{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294968/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294968"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part18]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294968","cross_references":{"GSM":["GSM8933950","GSM8933951","GSM8933952","GSM8933710","GSM8933711","GSM8933953","GSM8933712","GSM8933954","GSM8933955","GSM8933713","GSM8933714","GSM8933956","GSM8933715","GSM8933957","GSM8933958","GSM8933716","GSM8933717","GSM8933959","GSM8933718","GSM8933719","GSM8933960","GSM8933961","GSM8933720","GSM8933962","GSM8933963","GSM8933721","GSM8933964","GSM8933722","GSM8933723","GSM8933965","GSM8933966","GSM8933724","GSM8933967","GSM8933725","GSM8933726","GSM8933968","GSM8933969","GSM8933727","GSM8933728","GSM8933729","GSM8933930","GSM8933931","GSM8933932","GSM8933933","GSM8933934","GSM8933935","GSM8933936","GSM8933937","GSM8933938","GSM8933939","GSM8933940","GSM8933941","GSM8933700","GSM8933942","GSM8933943","GSM8933701","GSM8933944","GSM8933702","GSM8933703","GSM8933945","GSM8933946","GSM8933704","GSM8933947","GSM8933705","GSM8933706","GSM8933948","GSM8933949","GSM8933707","GSM8933708","GSM8933709","GSM8933910","GSM8933911","GSM8933912","GSM8933913","GSM8933914","GSM8933915","GSM8933916","GSM8933917","GSM8933918","GSM8933919","GSM8933909","GSM8933920","GSM8933921","GSM8933922","GSM8933923","GSM8933924","GSM8933925","GSM8933926","GSM8933927","GSM8933928","GSM8933929","GSM8933900","GSM8933901","GSM8933902","GSM8933903","GSM8933904","GSM8933905","GSM8933906","GSM8933907","GSM8933908","GSM8934181","GSM8934180","GSM8934183","GSM8934182","GSM8934185","GSM8934184","GSM8934187","GSM8934186","GSM8934189","GSM8934188","GSM8934190","GSM8934192","GSM8934191","GSM8934194","GSM8934193","GSM8934196","GSM8934195","GSM8934198","GSM8934197","GSM8934199","GSM8934169","GSM8934168","GSM8934161","GSM8934160","GSM8934163","GSM8934162","GSM8934165","GSM8934164","GSM8934167","GSM8934166","GSM8934179","GSM8934170","GSM8934172","GSM8934171","GSM8934174","GSM8934173","GSM8934176","GSM8934175","GSM8934178","GSM8934177","GSM8933299","GSM8934147","GSM8934146","GSM8934149","GSM8934148","GSM8933290","GSM8933291","GSM8933292","GSM8934141","GSM8933293","GSM8933294","GSM8934140","GSM8933295","GSM8934143","GSM8933296","GSM8934142","GSM8933297","GSM8934145","GSM8934144","GSM8933298","GSM8934158","GSM8934157","GSM8934159","GSM8934150","GSM8934152","GSM8934151","GSM8934154","GSM8934153","GSM8934156","GSM8934155","GSM8933277","GSM8934125","GSM8934124","GSM8933278","GSM8933279","GSM8934127","GSM8934126","GSM8934129","GSM8934128","GSM8933270","GSM8933271","GSM8933272","GSM8933273","GSM8934121","GSM8933274","GSM8934120","GSM8933275","GSM8934123","GSM8933276","GSM8934122","GSM8933288","GSM8934136","GSM8934135","GSM8933289","GSM8934138","GSM8934137","GSM8934139","GSM8933280","GSM8933281","GSM8933282","GSM8934130","GSM8933283","GSM8934132","GSM8933284","GSM8933285","GSM8934131","GSM8933286","GSM8934134","GSM8934133","GSM8933287","GSM8933497","GSM8934103","GSM8934102","GSM8933498","GSM8934105","GSM8933499","GSM8934104","GSM8934107","GSM8934106","GSM8934109","GSM8934108","GSM8933490","GSM8933491","GSM8933492","GSM8933493","GSM8933494","GSM8934101","GSM8933495","GSM8933496","GSM8934100","GSM8933266","GSM8934114","GSM8934113","GSM8933267","GSM8933268","GSM8934