GEOTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295159GEOGSEfalseTranscriptome profiling of SKHEP1 cells and differentiated SKHEP1 cells induced by knockdown of SETDB1 using RNA-sequencingThe core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. Therefore, cancer cells can supposedly be induced to differentiate along different lineages. SKHEP1 is a human hepatocellular carcinoma cell line. SETDB1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of SETDB1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. SETDB1 is upregulated in cancer cells and promotes cancers. We found that knockdown of SETDB1 in SKHEP1 cells led to a neuronal-like differentiation phenotype.2026/06/01GSE295159GSM8942796GSM894279524676295159Homo sapiens