{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294978/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294978"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part19]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294978","cross_references":{"GSM":["GSM8934800","GSM8934802","GSM8934801","GSM8934804","GSM8934803","GSM8934806","GSM8934805","GSM8934808","GSM8934807","GSM8934809","GSM8934811","GSM8934810","GSM8934813","GSM8934812","GSM8934815","GSM8934814","GSM8934817","GSM8934816","GSM8934819","GSM8934818","GSM8935090","GSM8935092","GSM8935091","GSM8935094","GSM8935093","GSM8935096","GSM8935095","GSM8935098","GSM8935097","GSM8935099","GSM8935070","GSM8935072","GSM8935071","GSM8935074","GSM8935073","GSM8935076","GSM8935075","GSM8935078","GSM8935077","GSM8935079","GSM8935081","GSM8935080","GSM8935083","GSM8935082","GSM8935085","GSM8935084","GSM8935087","GSM8935086","GSM8935089","GSM8935088","GSM8935059","GSM8935290","GSM8935292","GSM8935050","GSM8935291","GSM8935052","GSM8935294","GSM8935293","GSM8935051","GSM8935296","GSM8935054","GSM8935295","GSM8935053","GSM8935298","GSM8935056","GSM8935055","GSM8935297","GSM8935058","GSM8935057","GSM8935299","GSM8935061","GSM8935060","GSM8935063","GSM8935062","GSM8935065","GSM8935064","GSM8935067","GSM8935066","GSM8935069","GSM8935068","GSM8935038","GSM8935037","GSM8935279","GSM8935039","GSM8935270","GSM8935272","GSM8935030","GSM8935271","GSM8935032","GSM8935274","GSM8935273","GSM8935031","GSM8935034","GSM8935276","GSM8935275","GSM8935033","GSM8935278","GSM8935036","GSM8935035","GSM8935277","GSM8935049","GSM8935048","GSM8935281","GSM8935280","GSM8935041","GSM8935283","GSM8935040","GSM8935282","GSM8935043","GSM8935285","GSM8935284","GSM8935042","GSM8935287","GSM8935045","GSM8935286","GSM8935044","GSM8935289","GSM8935047","GSM8935046","GSM8935288","GSM8935258","GSM8935016","GSM8935015","GSM8935257","GSM8935018","GSM8935017","GSM8935259","GSM8935019","GSM8935250","GSM8935252","GSM8935010","GSM8935251","GSM8935012","GSM8935254","GSM8935253","GSM8935011","GSM8935014","GSM8935256","GSM8935255","GSM8935013","GSM8935269","GSM8935027","GSM8935026","GSM8935268","GSM8935029","GSM8935028","GSM8935261","GSM8935260","GSM8935263","GSM8935021","GSM8935020","GSM8935262","GSM8935023","GSM8935265","GSM8935264","GSM8935022","GSM8935267","GSM8935025","GSM8935266","GSM8935024","GSM8935236","GSM8934389","GSM8935235","GSM8934388","GSM8935238","GSM8935237","GSM8935239","GSM8934381","GSM8934380","GSM8935230","GSM8934383","GSM8934382","GSM8935232","GSM8934385","GSM8935231","GSM8934384","GSM8935234","GSM8934387","GSM8935233","GSM8934386","GSM8935247","GSM8935005","GSM8935246","GSM8934399","GSM8935004","GSM8935249","GSM8935007","GSM8935006","GSM8935248","GSM8935009","GSM8935008","GSM8934390","GSM8934392","GSM8934391","GSM8935241","GSM8934394","GSM8934393","GSM8935240","GSM8935243","GSM8934396","GSM8935001","GSM8935000","GSM8935242","GSM8934395","GSM8935003","GSM8935245","GSM8934398","GSM8935244","GSM8934397","GSM8935002","GSM8935214","GSM8935213","GSM8935216","GSM8935215","GSM8935218","GSM8935217","GSM8935219","GSM8935210","GSM8935212","GSM8935211","GSM8935225","GSM8935224","GSM8935227","GSM8935226","GSM8934379","GSM8935229","GSM8935228","GSM8935221","GSM8935220","GSM8935223","GSM8935222","GSM8934587","GSM8934586","GSM8934589","GSM8934588","GSM8934581","GSM8934580","GSM8934583","GSM8934582","GSM8934585","GSM8934584","GSM8935203","GSM8934598","GSM8934597","GSM8935202","GSM8935205","GSM8934599","GSM8935204","GSM8935207","GSM8935206","GSM8935209","GSM8935208","GSM8934590","GSM8934592","GSM8934591","GSM8934594","GSM8934593","GSM8935201","GSM8934596","GSM8934595","GSM8935200","GSM8934565","GSM8934564","GSM8934567","GSM8934566","GSM8934569","GSM8934568","GSM8934561","GSM8934560","GSM8934563","GSM8934562","GSM8934576","GSM8934575","GSM8934578","GSM8934577","GSM8934579","GSM8934570","GSM8934572","GSM8934571","GSM8934574","GSM8934573","GSM8934785","GSM8934543","GSM8934542","GSM8934784","GSM8934545","GSM8934787","GSM8934786","GSM8934544","GSM8934789","GSM8934547","GSM8934788","GSM8934546","GSM8934549","GSM8934548","GSM8934781","GSM8934780","GSM8934783","GSM8934541","GSM8934540","GSM8934782","GSM8934554","GSM8934796","GSM8934795","GSM8934553","GSM8934556","GSM8934798","GSM8934797","GSM8934555","GSM8934558","GSM8934557","GSM8934799","GSM8934559","GSM8934790","GSM8934792","GSM8934550","GSM8934791","GSM8934794","GSM8934552","GSM8934551","GSM8934793","GSM8934763","GSM8934521","GSM8934520","GSM8934762","GSM8934765","GSM8934523","GSM8934522","GSM8934764","GSM8934525","GSM8934767","GSM8934766","GSM8934524","GSM8934769","GSM8934527","GSM8934768","GSM8934526","GSM8934529","GSM8934528","GSM8934761","GSM8934760","GSM8934774","GSM8934532","GSM8934531","GSM8934773","GSM8934534","GSM8934776","GSM8934775","GSM8934533","GSM8934536","GSM8934778","GSM8934777","GSM8934535","GSM8934538","GSM8934537","GSM8934779","GSM8934539","GSM8934770","GSM8934772","GSM8934530","GSM8934771","GSM8934983","GSM8934741","GSM8934740","GSM8934982","GSM8934743","GSM8934501","GSM8934985","GSM8934500","GSM8934984","GSM8934742","GSM8934745","GSM8934503","GSM8934987","GSM8934502","GSM8934986","GSM8934744",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