116","GSM8934115","GSM8933269","GSM8934118","GSM8934117","GSM8934119","GSM8933260","GSM8933261","GSM8933262","GSM8934110","GSM8933263","GSM8934112","GSM8933264","GSM8933265","GSM8934111","GSM8933475","GSM8933476","GSM8933477","GSM8933478","GSM8933479","GSM8933470","GSM8933471","GSM8933472","GSM8933473","GSM8933474","GSM8933486","GSM8933487","GSM8933488","GSM8933489","GSM8933480","GSM8933481","GSM8933482","GSM8933483","GSM8933484","GSM8933485","GSM8933695","GSM8933453","GSM8933454","GSM8933696","GSM8933697","GSM8933455","GSM8933698","GSM8933456","GSM8933457","GSM8933699","GSM8933458","GSM8933459","GSM8933690","GSM8933691","GSM8933692","GSM8933450","GSM8933451","GSM8933693","GSM8933694","GSM8933452","GSM8933464","GSM8933465","GSM8933466","GSM8933467","GSM8933468","GSM8933469","GSM8933460","GSM8933461","GSM8933462","GSM8933463","GSM8933431","GSM8933673","GSM8933674","GSM8933432","GSM8933675","GSM8933433","GSM8933434","GSM8933676","GSM8933677","GSM8933435","GSM8933678","GSM8933436","GSM8933437","GSM8933679","GSM8933438","GSM8933439","GSM8933670","GSM8933671","GSM8933672","GSM8933430","GSM8933442","GSM8933684","GSM8933443","GSM8933685","GSM8933686","GSM8933444","GSM8933445","GSM8933687","GSM8933446","GSM8933688","GSM8933689","GSM8933447","GSM8933448","GSM8933449","GSM8933680","GSM8933681","GSM8933440","GSM8933682","GSM8933683","GSM8933441","GSM8933651","GSM8933893","GSM8933652","GSM8933410","GSM8933894","GSM8933411","GSM8933895","GSM8933653","GSM8933654","GSM8933412","GSM8933896","GSM8933897","GSM8933655","GSM8933413","GSM8933414","GSM8933898","GSM8933656","GSM8933657","GSM8933899","GSM8933415","GSM8933658","GSM8933416","GSM8933417","GSM8933659","GSM8933418","GSM8933419","GSM8933890","GSM8933891","GSM8933892","GSM8933650","GSM8933420","GSM8933662","GSM8933663","GSM8933421","GSM8933422","GSM8933664","GSM8933423","GSM8933665","GSM8933666","GSM8933424","GSM8933425","GSM8933667","GSM8933668","GSM8933426","GSM8933669","GSM8933427","GSM8933428","GSM8933429","GSM8933660","GSM8933661","GSM8933871","GSM8933872","GSM8933630","GSM8933631","GSM8933873","GSM8933632","GSM8933874","GSM8933875","GSM8933633","GSM8933634","GSM8933876","GSM8933877","GSM8933635","GSM8933878","GSM8933636","GSM8933637","GSM8933879","GSM8933638","GSM8933639","GSM8933870","GSM8933640","GSM8933882","GSM8933883","GSM8933641","GSM8933400","GSM8933884","GSM8933642","GSM8933643","GSM8933401","GSM8933885","GSM8933402","GSM8933886","GSM8933644","GSM8933403","GSM8933887","GSM8933645","GSM8933646","GSM8933888","GSM8933404","GSM8933405","GSM8933889","GSM8933647","GSM8933648","GSM8933406","GSM8933649","GSM8933407","GSM8933408","GSM8933409","GSM8933880","GSM8933881","GSM8933850","GSM8933851","GSM8933852","GSM8933610","GSM8933611","GSM8933853","GSM8933612","GSM8933854","GSM8933855","GSM8933613","GSM8933614","GSM8933856","GSM8933857","GSM8933615","GSM8933858","GSM8933616","GSM8933617","GSM8933859","GSM8933618","GSM8933619","GSM8933860","GSM8933861","GSM8933620","GSM8933862","GSM8933863","GSM8933621","GSM8933864","GSM8933622","GSM8933623","GSM8933865","GSM8933866","GSM8933624","GSM8933867","GSM8933625","GSM8933626","GSM8933868","GSM8933869","GSM8933627","GSM8933628","GSM8933629","GSM8933830","GSM8933831","GSM8933832","GSM8933833","GSM8933834","GSM8933835","GSM8933836","GSM8933837","GSM8933838","GSM8933839","GSM8933840","GSM8933841","