{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294994/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294994"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part23]","description":"The central nervous system represents a uniquely immune-privileged environment, with inflammatory responses involving several resident CNS-specific cell types. While stereotyped cellular and transcriptional responses recur across varied diseases, relevant signaling pathways and regulatory networks are not fully understood. Here, we describe a screening platform based on high-throughput RNA-seq analysis and glial cell state gene set scores that enables multimodal investigation of inflammatory networks at scale. As proof-of-concept, we investigate genetically heterogeneous mice from a large-scale chemical mutagenesis screen to identify novel functionally relevant variants in six genes previously linked to human CNS disorders: Nrros, Ctsd, Smpd1, Idua, Nlrp1a, and Inpp5d . We leverage the rich and readily-interpretable data from our study to demarcate distinct inflammatory states arising from each mutation. In all, our work provides a methodology for discovering novel regulators of CNS neuroimmune homeostasis and provides a validated analysis framework for identifying discrete neuroinflammatory modules that are engaged divergently across disease contexts.","dates":{"publication":"2026/04/11"},"accession":"GSE294994","cross_references":{"GSM":["GSM8939019","GSM8939490","GSM8939010","GSM8939494","GSM8939252","GSM8939493","GSM8939251","GSM8939250","GSM8939492","GSM8939491","GSM8939256","GSM8939498","GSM8939014","GSM8939013","GSM8939497","GSM8939255","GSM8939496","GSM8939254","GSM8939012","GSM8939253","GSM8939011","GSM8939495","GSM8939018","GSM8939259","GSM8939017","GSM8939016","GSM8939258","GSM8939499","GSM8939015","GSM8939257","GSM8939021","GSM8939263","GSM8939262","GSM8939020","GSM8939261","GSM8939260","GSM8939267","GSM8939025","GSM8939024","GSM8939266","GSM8939265","GSM8939023","GSM8939264","GSM8939022","GSM8939029","GSM8939028","GSM8939027","GSM8939269","GSM8939268","GSM8939026","GSM8939239","GSM8939230","GSM8939472","GSM8939471","GSM8939470","GSM8939476","GSM8939234","GSM8939233","GSM8939475","GSM8939474","GSM8939232","GSM8939473","GSM8939231","GSM8939238","GSM8939479","GSM8939237","GSM8939236","GSM8939478","GSM8939477","GSM8939235","GSM8939009","GSM8939008","GSM8939483","GSM8939241","GSM8939482","GSM8939240","GSM8939481","GSM8939480","GSM8939245","GSM8939003","GSM8939487","GSM8939244","GSM8939002","GSM8939486","GSM8939001","GSM8939485","GSM8939243","GSM8939242","GSM8939000","GSM8939484","GSM8939007","GSM8939249","GSM8939248","GSM8939006","GSM8939247","GSM8939005","GSM8939489","GSM8939004","GSM8939488","GSM8939246","GSM8939219","GSM8939218","GSM8939459","GSM8939217","GSM8939450","GSM8939454","GSM8939212","GSM8939453","GSM8939211","GSM8939210","GSM8939452","GSM8939451","GSM8939216","GSM8939458","GSM8939457","GSM8939215","GSM8939456","GSM8939214","GSM8939213","GSM8939455","GSM8939229","GSM8939228","GSM8939461","GSM8939460","GSM8939465","GSM8939223","GSM8939222","GSM8939464","GSM8939463","GSM8939221","GSM8939462","GSM8939220","GSM8939227","GSM8939469","GSM8939468","GSM8939226","GSM8939225","GSM8939467","GSM8939224","GSM8939466","GSM8939439","GSM8939438","GSM8939437","GSM8939432","GSM8939431","GSM8939430","GSM8939436","GSM8939435","GSM8939434","GSM8939433","GSM8939209","GSM8939208","GSM8939207","GSM8939449","GSM8939448","GSM8939206","GSM8939201","GSM8939443","GSM8939442","GSM8939200","GSM8939441","GSM8939440","GSM8939205","GSM8938599","GSM8939447","GSM8939204","GSM8939446","