{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294983/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294983"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part20]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294983","cross_references":{"GSM":["GSM8935900","GSM8935902","GSM8935901","GSM8935904","GSM8935903","GSM8935906","GSM8935905","GSM8935908","GSM8935907","GSM8935909","GSM8936182","GSM8936183","GSM8936180","GSM8936181","GSM8936186","GSM8936187","GSM8936184","GSM8936185","GSM8936188","GSM8936189","GSM8936190","GSM8936193","GSM8936194","GSM8936191","GSM8936192","GSM8936197","GSM8936198","GSM8936195","GSM8936196","GSM8936199","GSM8936160","GSM8936161","GSM8936164","GSM8936165","GSM8936162","GSM8936163","GSM8936168","GSM8936169","GSM8936166","GSM8936167","GSM8936171","GSM8936172","GSM8936170","GSM8936175","GSM8936176","GSM8936173","GSM8936174","GSM8936179","GSM8936177","GSM8936178","GSM8936148","GSM8936149","GSM8936380","GSM8936381","GSM8936142","GSM8936143","GSM8936140","GSM8936383","GSM8936141","GSM8936146","GSM8936388","GSM8936147","GSM8936386","GSM8936144","GSM8936145","GSM8936159","GSM8936392","GSM8936150","GSM8936390","GSM8936395","GSM8936153","GSM8936154","GSM8936396","GSM8936151","GSM8936394","GSM8936152","GSM8936157","GSM8936399","GSM8936158","GSM8936397","GSM8936155","GSM8936398","GSM8936156","GSM8936128","GSM8936129","GSM8936126","GSM8936368","GSM8936369","GSM8936127","GSM8936120","GSM8936362","GSM8936363","GSM8936121","GSM8936360","GSM8936361","GSM8936366","GSM8936124","GSM8936125","GSM8936367","GSM8936364","GSM8936122","GSM8936123","GSM8936365","GSM8936139","GSM8936137","GSM8936379","GSM8936138","GSM8936370","GSM8936131","GSM8936373","GSM8936374","GSM8936132","GSM8936371","GSM8936372","GSM8936130","GSM8936377","GSM8936135","GSM8936378","GSM8936136","GSM8936375","GSM8936133","GSM8936134","GSM8936376","GSM8936106","GSM8936348","GSM8936349","GSM8935499","GSM8936107","GSM8936346","GSM8936104","GSM8936105","GSM8936347","GSM8936108","GSM8936109","GSM8935490","GSM8936340","GSM8935492","GSM8936341","GSM8935491","GSM8935494","GSM8935493","GSM8936102","GSM8935496","GSM8936344","GSM8936103","GSM8935495","GSM8936345","GSM8936100","GSM8936342","GSM8935498","GSM8936343","GSM8936101","GSM8935497","GSM8936117","GSM8936359","GSM8936118","GSM8936357","GSM8936115","GSM8936358","GSM8936116","GSM8936119","GSM8936351","GSM8936352","GSM8936110","GSM8936350","GSM8936355","GSM8936113","GSM8936114","GSM8936356","GSM8936111","GSM8936353","GSM8936354","GSM8936112","GSM8935478","GSM8936326","GSM8936327","GSM8935477","GSM8936324","GSM8935479","GSM8936325","GSM8936328","GSM8936329","GSM8935470","GSM8935472","GSM8935471","GSM8935474","GSM8936322","GSM8936323","GSM8935473","GSM8936320","GSM8935476","GSM8936321","GSM8935475","GSM8936337","GSM8935489","GSM8936338","GSM8935488","GSM8936335","GSM8936336","GSM8936339","GSM8935481","GSM8936330","GSM8935480","GSM8935483","GSM8935482","GSM8935485","GSM8936333","GSM8935484","GSM8936334","GSM8936331","GSM8935487","GSM8936332","GSM8935486","GSM8935456","GSM8936304","GSM8935698","GSM8935697","GSM8936305","GSM8935455","GSM8935458","GSM8936302","GSM8936303","GSM8935699","GSM8935457","GSM8936308","GSM8936309","GSM8935459","GSM8936306","GSM8936307","GSM8935690","GSM8935450","GSM8935692","GSM8935691","GSM8936300","GSM8935694","GSM8935452","GSM8935693","GSM8935451","GSM8936301","GSM8935696","GSM8935454","GSM8935453","GSM8935695","GSM8935467","GSM8936315","GSM8935466","GSM8936316","GSM8936313","GSM8935469","GSM8936314","GSM8935468","GSM8936319","GSM8936317","GSM8936318","GSM8935461","GSM8935460","GSM8936311","GSM8935463","GSM8936312","GSM8935462","GSM8935465","GSM8935464","GSM8936310","GSM8935676","GSM8935434","GSM8935433","GSM8935675","GSM8935436","GSM8935678","GSM8935677","GSM8935435","GSM8935438","GSM8935679","GSM8935437","GSM8935439","GSM8935670","GSM8935430","GSM8935672","GSM8935671","GSM8935674","GSM8935432","GSM8935673","GSM8935431","GSM8935687","GSM8935445","GSM8935444","GSM8935686","GSM8935447","GSM8935689","GSM8935688","GSM8935446","GSM8935449","GSM8935448","GSM8935681","GSM8935680","GSM8935441","GSM8935683","GSM8935682","GSM8935440","GSM8935685","GSM8935443","GSM8935442","GSM8935684","GSM8935896","GSM8935654","GSM8935653","GSM8935895","GSM8935656","GSM8935898","GSM8935897","GSM8935655","GSM8935416","GSM8935658","GSM8935899","GSM8935657","GSM8935418","GSM8935659","GSM8935417","GSM8935419","GSM8935890","GSM8935650","GSM8935892","GSM8935891","GSM8935894","GSM8935652","GSM8935651","GSM8935893","GSM8935665","GSM8935423","GSM8935422","GSM8935664","GSM8935667","GSM8935425","GSM8935424","GSM8935666","GSM8935427","GSM8935669","GSM8935668","GSM8935426","GSM8935429","GSM8935428","GSM8935661","GSM8935660","GSM8935421","GSM8935663","GSM8935662","GSM8935420","GSM8935874","GSM8935632","GSM8935873","GSM8935631","GSM8935876","GSM8935634","GSM8935633","GSM8935875","GSM8935636","GSM8935878","GSM8935877","GSM8935635","GSM8935638","GSM8935879","GSM8935637","GSM8935639","GSM8935870","GSM8935630","GSM8935872","GSM8935871","GSM8935885","GSM8935643","GSM8935642","GSM8935884","GSM8935645","GSM8935887","GSM8935644","GSM8935886","GSM8935647","GSM8935889",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