSM8932611","GSM8932612","GSM8932854","GSM8932855","GSM8932613","GSM8932856","GSM8932614","GSM8932615","GSM8932857","GSM8932858","GSM8932616","GSM8932617","GSM8932859","GSM8932618","GSM8932619","GSM8932820","GSM8932821","GSM8932822","GSM8932823","GSM8932824","GSM8932825","GSM8932826","GSM8932827","GSM8932828","GSM8932829","GSM8932830","GSM8932831","GSM8932832","GSM8932833","GSM8932834","GSM8932835","GSM8932836","GSM8932837","GSM8932838","GSM8932839","GSM8931989","GSM8931988","GSM8931987","GSM8931986","GSM8931985","GSM8931984","GSM8931983","GSM8931982","GSM8932800","GSM8932801","GSM8932802","GSM8932803","GSM8932804","GSM8932805","GSM8932806","GSM8932807","GSM8932808","GSM8932810","GSM8932811","GSM8932812","GSM8932813","GSM8932814","GSM8932815","GSM8932816","GSM8932817","GSM8932818","GSM8932819","GSM8932809","GSM8932188","GSM8932189","GSM8932180","GSM8932181","GSM8932182","GSM8932183","GSM8932184","GSM8932185","GSM8932186","GSM8932187","GSM8932199","GSM8932190","GSM8932191","GSM8932192","GSM8932193","GSM8932194","GSM8932195","GSM8932196","GSM8932197","GSM8932198","GSM8933013","GSM8932166","GSM8933014","GSM8932167","GSM8933015","GSM8932168","GSM8933016","GSM8932169","GSM8933017","GSM8933018","GSM8933019","GSM8932160","GSM8932161","GSM8932162","GSM8933010","GSM8932163","GSM8933011","GSM8932164","GSM8933012","GSM8932165","GSM8932177","GSM8932178","GSM8932179","GSM8932170","GSM8932171","GSM8932172","GSM8932173","GSM8932174","GSM8932175","GSM8932176","GSM8932386","GSM8932144","GSM8932145","GSM8932387","GSM8932388","GSM8932146","GSM8932389","GSM8932147","GSM8932148","GSM8932149","GSM8932380","GSM8932381","GSM8932140","GSM8932382","GSM8932383","GSM8932141","GSM8932142","GSM8932384","GSM8932143","GSM8932385","GSM8932397","GSM8932155","GSM8933002","GSM8932398","GSM8933003","GSM8932156","GSM8933004","GSM8932157","GSM8932399","GSM8933005","GSM8932158","GSM8932159","GSM8933006","GSM8933007","GSM8933008","GSM8933009","GSM8932390","GSM8932391","GSM8932392","GSM8932150","GSM8932151","GSM8932393","GSM8932394","GSM8932152","GSM8932395","GSM8933000","GSM8932153","GSM8933001","GSM8932154","GSM8932396","GSM8932122","GSM8932364","GSM8932365","GSM8932123","GSM8932366","GSM8932124","GSM8932125","GSM8932367","GSM8932368","GSM8932126","GSM8932369","GSM8932127","GSM8932128","GSM8932129","GSM8932360","GSM8932361","GSM8932120","GSM8932362","GSM8932363","GSM8932121","GSM8932375","GSM8932133","GSM8932134","GSM8932376","GSM8932377","GSM8932135","GSM8932136","GSM8932378","GSM8932137","GSM8932379","GSM8932138","GSM8932139","GSM8932370","GSM8932371","GSM8932372","GSM8932130","GSM8932131","GSM8932373","GSM8932374","GSM8932132","GSM8932100","GSM8932584","GSM8932342","GSM8932343","GSM8932101","GSM8932585","GSM8932586","GSM8932102","GSM8932344","GSM8932345","GSM8932103","GSM8932587","GSM8932346","GSM8932104","GSM8932588","GSM8932105","GSM8932589","GSM8932347","GSM8932348","GSM8932106","GSM8932349","GSM8932107","GSM8932108","GSM8932109","GSM8932580","GSM8932581","GSM8932340","GSM8932582","GSM8932583","GSM8932341","GSM8932595","GSM8932111","GSM8932353","GSM8932354","GSM8932596","GSM8932112","GSM8932597","GSM8932355","GSM8932113","GSM8932114","GSM8932598","GSM8932356","GSM8932357","GSM8932115","GSM8932599","GSM8932116","GSM8932358","GSM8932117","GSM8932359","GSM8932118","GSM8932119","GSM8932590","GSM8932591","GSM8932592","GSM8932350","GSM8932351","GSM8932593","GSM8932594","GSM8932352","GSM8932110","GSM8932320","GSM8932562","GSM8932563","GSM8932321","GSM8932564","GSM8932322","GSM8932323","GSM8932565","GSM8932566","GSM8932324","GSM8932325","GSM8932567","GSM8932326","GSM8932568","GSM8932569","GSM8932327","GSM8932328","GSM8932329","GSM8932560","GSM8932561","GSM8932331","GSM8932573","GSM8932574","GSM8932332","GSM8932575","GSM8932333","GSM8932334","GSM8932576","GSM8932577","GSM8932335","GSM8932578","GSM8932336","GSM8932337","GSM8932579","GSM8932338","GSM8932339","GSM8932570","GSM8932571","GSM8932572",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