GSM8939445","GSM8939203","GSM8939202","GSM8939444","GSM8939418","GSM8939417","GSM8939416","GSM8939415","GSM8939419","GSM8939410","GSM8939414","GSM8939413","GSM8939412","GSM8939411","GSM8939429","GSM8939428","GSM8939427","GSM8939426","GSM8939421","GSM8939420","GSM8939425","GSM8939424","GSM8939423","GSM8939422","GSM8938789","GSM8938788","GSM8938783","GSM8938782","GSM8938781","GSM8938780","GSM8938787","GSM8938786","GSM8938785","GSM8938784","GSM8939407","GSM8939406","GSM8939405","GSM8938799","GSM8939404","GSM8939409","GSM8939408","GSM8938790","GSM8938794","GSM8938793","GSM8938792","GSM8938791","GSM8938798","GSM8939403","GSM8939402","GSM8938797","GSM8938796","GSM8939401","GSM8938795","GSM8939400","GSM8938769","GSM8938768","GSM8938767","GSM8938766","GSM8938761","GSM8938760","GSM8938765","GSM8938764","GSM8938763","GSM8938762","GSM8938779","GSM8938778","GSM8938777","GSM8938772","GSM8938771","GSM8938770","GSM8938776","GSM8938775","GSM8938774","GSM8938773","GSM8938747","GSM8938989","GSM8938746","GSM8938988","GSM8938987","GSM8938745","GSM8938744","GSM8938986","GSM8938749","GSM8938748","GSM8938981","GSM8938980","GSM8938743","GSM8938985","GSM8938984","GSM8938742","GSM8938741","GSM8938983","GSM8938982","GSM8938740","GSM8938758","GSM8938999","GSM8938757","GSM8938998","GSM8938756","GSM8938755","GSM8938997","GSM8938759","GSM8938750","GSM8938992","GSM8938991","GSM8938990","GSM8938996","GSM8938754","GSM8938995","GSM8938753","GSM8938752","GSM8938994","GSM8938993","GSM8938751","GSM8938967","GSM8938725","GSM8938724","GSM8938966","GSM8938723","GSM8938965","GSM8938964","GSM8938722","GSM8938729","GSM8938728","GSM8938727","GSM8938969","GSM8938726","GSM8938968","GSM8938721","GSM8938963","GSM8938962","GSM8938720","GSM8938961","GSM8938960","GSM8938978","GSM8938736","GSM8938735","GSM8938977","GSM8938976","GSM8938734","GSM8938975","GSM8938733","GSM8938739","GSM8938738","GSM8938979","GSM8938737","GSM8938970","GSM8938732","GSM8938974","GSM8938973","GSM8938731","GSM8938972","GSM8938730","GSM8938971","GSM8938703","GSM8938945","GSM8938944","GSM8938702","GSM8938701","GSM8938943","GSM8938942","GSM8938700","GSM8938707","GSM8938949","GSM8938706","GSM8938948","GSM8938947","GSM8938705","GSM8938704","GSM8938946","GSM8938709","GSM8938708","GSM8938941","GSM8938940","GSM8938956","GSM8938714","GSM8938955","GSM8938713","GSM8938712","GSM8938954","GSM8938953","GSM8938711","GSM8938718","GSM8938959","GSM8938717","GSM8938958","GSM8938716","GSM8938715","GSM8938957","GSM8938719","GSM8938952","GSM8938710","GSM8938951","GSM8938950","GSM8938923","GSM8938922","GSM8938921","GSM8938920","GSM8938927","GSM8938926","GSM8938925","GSM8938924","GSM8938929","GSM8938928","GSM8938934","GSM8938933","GSM8938932","GSM8938931","GSM8938938","GSM8938937","GSM8938936","GSM8938935","GSM8938939","GSM8938930","GSM8938901","GSM8938900","GSM8938905","GSM8938904","GSM8938903","GSM8938902","GSM8938909","GSM8938908","GSM8938907","GSM8938906","GSM8938912","GSM8938911","GSM8938910","GSM8938916","GSM8938915","GSM8938914","GSM8938913","GSM8938919","GSM8938918","GSM8938917","GSM8939193","GSM8939192","GSM8939191","GSM8939190","GSM8939197","GSM8939196","GSM8939195","GSM8939194","GSM8939199","GSM8939198","GSM8939171","GSM8939170","GSM8939175","GSM8939174","GSM8939173","GSM8939172","GSM8939179","GSM8939178","GSM8939177","GSM8939176","GSM8939182","GSM8939181","GSM8939180","GSM8939186","GSM8939185","GSM8939184","GSM8939183","GSM8939189","GSM8939188","GSM8939187","GSM8939391","GSM8939390","GSM8939153","GSM8939395","GSM8939394","GSM8939152","GSM8939393","GSM8939151","GSM8939150","GSM8939392","GSM8939399","GSM8939157","GSM8939156","GSM8939398","GSM8939397","GSM8939155","GSM8939396","GSM8939154","GSM8939159","GSM8939158","GSM8939160","GSM8939164","GSM8939163","GSM8939162","GSM8939161","GSM8939168","GSM8939167","GSM8939166","GSM8939165","GSM8939169","GSM8939373","GSM8939131","GSM8939130","GSM8939372","GSM8939371","GSM8939370","GSM8939377","GSM8939135","GSM8939376","GSM8939134","GSM8939133","GSM8939375","GSM8939374","GSM8939132","GSM8939139","GSM8939138","GSM8939379","GSM8939137","GSM8939136","GSM8939378","GSM8939380","GSM8939142","GSM8939384","GSM8939141","GSM8939383","GSM8939382","GSM8939140","GSM8939381","GSM8939388","GSM8939146","GSM8939145","GSM8939387","GSM8939144","GSM8939386","GSM8939385","GSM8939143","GSM8939149","GSM8939148","GSM8939147","GSM8939389","GSM8939119","GSM8939118","GSM8939351","GSM8939593","GSM8939350","GSM8939592","GSM8939591","GSM8939590","GSM8939113","GSM8939597","GSM8939355","GSM8939596","GSM8939354","GSM8939112","GSM8939353","GSM8939111","GSM8939595","GSM8939110","GSM8939594","GSM8939352","GSM8939359","GSM8939117","GSM8939116","GSM8939358","GSM8939357","GSM8939115","GSM8939356","GSM8939114","GSM8939598","GSM8939129","GSM8939362","GSM8939120","GSM8939361","GSM8939360","GSM8939124","GSM8939366","GSM8939365","GSM8939123","GSM8939122","GSM8939364","GSM8939121","GSM8939363","GSM8939128","GSM8939127","GSM8939369","GSM8939368","GSM8939126","GSM8939367","GSM8939125","GSM8939339","GSM8939338","GSM8939571","GSM8939570","GSM8939333","GSM8939575","GSM8939574","GSM8939332","GSM8939331","GSM8939573","GSM8939330","GSM8939572","GSM8939579","GSM8939337","GSM8939336","GSM8939578","GSM8939577","GSM8939335","GSM8939576","GSM8939334","GSM8939109","GSM8939108","GSM8939107","GSM8939349","GSM8939582","GSM8939340","GSM8939581","GSM8939580","GSM8939102","GSM8939586","GSM8939344","GSM8939101","GSM8939585","GSM8939343","GSM8939342","GSM8939100","GSM8939584","GSM8939583","GSM8939341","GSM8939348","GSM8939106","GSM8939347","GSM8939105","GSM8939589","GSM8939104","GSM8939588","GSM8939346","GSM8939345","GSM8939103","GSM8939587","GSM8939319","GSM8939318","GSM8939559","GSM8939317","GSM8939316","GSM8939558","GSM8939311","GSM8939553","GSM8939310","GSM8939552","GSM8939551","GSM8939550","GSM8939557","GSM8939315","GSM8939556","GSM8939314","GSM8939313","GSM8939555","GSM8939554","GSM8939312","GSM8939329","GSM8939328","GSM8939327","GSM8939569","GSM8939560","GSM8939322","GSM8939564","GSM8939563","GSM8939321","GSM8939562","GSM8939320","GSM8939561","GSM8939568","GSM8939326","GSM8939325","GSM8939567","GSM8939566","GSM8939324","GSM8939565","GSM8939323","GSM8939539","GSM8939538","GSM8939537","GSM8939536","GSM8938689","GSM8938680","GSM8939531","GSM8938684","GSM8938683","GSM8939530","GSM8938682","GSM8938681","GSM8939535","GSM8938688","GSM8939534","GSM8938687","GSM8938686","GSM8939533","GSM8938685","GSM8939532","GSM8939308","GSM8939307","GSM8939549","GSM8939548","GSM8939306","GSM8939305","GSM8939547","GSM8939309","GSM8938691","GSM8938690","GSM8938695","GSM8939542","GSM8939300","GSM8938694","GSM8939541","GSM8939540","GSM8938693","GSM8938692","GSM8939546","GSM8938699","GSM8939304","GSM8939545","GSM8938698","GSM8939303","GSM8939302","GSM8938697","GSM8939544","GSM8939543","GSM8938696","GSM8939301","GSM8939517","GSM8939516","GSM8938669","GSM8938668","GSM8939515","GSM8939514","GSM8938667","GSM8939519","GSM8939518","GSM8938662","GSM8938661","GSM8938660","GSM8938666","GSM8939513","GSM8938665","GSM8939512","GSM8939511","GSM8938664","GSM8938663","GSM8939510","GSM8939528","GSM8939527","GSM8939526","GSM8938679","GSM8939525","GSM8938678","GSM8939529","GSM8939520","GSM8938673","GSM8938672","GSM8938671","GSM8938670","GSM8939524","GSM8938677","GSM8939523","GSM8