{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294988/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294988"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part21]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294988","cross_references":{"GSM":["GSM8937070","GSM8937073","GSM8937074","GSM8937071","GSM8937072","GSM8937077","GSM8937078","GSM8937075","GSM8937076","GSM8937079","GSM8937080","GSM8937081","GSM8937084","GSM8937085","GSM8937082","GSM8937083","GSM8937088","GSM8937089","GSM8937086","GSM8937087","GSM8937290","GSM8937051","GSM8937293","GSM8937294","GSM8937052","GSM8937291","GSM8937050","GSM8937292","GSM8937297","GSM8937055","GSM8937056","GSM8937298","GSM8937053","GSM8937295","GSM8937296","GSM8937054","GSM8937059","GSM8937299","GSM8937057","GSM8937058","GSM8937062","GSM8937063","GSM8937060","GSM8937061","GSM8937066","GSM8937067","GSM8937064","GSM8937065","GSM8937068","GSM8937069","GSM8937039","GSM8937271","GSM8937030","GSM8937272","GSM8937270","GSM8937033","GSM8937275","GSM8937276","GSM8937034","GSM8937031","GSM8937273","GSM8937274","GSM8937032","GSM8937279","GSM8937037","GSM8937038","GSM8937277","GSM8937035","GSM8937036","GSM8937278","GSM8937282","GSM8937040","GSM8937283","GSM8937041","GSM8937280","GSM8937281","GSM8937286","GSM8937044","GSM8937045","GSM8937287","GSM8937042","GSM8937284","GSM8937285","GSM8937043","GSM8937048","GSM8937049","GSM8937288","GSM8937046","GSM8937047","GSM8937289","GSM8937019","GSM8937259","GSM8937017","GSM8937018","GSM8937491","GSM8937492","GSM8937250","GSM8937490","GSM8937011","GSM8937495","GSM8937253","GSM8937254","GSM8937012","GSM8937496","GSM8937251","GSM8937493","GSM8937010","GSM8937494","GSM8937252","GSM8937257","GSM8937015","GSM8937499","GSM8937016","GSM8937258","GSM8937497","GSM8937013","GSM8937255","GSM8937256","GSM8937498","GSM8937014","GSM8937028","GSM8937029","GSM8937260","GSM8937261","GSM8937022","GSM8937264","GSM8937265","GSM8937023","GSM8937262","GSM8937020","GSM8937263","GSM8937021","GSM8937268","GSM8937026","GSM8937027","GSM8937269","GSM8937266","GSM8937024","GSM8937025","GSM8937267","GSM8937239","GSM8937237","GSM8937479","GSM8937238","GSM8937470","GSM8937231","GSM8937473","GSM8937474","GSM8937232","GSM8937471","GSM8937472","GSM8937230","GSM8937477","GSM8937235","GSM8937236","GSM8937478","GSM8937233","GSM8937475","GSM8937234","GSM8937476","GSM8937008","GSM8937009","GSM8937248","GSM8937006","GSM8937007","GSM8937249","GSM8937480","GSM8937481","GSM8937242","GSM8937000","GSM8937484","GSM8937485","GSM8937243","GSM8937001","GSM8937482","GSM8937240","GSM8937483","GSM8937241","GSM8937488","GSM8937004","GSM8937246","GSM8937005","GSM8937489","GSM8937247","GSM8937002","GSM8937486","GSM8937244","GSM8937245","GSM8937487","GSM8937003","GSM8937217","GSM8937459","GSM8937218","GSM8937457","GSM8937215","GSM8937216","GSM8937458","GSM8937219","GSM8937451","GSM8937452","GSM8937210","GSM8937450","GSM8937213","GSM8937455","GSM8937214","GSM8937456","GSM8937211","GSM8937453","GSM8937454","GSM8937212","GSM8937228","GSM8937229","GSM8937468","GSM8937226","GSM8937469","GSM8937227","GSM8937462","GSM8937220","GSM8937463","GSM8937221","GSM8937460","GSM8937461","GSM8937466","GSM8937224","GSM8937225","GSM8937467","GSM8937222","GSM8937464","GSM8937465","GSM8937223","GSM8937437","GSM8937438","GSM8937435","GSM8936588","GSM8936589","GSM8937436","GSM8937439","GSM8936582","GSM8937430","GSM8936583","GSM8936580","GSM8936581","GSM8936586","GSM8937433","GSM8937434","GSM8936587","GSM8937431","GSM8936584","GSM8937432","GSM8936585","GSM8937448","GSM8937206","GSM8937449","GSM8937207","GSM8937446","GSM8936599","GSM8937204","GSM8937205","GSM8937447","GSM8937208","GSM8937209","GSM8936590","GSM8937440","GSM8936593","GSM8937441","GSM8936594","GSM8936591","GSM8936592","GSM8937202","GSM8937444","GSM8936597","GSM8937445","GSM8936598","GSM8937203","GSM8937442","GSM8936595","GSM8937200","GSM8937443","GSM8936596","GSM8937201","GSM8937415","GSM8936568","GSM8936569","GSM8937416","GSM8936566","GSM8937413","GSM8937414","GSM8936567","GSM8937419","GSM8937417","GSM8937418","GSM8936560","GSM8936561","GSM8937411","GSM8936564","GSM8937412","GSM8936565","GSM8936562","GSM8937410","GSM8936563","GSM8937426","GSM8936579","GSM8937427","GSM8937424","GSM8936577","GSM8937425","GSM8936578","GSM8937428","GSM8937429","GSM8936571","GSM8936572","GSM8936570","GSM8937422","GSM8936575","GSM8936576","GSM8937423","GSM8937420","GSM8936573","GSM8937421","GSM8936574","GSM8936788","GSM8936789","GSM8936786","GSM8936787","GSM8936780","GSM8936781","GSM8936784","GSM8936785","GSM8936782","GSM8936783","GSM8936799","GSM8936557","GSM8937404","GSM8937405","GSM8936558","GSM8937402","GSM8936555","GSM8936797","GSM8936798","GSM8937403","GSM8936556","GSM8937408","GSM8937409","GSM8937406","GSM8936559","GSM8937407","GSM8936791","GSM8936550","GSM8936792","GSM8936790","GSM8937400","GSM8936553","GSM8936795","GSM8936796","GSM8937401","GSM8936554","GSM8936793","GSM8936551","GSM8936552","GSM8936794","GSM8936766","GSM8936767","GSM8936764","GSM8936765","GSM8936768","GSM8936769","GSM8936762","GSM8936763","GSM8936760","GSM8936761","GSM8936777","GSM8936778","GSM8936775","GSM8936776","GSM8936779","GSM8936770","GSM8936773",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