GSM8933600","GSM8933842","GSM8933843","GSM8933601","GSM8933844","GSM8933602","GSM8933603","GSM8933845","GSM8933846","GSM8933604","GSM8933847","GSM8933605","GSM8933606","GSM8933848","GSM8933849","GSM8933607","GSM8933608","GSM8933609","GSM8933810","GSM8933811","GSM8933812","GSM8933813","GSM8933814","GSM8933815","GSM8933816","GSM8933817","GSM8933818","GSM8933819","GSM8933820","GSM8933821","GSM8933822","GSM8933823","GSM8933824","GSM8933825","GSM8933826","GSM8933827","GSM8933828","GSM8933829","GSM8933800","GSM8933801","GSM8933802","GSM8933803","GSM8933804","GSM8933805","GSM8933806","GSM8933807","GSM8933808","GSM8933809","GSM8934080","GSM8934082","GSM8934081","GSM8934084","GSM8934083","GSM8934086","GSM8934085","GSM8934088","GSM8934087","GSM8934089","GSM8934091","GSM8934090","GSM8934093","GSM8934092","GSM8934095","GSM8934094","GSM8934097","GSM8934096","GSM8934099","GSM8934098","GSM8934069","GSM8934060","GSM8934062","GSM8934061","GSM8934064","GSM8934063","GSM8934066","GSM8934065","GSM8934068","GSM8934067","GSM8934071","GSM8934070","GSM8934073","GSM8934072","GSM8934075","GSM8934074","GSM8934077","GSM8934076","GSM8934079","GSM8934078","GSM8934048","GSM8934047","GSM8934049","GSM8934040","GSM8934042","GSM8934041","GSM8934044","GSM8934043","GSM8934046","GSM8934045","GSM8934059","GSM8934058","GSM8934051","GSM8934050","GSM8934053","GSM8934052","GSM8934055","GSM8934054","GSM8934057","GSM8934056","GSM8934026","GSM8934025","GSM8934028","GSM8934027","GSM8934029","GSM8934020","GSM8934022","GSM8934021","GSM8934024","GSM8934023","GSM8934037","GSM8934036","GSM8934039","GSM8934038","GSM8934031","GSM8934030","GSM8934033","GSM8934032","GSM8934035","GSM8934034","GSM8934004","GSM8933398","GSM8934246","GSM8934003","GSM8933399","GSM8934245","GSM8934006","GSM8934248","GSM8934247","GSM8934005","GSM8934008","GSM8934007","GSM8934249","GSM8934009","GSM8933390","GSM8933391","GSM8933392","GSM8934240","GSM8933393","GSM8933394","GSM8934242","GSM8934000","GSM8934241","GSM8933395","GSM8934244","GSM8934002","GSM8933396","GSM8934001","GSM8933397","GSM8934243","GSM8934015","GSM8934257","GSM8934256","GSM8934014","GSM8934259","GSM8934017","GSM8934258","GSM8934016","GSM8934019","GSM8934018","GSM8934251","GSM8934250","GSM8934253","GSM8934011","GSM8934252","GSM8934010","GSM8934255","GSM8934013","GSM8934012","GSM8934254","GSM8934224","GSM8933376","GSM8933377","GSM8934223","GSM8933378","GSM8934226","GSM8933379","GSM8934225","GSM8934228","GSM8934227","GSM8934229","GSM8933370","GSM8933371","GSM8933372","GSM8934220","GSM8933373","GSM8933374","GSM8934222","GSM8934221","GSM8933375","GSM8934235","GSM8933387","GSM8933388","GSM8934234","GSM8933389","GSM8934237","GSM8934236","GSM8934239","GSM8934238","GSM8933380","GSM8933381","GSM8933382","GSM8933383","GSM8934231","GSM8934230","GSM8933384","GSM8933385","GSM8934233","GSM8934232","GSM8933386","GSM8933354","GSM8933596","GSM8934202","GSM8933597","GSM8934201","GSM8933355","GSM8933356","GSM8934204","GSM8933598","GSM8933357","GSM8934203","GSM8933599","GSM8933358","GSM8934206","GSM8933359","GSM8934205","GSM8934208","GSM8934207","GSM8934209","GSM8933590","GSM8933591","GSM8933592","GSM8933350","GSM8933351","GSM8933593","GSM8933594","GSM8933352","GSM8934200","GSM8933595","GSM8933353","GSM8933365","GSM8934213","GSM8934212","GSM8933366","GSM8934215","GSM8933367","GSM8933368","GSM8934214","GSM