938676","GSM8938675","GSM8939522","GSM8939521","GSM8938674","GSM8938648","GSM8938889","GSM8938647","GSM8938646","GSM8938888","GSM8938887","GSM8938645","GSM8938649","GSM8938640","GSM8938882","GSM8938881","GSM8938880","GSM8938644","GSM8938886","GSM8938643","GSM8938885","GSM8938884","GSM8938642","GSM8938641","GSM8938883","GSM8939506","GSM8938659","GSM8939505","GSM8938658","GSM8938899","GSM8939504","GSM8938657","GSM8938898","GSM8938656","GSM8939503","GSM8939509","GSM8939508","GSM8939507","GSM8938893","GSM8938651","GSM8938892","GSM8938650","GSM8938891","GSM8938890","GSM8939502","GSM8938655","GSM8938897","GSM8938896","GSM8939501","GSM8938654","GSM8938895","GSM8939500","GSM8938653","GSM8938652","GSM8938894","GSM8938626","GSM8938868","GSM8938867","GSM8938625","GSM8938624","GSM8938866","GSM8938623","GSM8938865","GSM8938629","GSM8938628","GSM8938869","GSM8938627","GSM8938860","GSM8938864","GSM8938622","GSM8938621","GSM8938863","GSM8938620","GSM8938862","GSM8938861","GSM8938879","GSM8938637","GSM8938878","GSM8938636","GSM8938635","GSM8938877","GSM8938876","GSM8938634","GSM8938639","GSM8938638","GSM8938871","GSM8938870","GSM8938875","GSM8938633","GSM8938632","GSM8938874","GSM8938873","GSM8938631","GSM8938872","GSM8938630","GSM8938604","GSM8938846","GSM8938603","GSM8938845","GSM8938844","GSM8938602","GSM8938601","GSM8938843","GSM8938608","GSM8938849","GSM8938607","GSM8938606","GSM8938848","GSM8938847","GSM8938605","GSM8938609","GSM8938600","GSM8938842","GSM8938841","GSM8938840","GSM8938615","GSM8938857","GSM8938856","GSM8938614","GSM8938855","GSM8938613","GSM8938612","GSM8938854","GSM8938619","GSM8938618","GSM8938859","GSM8938617","GSM8938858","GSM8938616","GSM8938853","GSM8938611","GSM8938852","GSM8938610","GSM8938851","GSM8938850","GSM8938824","GSM8938823","GSM8938822","GSM8938821","GSM8938828","GSM8938827","GSM8938826","GSM8938825","GSM8938829","GSM8938820","GSM8938835","GSM8938834","GSM8938833","GSM8938832","GSM8938839","GSM8938838","GSM8938837","GSM8938836","GSM8938831","GSM8938830","GSM8938802","GSM8938801","GSM8938800","GSM8938806","GSM8938805","GSM8938804","GSM8938803","GSM8938809","GSM8938808","GSM8938807","GSM8938813","GSM8938812","GSM8938811","GSM8938810","GSM8938817","GSM8938816","GSM8938815","GSM8938814","GSM8938819","GSM8938818","GSM8939094","GSM8939093","GSM8939092","GSM8939091","GSM8939098","GSM8939097","GSM8939096","GSM8939095","GSM8939099","GSM8939072","GSM8939071","GSM8939070","GSM8939076","GSM8939075","GSM8939074","GSM8939073","GSM8939079","GSM8939078","GSM8939077","GSM8939090","GSM8939083","GSM8939082","GSM8939081","GSM8939080","GSM8939087","GSM8939086","GSM8939085","GSM8939084","GSM8939089","GSM8939088","GSM8939050","GSM8939292","GSM8939291","GSM8939290","GSM8939296","GSM8939054","GSM8939053","GSM8939295","GSM8939294","GSM8939052","GSM8939293","GSM8939051","GSM8939058","GSM8939299","GSM8939057","GSM8939056","GSM8939298","GSM8939055","GSM8939297","GSM8939059","GSM8939061","GSM8939060","GSM8939065","GSM8939064","GSM8939063","GSM8939062","GSM8939069","GSM8939068","GSM8939067","GSM8939066","GSM8939270","GSM8939274","GSM8939032","GSM8939273","GSM8939031","GSM8939030","GSM8939272","GSM8939271","GSM8939036","GSM8939278","GSM8939035","GSM8939277","GSM8939276","GSM8939034","GSM8939033","GSM8939275","GSM8939039","GSM8939038","GSM8939279","GSM8939037","GSM8939281","GSM8939280","GSM8939285","GSM8939043","GSM8939284","GSM8939042","GSM8939041","GSM8939283","GSM8939282","GSM8939040","GSM8939047","GSM8939289","GSM8939288","GSM8939046","GSM8939287","GSM8939045","GSM8939044","GSM8939286","GSM8939049","GSM8939048"],"GPL":["24247"],"GSE":["294994"],"taxon":["Mus musculus"]}}