{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295204/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295204"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of iPSC-derived microglia(iMGL) reveals FGL2-mediated Aβ uptake impairment and argatroban rescue associated with rs73375428 genotype.","description":"To elucidate how the rs73375428 major allele impairs Aβ uptake and how argatroban rescues this impairment independently of thrombin inhibition, we performed RNA sequencing and bioinformatic analyses in iPSC-derived microglia(iMGL). These datasets provide insight into transcriptomic changes associated with FGL2 modulation and Alzheimer’s disease risk.","dates":{"publication":"2026/04/21"},"accession":"GSE295204","cross_references":{"GSM":["GSM8943560","GSM8943559","GSM8943557","GSM8943558","GSM8943555","GSM8943556","GSM8943553","GSM8943554","GSM8943552"],"GPL":["24676"],"GSE":["295204"],"taxon":["Homo sapiens"]}}