8933369","GSM8934217","GSM8934216","GSM8934219","GSM8934218","GSM8933360","GSM8933361","GSM8933362","GSM8933363","GSM8934211","GSM8934210","GSM8933364","GSM8933574","GSM8933332","GSM8933575","GSM8933333","GSM8933334","GSM8933576","GSM8933577","GSM8933335","GSM8933336","GSM8933578","GSM8933337","GSM8933579","GSM8933338","GSM8933339","GSM8933570","GSM8933571","GSM8933572","GSM8933330","GSM8933331","GSM8933573","GSM8933585","GSM8933343","GSM8933586","GSM8933344","GSM8933345","GSM8933587","GSM8933588","GSM8933346","GSM8933589","GSM8933347","GSM8933348","GSM8933349","GSM8933580","GSM8933581","GSM8933340","GSM8933582","GSM8933583","GSM8933341","GSM8933342","GSM8933584","GSM8933794","GSM8933552","GSM8933310","GSM8933311","GSM8933795","GSM8933553","GSM8933554","GSM8933796","GSM8933312","GSM8933797","GSM8933555","GSM8933313","GSM8933314","GSM8933798","GSM8933556","GSM8933557","GSM8933799","GSM8933315","GSM8933316","GSM8933558","GSM8933317","GSM8933559","GSM8933318","GSM8933319","GSM8933790","GSM8933791","GSM8933792","GSM8933550","GSM8933551","GSM8933793","GSM8933563","GSM8933321","GSM8933322","GSM8933564","GSM8933565","GSM8933323","GSM8933566","GSM8933324","GSM8933325","GSM8933567","GSM8933568","GSM8933326","GSM8933569","GSM8933327","GSM8933328","GSM8933329","GSM8933560","GSM8933561","GSM8933320","GSM8933562","GSM8933772","GSM8933530","GSM8933531","GSM8933773","GSM8933774","GSM8933532","GSM8933775","GSM8933533","GSM8933534","GSM8933776","GSM8933777","GSM8933535","GSM8933778","GSM8933536","GSM8933537","GSM8933779","GSM8933538","GSM8933539","GSM8933770","GSM8933771","GSM8933783","GSM8933541","GSM8933300","GSM8933784","GSM8933542","GSM8933543","GSM8933785","GSM8933301","GSM8933302","GSM8933786","GSM8933544","GSM8933545","GSM8933303","GSM8933787","GSM8933546","GSM8933304","GSM8933788","GSM8933305","GSM8933789","GSM8933547","GSM8933548","GSM8933306","GSM8933549","GSM8933307","GSM8933308","GSM8933309","GSM8933780","GSM8933781","GSM8933540","GSM8933782","GSM8933992","GSM8933750","GSM8933993","GSM8933751","GSM8933752","GSM8933994","GSM8933510","GSM8933995","GSM8933511","GSM8933753","GSM8933754","GSM8933512","GSM8933996","GSM8933755","GSM8933513","GSM8933997","GSM8933514","GSM8933998","GSM8933756","GSM8933757","GSM8933515","GSM8933999","GSM8933758","GSM8933516","GSM8933517","GSM8933759","GSM8933518","GSM8933519","GSM8933990","GSM8933991","GSM8933761","GSM8933520","GSM8933762","GSM8933763","GSM8933521","GSM8933764","GSM8933522","GSM8933523","GSM8933765","GSM8933766","GSM8933524","GSM8933525","GSM8933767","GSM8933526","GSM8933768","GSM8933769","GSM8933527","GSM8933528","GSM8933529","GSM8933760","GSM8933970","GSM8933971","GSM8933972","GSM8933730","GSM8933731","GSM8933973","GSM8933732","GSM8933974","GSM8933975","GSM8933733","GSM8933734","GSM8933976","GSM8933735","GSM8933977","GSM8933978","GSM8933736","GSM8933737","GSM8933979","GSM8933738","GSM8933739","GSM8933981","GSM8933740","GSM8933982","GSM8933983","GSM8933741","GSM8933500","GSM8933984","GSM8933742","GSM8933743","GSM8933985","GSM8933501","GSM8933986","GSM8933502","GSM8933744","GSM8933503","GSM8933987","GSM8933745","GSM8933746","GSM8933504","GSM8933988","GSM8933505","GSM8933989","GSM8933747","GSM8933506","GSM8933748","GSM8933749","GSM8933507","GSM8933508","GSM8933509","GSM8933980"],"GPL":["24247"],"GSE":["294968"],"taxon":["Mus musculus"]}}