{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294992/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294992"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part22]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294992","cross_references":{"GSM":["GSM8938162","GSM8938163","GSM8938160","GSM8938161","GSM8938166","GSM8938167","GSM8938164","GSM8938165","GSM8938168","GSM8938169","GSM8938170","GSM8938173","GSM8938174","GSM8938171","GSM8938172","GSM8938177","GSM8938178","GSM8938175","GSM8938176","GSM8938179","GSM8938140","GSM8938382","GSM8938383","GSM8938141","GSM8938380","GSM8938381","GSM8938386","GSM8938144","GSM8938387","GSM8938145","GSM8938384","GSM8938142","GSM8938143","GSM8938385","GSM8938148","GSM8938149","GSM8938146","GSM8938388","GSM8938389","GSM8938147","GSM8938390","GSM8938151","GSM8938393","GSM8938152","GSM8938394","GSM8938391","GSM8938392","GSM8938150","GSM8938155","GSM8938397","GSM8938398","GSM8938156","GSM8938395","GSM8938153","GSM8938154","GSM8938396","GSM8938159","GSM8938157","GSM8938399","GSM8938158","GSM8938128","GSM8938129","GSM8938360","GSM8938361","GSM8938364","GSM8938122","GSM8938123","GSM8938365","GSM8938120","GSM8938362","GSM8938363","GSM8938121","GSM8938126","GSM8938368","GSM8938369","GSM8938127","GSM8938366","GSM8938124","GSM8938367","GSM8938125","GSM8938139","GSM8938371","GSM8938372","GSM8938130","GSM8938370","GSM8938375","GSM8938133","GSM8938134","GSM8938376","GSM8938131","GSM8938373","GSM8938132","GSM8938374","GSM8938137","GSM8938379","GSM8938138","GSM8938135","GSM8938377","GSM8938378","GSM8938136","GSM8938108","GSM8938109","GSM8938106","GSM8938348","GSM8938349","GSM8938107","GSM8938580","GSM8938581","GSM8938100","GSM8938584","GSM8938342","GSM8938343","GSM8938101","GSM8938585","GSM8938340","GSM8938582","GSM8938341","GSM8938583","GSM8938346","GSM8938104","GSM8938588","GSM8938589","GSM8938347","GSM8938105","GSM8938344","GSM8938102","GSM8938586","GSM8938587","GSM8938103","GSM8938345","GSM8938119","GSM8938117","GSM8938359","GSM8938118","GSM8938591","GSM8938592","GSM8938350","GSM8938590","GSM8938111","GSM8938353","GSM8938112","GSM8938354","GSM8938593","GSM8938351","GSM8938352","GSM8938110","GSM8938115","GSM8938357","GSM8938358","GSM8938116","GSM8938355","GSM8938113","GSM8938114","GSM8938356","GSM8938328","GSM8938329","GSM8938326","GSM8938568","GSM8938569","GSM8938327","GSM8938320","GSM8938562","GSM8938321","GSM8938563","GSM8938560","GSM8938561","GSM8938566","GSM8938324","GSM8938567","GSM8938325","GSM8938564","GSM8938322","GSM8938323","GSM8938565","GSM8938339","GSM8938337","GSM8938579","GSM8938338","GSM8938570","GSM8938573","GSM8938331","GSM8938332","GSM8938574","GSM8938571","GSM8938572","GSM8938330","GSM8938335","GSM8938577","GSM8938578","GSM8938336","GSM8938575","GSM8938333","GSM8938576","GSM8938334","GSM8938306","GSM8938548","GSM8938549","GSM8938307","GSM8938546","GSM8937699","GSM8938304","GSM8938547","GSM8938305","GSM8938308","GSM8938309","GSM8937690","GSM8937693","GSM8938540","GSM8938541","GSM8937694","GSM8937691","GSM8937692","GSM8938544","GSM8937697","GSM8938302","GSM8938303","GSM8938545","GSM8937698","GSM8938300","GSM8938542","GSM8937695","GSM8937696","GSM8938301","GSM8938543","GSM8938317","GSM8938559","GSM8938318","GSM8938315","GSM8938557","GSM8938558","GSM8938316","GSM8938319","GSM8938551","GSM8938552","GSM8938310","GSM8938550","GSM8938555","GSM8938313","GSM8938556","GSM8938314","GSM8938553","GSM8938311","GSM8938312","GSM8938554","GSM8938526","GSM8937679","GSM8938527","GSM8938524","GSM8937677","GSM8938525","GSM8937678","GSM8938528","GSM8938529","GSM8937671","GSM8937672","GSM8937670","GSM8938522","GSM8937675","GSM8937676","GSM8938523","GSM8937673","GSM8938520","GSM8938521","GSM8937674","GSM8938537","GSM8938538","GSM8938535","GSM8937688","GSM8938536","GSM8937689","GSM8938539","GSM8937682","GSM8938530","GSM8937683","GSM8937680","GSM8937681","GSM8938533","GSM8937686","GSM8938534","GSM8937687","GSM8938531","GSM8937684","GSM8938532","GSM8937685","GSM8938504","GSM8937657","GSM8937899","GSM8938505","GSM8937658","GSM8937897","GSM8938502","GSM8937655","GSM8937656","GSM8938503","GSM8937898","GSM8938508","GSM8938509","GSM8938506","GSM8937659","GSM8938507","GSM8937891","GSM8937650","GSM8937892","GSM8937890","GSM8937653","GSM8937895","GSM8938500","GSM8938501","GSM8937654","GSM8937896","GSM8937651","GSM8937893","GSM8937894","GSM8937652","GSM8938515","GSM8937668","GSM8938516","GSM8937669","GSM8938513","GSM8937666","GSM8938514","GSM8937667","GSM8938519","GSM8938517","GSM8938518","GSM8937660","GSM8937661","GSM8938511","GSM8937664","GSM8937665","GSM8938512","GSM8937662","GSM8938510","GSM8937663","GSM8937877","GSM8937635","GSM8937636","GSM8937633","GSM8937875","GSM8937634","GSM8937876","GSM8937639","GSM8937879","GSM8937637","GSM8937638","GSM8937870","GSM8937631","GSM8937873","GSM8937874","GSM8937632","GSM8937871","GSM8937630","GSM8937872","GSM8937646","GSM8937889","GSM8937647","GSM8937644","GSM8937645","GSM8937887","GSM8937648","GSM8937649","GSM8937881","GSM8937642","GSM8937885","GSM8937643","GSM8937640","GSM8937883","GSM8937641","GSM8937613","GSM8937855","GSM8937614","GSM8937856","GSM8937611","GSM8937853","GSM8937854","GSM8937612","GSM8937859",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