GEOOtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295237GEOGSEfalseExcitatory neurons and astrocytes-specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single-cell spatial transcriptomics [Spatial transcriptomic]Focal cortical dysplasia (FCD) is a common neurodevelopmental disorder characterized by malformations of cortical development and is a leading cause of drug-resistant epilepsy. In this study, we employed single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics sequencing (ST-seq) to investigate the molecular pathological features of FCD type I (FCDI) brain tissue from both cell type-specific and spatial heterogeneity perspectives. This integrated analysis provides novel theoretical insights into the pathogenesis of FCDI associated epilepsy.2026/04/21GSE295237GSM8944111GSM8944110GSM8944109GSM894410824676295237Homo sapiens[42068085]